Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
6.9
5.4
Journals
Pharmaceutics
Special Issues
Magnetic Nanoparticles: Tools for Drug Delivery, Therapy and Imaging
share announcement

Magnetic Nanoparticles: Tools for Drug Delivery, Therapy and Imaging

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 697

Special Issue Editor

Dr. Eleni Efthimiadou

E-Mail Website
Guest Editor
Inorganic Chemistry Laboratory, Chemistry Department, National and Kapodistrian University of Athens, Panepistimiopolis, 157 71 Zografou, Greece
Interests: magnetic nanoparticles; drug delivery; theranostic; hyperthermia; cytotoxicity; in vitro evaluation; in vivo evaluation

Special Issue Information

Dear Colleagues,

Magnetic nanoparticle applications in the domain of personalized medicine through diagnosis and therapy have attracted tremendous interest in the scientific community. These nanoparticles are highly stable and have been successfully studied for the delivery of hydrophobic and hydrophilic entities in combination with real-time monitoring and targeted release under the application of a magnetic field. This behavior is the start of a big roadmap about the mechanisms of magnetic nanoparticle cell interactions. Different parameters will be taken into consideration like shape, size composition and surface chemistry.

In this Special Issue, we kindly invite authors to report experimental and theoretical results about novel magnetic nanoparticles and their mechanisms on drug release, mechanism diagnosis and therapy.

Dr. Eleni Efthimiadou
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • magnetic nanoparticles
  • magnetic hyperthermia
  • internalization mechanisms
  • in vitro evaluation
  • drug delivery
  • diagnostic techniques
  • therapeutic approaches
  • in vivo studies

Published Papers (1 paper)

Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

13 pages, 2931 KiB  
Article
Iron Oxide Nanoparticles: Selectively Targeting Melanoma Cells In Vitro by Inducing DNA Damage via H2AX Phosphorylation and Hindering Proliferation through ERK Dephosphorylation
by Danai E. Prokopiou, Anastasia Chillà, Francesca Margheri, Gabriella Fibbi, Anna Laurenzana and Eleni K. Efthimiadou
Pharmaceutics 2024, 16(4), 527; https://doi.org/10.3390/pharmaceutics16040527 - 11 Apr 2024
Viewed by 399
Abstract
This study investigates the distinctive characteristics of iron oxide magnetic nanoparticles (mNPs) and their potential application in cancer therapy, focusing on melanoma. Three types of mNPs, pre-validated for safety, underwent molecular analysis to uncover the activated signaling pathways in melanoma cells. Using the [...] Read more.
This study investigates the distinctive characteristics of iron oxide magnetic nanoparticles (mNPs) and their potential application in cancer therapy, focusing on melanoma. Three types of mNPs, pre-validated for safety, underwent molecular analysis to uncover the activated signaling pathways in melanoma cells. Using the Western blot technique, the study revealed that mNPs induce cytotoxicity, hinder proliferation through ERK1/2 dephosphorylation, and prompt proapoptotic effects, including DNA damage by inducing H2AX phosphorylation. Additionally, in vitro magnetic hyperthermia notably enhanced cellular damage in melanoma cells. Moreover, the quantification of intracellular iron levels through Inductively Coupled Plasma Mass Spectrometry (ICP-MS) analysis unveils the precise dosage required to induce cellular damage effectively. These compelling findings not only shed light on the therapeutic potential of mNPs in melanoma treatment but also open exciting avenues for future research, heralding a new era in the development of targeted and effective cancer therapies. Indeed, by discerning the effective dose, our approach becomes instrumental in optimizing the therapeutic utilization of iron oxide magnetic nanoparticles, enabling the induction of precisely targeted and controlled cellular responses. Full article
(This article belongs to the Special Issue Magnetic Nanoparticles: Tools for Drug Delivery, Therapy and Imaging)
►▼ Show Figures

Graphical abstract

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-1
Back to TopTop