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Pharmaceutics
Special Issues
Polymer-Based Delivery System
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Polymer-Based Delivery System

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: 20 July 2024 | Viewed by 5927

Special Issue Editors

Prof. Dr. Jianqing Gao

E-Mail Website
Guest Editor
College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
Interests: targeting drug delivery; stem cells; wound healing; transdermal permeation; tissue regeneration; nano-size preparations; biomaterials
Prof. Dr. Jing Zhang

E-Mail Website
Guest Editor
Key Laboratory of Modern Preparation of Chinese Medicine, Ministry of Education, Jiangxi University of Chinese Medicine, Nanchang 330004, China
Interests: nanotechnology; ocular drug delivery; anti-tumor therapy; targeted drug delivery

Special Issue Information

Dear Colleagues,

Polymer-based delivery systems have shown considerable promise due to their physicochemical properties, composition, and versatility. The systems are suitable for chemical drugs, gene/peptides delivery and phytomedicine combination. Additionally, polymer-based delivery systems enhance bioactive compounds' stability and provide controlled release at the site of action, as well as acceptable biocompatibility. Bioresponsive polymeric carriers, as a new branch of carriers, are designed to release drugs on-demand based on specific scenarios. The strategy of application of polymers in drug delivery systems could reduce systemic toxicity and decrease drug resistance.

This Special Issue aims to collect a plethora of papers that cover the use of polymers in the pharmaceutical industry for theragnostic applications.

In this Special Issue, original research articles and reviews that highlight recent advances and the state of the art in the field of polymers are welcome. Research areas may include (but not limited to) the following: polymer therapeutics, diagnostic tolls, targeting delivery, drug combination, bioresponsive carriers, controlled release, stability and bioavailability, and stimuli-responsive materials.

We look forward to receiving your contributions.

Prof. Dr. Jianqing Gao
Prof. Dr. Jing Zhang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • polymer therapeutics
  • diagnostic tolls
  • targeting delivery
  • drug combination
  • bioresponsive carriers
  • controlled release
  • stability and bioavailability
  • stimuli-responsive materials

Published Papers (4 papers)

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Research

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18 pages, 4995 KiB  
Article
Curcumin-Loaded RH60/F127 Mixed Micelles: Characterization, Biopharmaceutical Characters and Anti-Inflammatory Modulation of Airway Inflammation
by Xinli Wang, Yanyan Wang, Tao Tang, Guowei Zhao, Wei Dong, Qiuxiang Li and Xinli Liang
Pharmaceutics 2023, 15(12), 2710; https://doi.org/10.3390/pharmaceutics15122710 - 30 Nov 2023
Cited by 1 | Viewed by 724
Abstract
Curcumin’s ability to impact chronic inflammatory conditions, such as metabolic syndrome and arthritis, has been widely researched; however, its poor bioavailability limits its clinical application. The present study is focused on the development of curcumin-loaded polymeric nanomicelles as a drug delivery system with [...] Read more.
Curcumin’s ability to impact chronic inflammatory conditions, such as metabolic syndrome and arthritis, has been widely researched; however, its poor bioavailability limits its clinical application. The present study is focused on the development of curcumin-loaded polymeric nanomicelles as a drug delivery system with anti-inflammatory effects. Curcumin was loaded in PEG-60 hydrogenated castor oil and puronic F127 mixed nanomicelles (Cur-RH60/F127-MMs). Cur-RH60/F127-MMs was prepared using the thin film dispersion method. The morphology and releasing characteristics of nanomicelles were evaluated. The uptake and permeability of Cur-RH60/F127-MMs were investigated using RAW264.7 and Caco-2 cells, and their bioavailability and in vivo/vitro anti-inflammatory activity were also evaluated. The results showed that Cur-RH60/F127-MMs have regular sphericity, possess an average diameter smaller than 20 nm, and high encapsulation efficiency for curcumin (89.43%). Cur-RH60/F127-MMs significantly increased the cumulative release of curcumin in vitro and uptake by cells (p < 0.01). The oral bioavailability of Cur-RH60/F127-MMs was much higher than that of curcumin-active pharmaceutical ingredients (Cur-API) (about 9.24-fold). The treatment of cell lines with Cur-RH60/F127-MMs exerted a significantly stronger anti-inflammatory effect compared to Cur-API. In addition, Cur-RH60/F127-MMs significantly reduced OVA-induced airway hyperresponsiveness and inflammation in an in vivo experimental asthma model. In conclusion, this study reveals the possibility of formulating a new drug delivery system for curcumin, in particular nanosized micellar aqueous dispersion, which could be considered a perspective platform for the application of curcumin in inflammatory diseases of the airways. Full article
(This article belongs to the Special Issue Polymer-Based Delivery System)
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Review

