Skin Care Products for Healthy and Diseased Skin

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Biopharmaceutics".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 1687

Special Issue Editor


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Guest Editor
Department of Pharmacy, Singidunum University, 11000 Belgrade, Serbia
Interests: skin delivery; dermal delivery; transdermal delivery; nanocarriers; liposomes; penetration enhancer
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Special Issue Information

Dear Colleagues,

The skin represents the largest organ in humans, and it covers the whole body. It is the body's first line of defense against undesired influences from the environment caused by exogenous substances. Thus, maintaining skin health is of crucial importance and necessitates a multifaceted approach.

Healthy and diseased skin require distinct yet essential skincare approaches to maintain their wellbeing and address specific concerns. Therefore, skin care products for healthy and diseased skin overlap somewhere, but they also differ because they address different needs and concerns.

In the case of healthy skin, skin care products are used for the delivery of actives to the skin with the aim to maintain the skin's barrier function, minimizing the disruption of the stratum corneum and the acid mantle. Furthermore, skin care products should be used to provide protection against harmful UV rays, preventing premature aging and reducing the risk of skin cancer.

In contrast to healthy skin, diseased skin (e.g., Eczema, Psoriasis, Acne, etc.) demands a rigorous clinical approach, i.e., the use of specialized skin care products besides prescription medications based on corticosteroids, retinoids, antibiotics, etc. Even systemic immunosuppressants could be warranted in severe cases.

Besides conventional products, innovative skincare products are continually emerging to respond to the diverse needs of both healthy and diseased skin. Various new skin-friendly emulsifiers (e.g., natural emulsifiers) and new actives (e.g., different plant extracts, etc.) for skin care have emerged in recent years. Emulsifier-free creams, such as derma membrane structure creams, with a physical structure similar to the skin barriers, are becoming popular as vehicles for modern skincare preparations. Pioneering research into the skin's microbiome underscores the significance of symbiotic microorganisms in dermatological health and disease; thus, microbiome-balancing products containing prebiotics, probiotics, and postbiotics are used to support a healthy skin ecosystem. Furthermore, DNA repair serums containing enzymes and peptides designed to repair DNA damage in the skin, caused by UV exposure and ageing, have been developed. In addition, skincare products designed to protect against blue light damage have also emerged. A hotspot in recent years has been skin care products with nanoparticle-based carriers for pharmaceutical and cosmetic active ingredients, which enhance skin delivery and the efficacy of drugs while minimizing their side effects.

Thus, with this Special Issue, we aim to highlight current progress in the use of conventional skin care products, as well as to represent novel approaches based on multifunctional modern skin care products.

Dr. Nina Dragićević
Guest Editor

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Keywords

  • skin care products
  • skin delivery
  • healthy skin
  • diseased skin
  • nanoparticle-based products
  • natural emulsifiers

Published Papers (1 paper)

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54 pages, 3711 KiB  
Review
Liposomes and Other Nanocarriers for the Treatment of Acne Vulgaris: Improved Therapeutic Efficacy and Skin Tolerability
by Nina Dragicevic and Howard I. Maibach
Pharmaceutics 2024, 16(3), 309; https://doi.org/10.3390/pharmaceutics16030309 - 22 Feb 2024
Viewed by 1431
Abstract
Acne vulgaris is a common dermatologic disorder that affects approximately 85% of teenagers, which significantly impacts the quality of life in adolescents. It is a chronic disease of the sebaceous follicles that is multifactorial in etiology. Topical treatment is the first choice for [...] Read more.
Acne vulgaris is a common dermatologic disorder that affects approximately 85% of teenagers, which significantly impacts the quality of life in adolescents. It is a chronic disease of the sebaceous follicles that is multifactorial in etiology. Topical treatment is the first choice for mild and moderate acne, while systemic therapy is reserved for severe and certain moderate cases. Topical treatments include retinoids (e.g., tretinoin and adapalene), antibiotics (e.g., clindamycine), and other agents (e.g., benzoyl peroxide and azelaic acid), often applied in combination. The mechanisms of action include antimicrobial, anti-inflammatory, and keratolytic activities, as well as sebum secretion reduction, and the normalization of follicular keratinization. However, these topical agents commonly induce side effects, such as dryness, burning, stinging, peeling, redness, erythema, and photosensitivity. Therefore, there is a need to reduce the side effects of anti-acne drugs, while maintaining or enhancing their therapeutic effectiveness. This article aims to comprehensively outline nanotechnology strategies, particularly the use of phospholipid-based nanocarriers like liposomes and related vesicles, to enhance therapeutic efficacy, skin tolerability, and patient compliance in the treatment of acne vulgaris. In addition, novel active ingredients encapsulated in vesicles beyond those recommended in official guidelines are discussed. Full article
(This article belongs to the Special Issue Skin Care Products for Healthy and Diseased Skin)
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