Biomedical Applications: Advances in Bioengineering and Drug Delivery

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 2521

Special Issue Editors


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Guest Editor
Escuela de Química y Farmacia, Facultad de Medicina, Universidad Andrés Bello, Santiago 8320000, Chile
Interests: intracellular nanoparticle trafficking; biological properties of natural and synthetic compounds; immunomodulation by biomaterials

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Guest Editor
Departamento de Química y Medio Ambiente, Universidad Técnica Federico Santa María, Valparaíso 2390123, Chile
Interests: nanoformulations; nerve tissue engineering; biomaterials; organ on a chip

Special Issue Information

Dear Colleagues,

In recent years, significant progress has been made developing bioengineering and intelligent drug delivery systems. In the area of bioengineering, there have been outstanding advances in biological therapy with proteins and antibodies, the development of new materials for tissue engineering, and the generation of biosensing systems. In parallel, as well as advances in bioengineering, drug delivery, and delivery systems have been successfully researched and developed with the idea of improving efficiency and, thus, reducing adverse drug effects.

These areas of development include various scientific aspects that must be addressed to understand the processes involved and the development of efficient systems. In this context, the study of physical and chemical interactions between the components of biological systems and the relationships between biochemical mechanisms and the physiological implications of the processes studied have significantly impacted the success of new proposals.

This Special Issue brings together new results of research related to the different aspects of bioengineering development, focusing on the investigation of therapeutic alternatives in addition to allowing the incorporation of reviews and short communications that offer readers a broad vision of the capabilities these developing technologies have.

Dr. María Carolina Otero
Dr. Yusser Olguín
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomedicine
  • tissue engineering
  • biomaterials
  • drug carrier
  • biological therapy

Published Papers (2 papers)

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15 pages, 5825 KiB  
Article
Effect of Electrical Stimulation on PC12 Cells Cultured in Different Hydrogels: Basis for the Development of Biomaterials in Peripheral Nerve Tissue Engineering
by Yusser Olguín, Mónica Selva, Diego Benavente, Nicole Orellana, Ivan Montenegro, Alejandro Madrid, Diego Jaramillo-Pinto, María Carolina Otero, Tomas P. Corrales and Cristian A. Acevedo
Pharmaceutics 2023, 15(12), 2760; https://doi.org/10.3390/pharmaceutics15122760 - 12 Dec 2023
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Abstract
Extensive damage to peripheral nerves is a health problem with few therapeutic alternatives. In this context, the development of tissue engineering seeks to obtain materials that can help recreate environments conducive to cellular development and functional repair of peripheral nerves. Different hydrogels have [...] Read more.
Extensive damage to peripheral nerves is a health problem with few therapeutic alternatives. In this context, the development of tissue engineering seeks to obtain materials that can help recreate environments conducive to cellular development and functional repair of peripheral nerves. Different hydrogels have been studied and presented as alternatives for future treatments to emulate the morphological characteristics of nerves. Along with this, other research proposes the need to incorporate electrical stimuli into treatments as agents that promote cell growth and differentiation; however, no precedent correlates the simultaneous effects of the types of hydrogel and electrical stimuli. This research evaluates the neural differentiation of PC12 cells, relating the effect of collagen, alginate, GelMA, and PEGDA hydrogels with electrical stimulation modulated in four different ways. Our results show significant correlations for different cultivation conditions. Electrical stimuli significantly increase neural differentiation for specific experimental conditions dependent on electrical frequency, not voltage. These backgrounds allow new material treatment schemes to be formulated through electrical stimulation in peripheral nerve tissue engineering. Full article
(This article belongs to the Special Issue Biomedical Applications: Advances in Bioengineering and Drug Delivery)
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20 pages, 1059 KiB  
Systematic Review
Biological Properties and Medical Applications of Carbonate Apatite: A Systematic Review
by Ralitsa Yotsova and Stefan Peev
Pharmaceutics 2024, 16(2), 291; https://doi.org/10.3390/pharmaceutics16020291 - 18 Feb 2024
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Abstract
Bone defects represent an everyday challenge for clinicians who work in the fields of orthopedic surgery, maxillofacial and oral surgery, otorhinolaryngology, and dental implantology. Various bone substitutes have been developed and utilized, according to the needs of bone reconstructive surgery. Carbonate apatite has [...] Read more.
Bone defects represent an everyday challenge for clinicians who work in the fields of orthopedic surgery, maxillofacial and oral surgery, otorhinolaryngology, and dental implantology. Various bone substitutes have been developed and utilized, according to the needs of bone reconstructive surgery. Carbonate apatite has gained popularity in recent years, due to its excellent tissue behavior and osteoconductive potential. This systematic review aims to evaluate the role of carbonate apatite in bone reconstructive surgery and tissue engineering, analyze its advantages and limitations, and suggest further directions for research and development. The Web of Science, PubMed, and Scopus electronic databases were searched for relevant review articles, published from January 2014 to 21 July 2023. The study was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Eighteen studies were included in the present review. The biological properties and medical applications of carbonate apatite (CO3Ap) are discussed and evaluated. The majority of articles demonstrated that CO3Ap has excellent biocompatibility, resorbability, and osteoconductivity. Furthermore, it resembles bone tissue and causes minimal immunological reactions. Therefore, it may be successfully utilized in various medical applications, such as bone substitution, scaffolding, implant coating, drug delivery, and tissue engineering. Full article
(This article belongs to the Special Issue Biomedical Applications: Advances in Bioengineering and Drug Delivery)
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