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23 pages, 6399 KiB  
Review
Smart Responsive and Controlled-Release Hydrogels for Chronic Wound Treatment
by Xintao Jia, Zixuan Dou, Ying Zhang, Fanqin Li, Bin Xing, Zheming Hu, Xin Li, Zhongyan Liu, Wenzhuo Yang and Zhidong Liu
Pharmaceutics 2023, 15(12), 2735; https://doi.org/10.3390/pharmaceutics15122735 - 06 Dec 2023
Cited by 1 | Viewed by 1217
Abstract
Chronic wounds are a major health challenge that require new treatment strategies. Hydrogels are promising drug delivery systems for chronic wound healing because of their biocompatibility, hydration, and flexibility. However, conventional hydrogels cannot adapt to the dynamic and complex wound environment, which involves [...] Read more.
Chronic wounds are a major health challenge that require new treatment strategies. Hydrogels are promising drug delivery systems for chronic wound healing because of their biocompatibility, hydration, and flexibility. However, conventional hydrogels cannot adapt to the dynamic and complex wound environment, which involves low pH, high levels of reactive oxygen species, and specific enzyme expression. Therefore, smart responsive hydrogels that can sense and respond to these stimuli are needed. Crucially, smart responsive hydrogels can modulate drug release and eliminate pathological factors by changing their properties or structures in response to internal or external stimuli, such as pH, enzymes, light, and electricity. These stimuli can also be used to trigger antibacterial responses, angiogenesis, and cell proliferation to enhance wound healing. In this review, we introduce the synthesis and principles of smart responsive hydrogels, describe their design and applications for chronic wound healing, and discuss their future development directions. We hope that this review will inspire the development of smart responsive hydrogels for chronic wound healing. Full article
(This article belongs to the Special Issue Polymer-Based Delivery System)
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20 pages, 1774 KiB  
Review
Hyaluronic Acid Nanogels: A Promising Platform for Therapeutic and Theranostic Applications
by Su Sundee Myint, Chavee Laomeephol, Sirikool Thamnium, Supakarn Chamni and Jittima Amie Luckanagul
Pharmaceutics 2023, 15(12), 2671; https://doi.org/10.3390/pharmaceutics15122671 - 25 Nov 2023
Viewed by 1916
Abstract
Hyaluronic acid (HA) nanogels are a versatile class of nanomaterials with specific properties, such as biocompatibility, hygroscopicity, and biodegradability. HA nanogels exhibit excellent colloidal stability and high encapsulation capacity, making them promising tools for a wide range of biomedical applications. HA nanogels can [...] Read more.
Hyaluronic acid (HA) nanogels are a versatile class of nanomaterials with specific properties, such as biocompatibility, hygroscopicity, and biodegradability. HA nanogels exhibit excellent colloidal stability and high encapsulation capacity, making them promising tools for a wide range of biomedical applications. HA nanogels can be fabricated using various methods, including polyelectrolyte complexation, self-assembly, and chemical crosslinking. The fabrication parameters can be tailored to control the physicochemical properties of HA nanogels, such as size, shape, surface charge, and porosity, enabling the rational design of HA nanogels for specific applications. Stimulus-responsive nanogels are a type of HA nanogels that can respond to external stimuli, such as pH, temperature, enzyme, and redox potential. This property allows the controlled release of encapsulated therapeutic agents in response to specific physiological conditions. HA nanogels can be engineered to encapsulate a variety of therapeutic agents, such as conventional drugs, genes, and proteins. They can then be delivered to target tissues with high efficiency. HA nanogels are still under development, but they have the potential to become powerful tools for a wide range of theranostic or solely therapeutic applications, including anticancer therapy, gene therapy, drug delivery, and bioimaging. Full article
(This article belongs to the Special Issue Polymer-Based Delivery System)
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85 pages, 8256 KiB  
Review
Polypeptide-Based Systems: From Synthesis to Application in Drug Delivery
by Mariia Stepanova, Alexey Nikiforov, Tatiana Tennikova and Evgenia Korzhikova-Vlakh
Pharmaceutics 2023, 15(11), 2641; https://doi.org/10.3390/pharmaceutics15112641 - 20 Nov 2023
Cited by 2 | Viewed by 1612
Abstract
Synthetic polypeptides are biocompatible and biodegradable macromolecules whose composition and architecture can vary over a wide range. Their unique ability to form secondary structures, as well as different pathways of modification and biofunctionalization due to the diversity of amino acids, provide variation in [...] Read more.
Synthetic polypeptides are biocompatible and biodegradable macromolecules whose composition and architecture can vary over a wide range. Their unique ability to form secondary structures, as well as different pathways of modification and biofunctionalization due to the diversity of amino acids, provide variation in the physicochemical and biological properties of polypeptide-containing materials. In this review article, we summarize the advances in the synthesis of polypeptides and their copolymers and the application of these systems for drug delivery in the form of (nano)particles or hydrogels. The issues, such as the diversity of polypeptide-containing (nano)particle types, the methods for their preparation and drug loading, as well as the influence of physicochemical characteristics on stability, degradability, cellular uptake, cytotoxicity, hemolysis, and immunogenicity of polypeptide-containing nanoparticles and their drug formulations, are comprehensively discussed. Finally, recent advances in the development of certain drug nanoformulations for peptides, proteins, gene delivery, cancer therapy, and antimicrobial and anti-inflammatory systems are summarized. Full article
(This article belongs to the Special Issue Polymer-Based Delivery System)
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