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Pharmaceutics
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3D Printing Technology Applied to the Preparation of Pediatric Orodispersible...
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3D Printing Technology Applied to the Preparation of Pediatric Orodispersible Dosage Forms

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Pharmaceutical Technology, Manufacturing and Devices".

Deadline for manuscript submissions: 20 June 2024 | Viewed by 1249

Special Issue Editors

Dr. Ana Santoveña-Estévez

E-Mail Website
Guest Editor
Departamento de Ingeniería Química y Tecnología Farmacéutica, Facultad de Farmacia, Universidad de La Laguna, 38200 La Laguna, Tenerife, Spain
Interests: pharmacy and pharmaceutical technology; pediatrics formulation; pharmaceutical compounding; micro-extrusion 3D technology; quality control; stability; chromatography; rheology
Special Issues, Collections and Topics in MDPI journals
Dr. Javier Suárez González

E-Mail Website
Guest Editor
Departamento de Ingeniería Química y Tecnología Farmacéutica, Facultad de Farmacia, Universidad de La Laguna, 38200 La Laguna, Tenerife, Spain
Interests: pharmacy and pharmaceutical technology; pediatrics formulation; pharmaceutical compounding; micro-extrusion 3D technology; quality control; stability; chromatography; mass spectroscopy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue serves to highlight and capture the latest research on the 3D printing technology applied to the preparation of pediatric orodispersible dosage forms, which is focused on meeting the need for personalized or industrial medicines to treat this vulnerable population.

We invite articles on all 3D technologies that can have an important role in the elaboration of orodispersable formulations, taking into account the fact that the quality of the final product must be guaranteed. It is for this reason that this topic must be supported by quality control strategies, such as process analytical technologies or multivariate statistical process control.

Submissions of original research articles and reviews in this rapidly expanding field of research are welcome.

Dr. Ana Santoveña-Estévez
Dr. Javier Suárez González
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pediatrics
  • quality control
  • orodispersible dosage form
  • 3D printing technology
  • process analytical technology

Published Papers (1 paper)

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Research

18 pages, 3548 KiB  
Article
Revolutionizing Three-Dimensional Printing: Enhancing Quality Assurance and Point-of-Care Integration through Instrumentation
by Javier Suárez-González, Eduardo Díaz-Torres, Cecilia N. Monzón-Rodríguez, Ana Santoveña-Estévez and José B. Fariña
Pharmaceutics 2024, 16(3), 408; https://doi.org/10.3390/pharmaceutics16030408 - 16 Mar 2024
Viewed by 869
Abstract
Three-dimensional printing in the field of additive manufacturing shows potential for customized medicines and solving gaps in paediatric formulations. Despite successful clinical trials, 3D printing use in pharmaceutical point-of-care is limited by regulatory loopholes and a lack of Pharmacopoeia guidelines to ensure quality. [...] Read more.
Three-dimensional printing in the field of additive manufacturing shows potential for customized medicines and solving gaps in paediatric formulations. Despite successful clinical trials, 3D printing use in pharmaceutical point-of-care is limited by regulatory loopholes and a lack of Pharmacopoeia guidelines to ensure quality. Semi-solid extrusion is a 3D printing technology that stands out for its versatility, but understanding the fluid dynamics of the semi-solid mass is critical. The aim of this research is to look into the advantages of instrumenting a 3D printer with a semi-solid extrusion motor-driven printhead, which is able to record the printing pressure over time, for in situ characterization of the semi-solid mass and quality evaluation of dosage forms. Four formulations using hydrochlorothiazide as the active pharmaceutical ingredient and several excipients were used. Their flow properties were studied at different printing speeds and temperatures using traditional techniques (rheometer and Texture Analyzer) and the proposed semi-solid extrusion motor-driven printhead incorporated into a printing platform. In addition, the influence of printing speed in the printing process was also evaluated by the study of printing pressure and printlet quality. The results demonstrated the similarities between the use of a Texture Analyzer and the semi-solid extrusion motor-driven. However, the latter enables temperature selection and printing speed in accordance with the printing process which are critical printing parameters. In addition, due to the incorporation of a sensor, it was possible to conclude, for the first time, that there is a link between changes in essential printing parameters like printing speed or formulations and variations in printing pressure and printlet quality attributes such as the energy require to obtain a single dosage unit, weight or diameter. This breakthrough holds a lot of potential for assuring the quality of 3D printing dosage forms and paving the way for their future incorporation into point-of-care settings. Full article
(This article belongs to the Special Issue 3D Printing Technology Applied to the Preparation of Pediatric Orodispersible Dosage Forms)
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