Topical Drug Carriers: Recent Advances and Future Challenges

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: 20 September 2024 | Viewed by 1013

Special Issue Editors


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Guest Editor
Department of Pharmaceutical Technology, Medical University of Białystok, Mickiewicza 2c, 15-222 Białystok, Poland
Interests: lipid carriers; low solubility; pharmaceutical technology; nanocarriers; topical drug delivery; formulation and characterization of dosage forms; drug release; skin permeation
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Pharmaceutical Technology, Medical University of Białystok, Mickiewicza 2c, 15-222 Białystok, Poland
Interests: lipid carriers; pharmaceutical technology; drug formulation; characterization of dosage forms; solubilization techniques; polymers; antimicrobial activity; skin penetration; topical drug delivery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Topical drug carriers represent an important form of drug delivery system, and their use in therapy as an alternative to oral administration is becoming more widespread. The goal in designing these formulations is to obtain systems with optimized drug loading and release properties, which are able to ensure adequate penetration of the active substance. The therapeutic efficacy of topical formulations depends on both the physicochemical properties of the active substance and the type of carrier. It is well known that vehicles used in topical dosage forms may greatly affect the rate and extent of drug permeation. Recent advances in topical and transdermal drug delivery systems have enabled targeted delivery of therapeutics to the site of action by enhancing drug permeation across the stratum corneum and increased bioavailability. Although latest innovations in nanotechnology have enhanced the ability of molecules to pass through the skin by improving the pharmacokinetics of drugs, an appropriate vehicle remains to be developed to ensure drug delivery using noninvasive techniques.

We welcome the submission of articles on the latest aspects of topical and transdermal drug delivery, particularly those focusing on improving drug efficacy and safety.

Dr. Anna Czajkowska-Kośnik
Dr. Magdalena Wróblewska
Guest Editors

Manuscript Submission Information

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Keywords

  • topical and transdermal delivery
  • nanocarriers
  • new technologies
  • drug permeation
  • skin absorption
  • therapeutic agent
  • innovative delivery systems
  • mucoadhesion
  • dosage form development
  • physicochemical properties

Published Papers (1 paper)

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Research

17 pages, 6150 KiB  
Article
Foams Set a New Pace for the Release of Diclofenac Sodium
by Fanni Falusi, Szilvia Berkó, Mária Budai-Szűcs, Zoltán Veréb and Anita Kovács
Pharmaceutics 2024, 16(2), 287; https://doi.org/10.3390/pharmaceutics16020287 - 18 Feb 2024
Viewed by 771
Abstract
Medicated foams have emerged as promising alternatives to traditional carrier systems in pharmaceutical research. Their rapid and convenient application allows for effective treatment of extensive or hirsute areas, as well as sensitive or inflamed skin surfaces. Foams possess excellent spreading capabilities on the [...] Read more.
Medicated foams have emerged as promising alternatives to traditional carrier systems in pharmaceutical research. Their rapid and convenient application allows for effective treatment of extensive or hirsute areas, as well as sensitive or inflamed skin surfaces. Foams possess excellent spreading capabilities on the skin, ensuring immediate drug absorption without the need for intense rubbing. Our research focuses on the comparison of physicochemical and biopharmaceutical properties of three drug delivery systems: foam, the foam bulk liquid, and a conventional hydrogel. During the development of the composition, widely used diclofenac sodium was employed. The safety of the formulae was confirmed through an in vitro cytotoxicity assay. Subsequently, the closed Franz diffusion cell was used to determine drug release and permeation in vitro. Ex vivo Raman spectroscopy was employed to investigate the presence of diclofenac sodium in various skin layers. The obtained results of the foam were compared to the bulk liquid and to a conventional hydrogel. In terms of drug release, the foam showed a rapid release, with 80% of diclofenac released within 30 min. In summary, the investigated foam holds promising potential as an alternative to traditional dermal carrier systems, offering faster drug release and permeation. Full article
(This article belongs to the Special Issue Topical Drug Carriers: Recent Advances and Future Challenges)
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