Special Issue "Extracellular Vesicles for Early Cancer Diagnosis and Therapy"

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Biologics and Biosimilars".

Deadline for manuscript submissions: 30 November 2023 | Viewed by 858

Special Issue Editors

Department of Pharmaceutical Sciences and Health Outcomes, The Ben and Maytee Fisch College of Pharmacy, University of Texas at Tyler, Tyler, TX 75799, USA
Interests: drug delivery; theranostics; cancer nanomedicine; imaging; cancer therapy; extracellular vesicles; exosomes
Special Issues, Collections and Topics in MDPI journals
Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS, USA
Interests: extracellular vesicles; biomaterials; drug delivery; imaging; cancer

Special Issue Information

Dear Colleagues,

Recent progress in the field of extracellular vesicles (EVs) has highlighted the importance of EVs as a biomarker in various physiological and pathological conditions including cancer.  The role of EVs in early events of malignancy leading to cancer progression and metastasis has been demonstrated in various cancer types, establishing a rationale for exploiting EVs for early cancer diagnosis and therapy. EVs (EVs) are a part of the cell secretome with a lipid-bilayered vesicular structure containing cellular cargo of lipids, proteins, and nucleic acids. All cells secrete heterogeneous populations of EVs which differ by size range (50-1000 nm) and sub-cellular origin (plasma membrane, endosome). Exosomes, which are often reported in the literature are a subtype of EVs with a typical size range of 50-200 nm and endosomal sub-cellular origin. As recommended by the International Society of Extracellular Vesicles (ISEV), we prefer to use “extracellular vesicles” unless the study provides clear evidence of identification of specific sub-type of EVs.

This special issue aims to add to the understanding of the role of EVs in early cancer diagnosis and therapy, and seek answers to some of the important issues in the field: How many roles do EVs have in cancer progression? Does all sub-type of EVs contribute to cancer progression? Is there a difference between the role of small EVs/large EVs in cancer progression? Can we block EV secretion as a therapeutic strategy? Can we use EVs as drug delivery agents and therapeutic targets against cancer? How do normal cell-secreted EVs vary from cancer cell-secreted EVs? Does the physicochemical environment alter EV secretion? Within this aim and scope, in this special issue of “Extracellular Vesicles for Early Cancer Diagnosis and Therapy”, we welcome original research articles and reviews from diverse backgrounds and expertise working in the field of EVs. Research areas may include (but are not limited to) the characterization of different sub-types of EVs, the role of EVs in cancer progression, engineering EVs for cancer-targeted drug delivery, EVs as cancer therapeutic targets, and EVs-based biomarker discovery for early diagnosis of cancer. We look forward to receiving your contribution.

Dr. Santosh Aryal
Dr. Sagar Rayamajhi
Guest Editors

Manuscript Submission Information

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  • extracellular vesicles sub-types
  • extracellular vesicles for drug delivery
  • extracellular vesicles as cancer therapeutic target
  • extracellular vesicles-based biomarkers

Published Papers (1 paper)

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Exosome Cargos as Biomarkers for Diagnosis and Prognosis of Hepatocellular Carcinoma
Pharmaceutics 2023, 15(9), 2365; https://doi.org/10.3390/pharmaceutics15092365 - 21 Sep 2023
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Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. Due to the insidiousness of HCC onset and the lack of specific early-stage markers, the early diagnosis and treatment of HCC are still unsatisfactory, leading to a poor prognosis. Exosomes are a [...] Read more.
Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. Due to the insidiousness of HCC onset and the lack of specific early-stage markers, the early diagnosis and treatment of HCC are still unsatisfactory, leading to a poor prognosis. Exosomes are a type of extracellular vesicle containing various components, which play an essential part in the development, progression, and metastasis of HCC. A large number of studies have demonstrated that exosomes could serve as novel biomarkers for the diagnosis of HCC. These diagnostic components mainly include proteins, microRNAs, long noncoding RNAs, and circular RNAs. The exosome biomarkers showed high sensitivity and high specificity in distinguishing HCC from health controls and other liver diseases, such as chronic HBV and liver cirrhosis. The expression of these biomarkers also exhibits correlations with various clinical factors such as tumor size, TMN stage, overall survival, and recurrence rate. In this review, we summarize the function of exosomes in the development of HCC and highlight their application as HCC biomarkers for diagnosis and prognosis prediction. Full article
(This article belongs to the Special Issue Extracellular Vesicles for Early Cancer Diagnosis and Therapy)
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