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Special Issue "Biomimetic Nanoparticles for Disease Treatment and Diagnosis"

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Dear Colleagues,

Biomimetic nanoparticles are a new group of nanoparticles that combine the functionality of biological materials with the flexibility of synthetic materials to overcome biological barriers and achieve improved targeting in complex biological systems. These biomimetic platforms include cell membrane-coated nanoparticles, DNA nanodevices, and other hybrid nanoparticles. They have demonstrated significant potential to increase therapeutic efficacy in disease treatment and diagnosis by combining natural biological functionality with the ability of synthetic structures to transport imaging reporters and therapeutic cargo. In addition, the incorporation of cell-based biological materials offers benefits such as immune escape, prolonged blood circulation time, and specific/precise targeting.

This Special Issue aims to provide a platform for prominent scientists from all over the world to showcase their work and discuss current progress in the use of biomimetic nanoparticles for biomedical applications.

Dr. Tianqing (Michelle) Liu
Guest Editor

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Keywords

biomimetic nanoparticles
nanostructure
coating materials
functionalization
programmable biomaterials
biological functions
targeting
biological membranes
DNA nanodevices
peptides and proteins
lipid
therapy
diagnosis

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Open AccessReview

Bio-Inspired Nanocarriers Derived from Stem Cells and Their Extracellular Vesicles for Targeted Drug Delivery

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Pharmaceutics 2023, 15(7), 2011; https://doi.org/10.3390/pharmaceutics15072011 - 24 Jul 2023

Viewed by 723

Abstract

With their seemingly limitless capacity for self-improvement, stem cells have a wide range of potential uses in the medical field. Stem-cell-secreted extracellular vesicles (EVs), as paracrine components of stem cells, are natural nanoscale particles that transport a variety of biological molecules and facilitate cell-to-cell communication which have been also widely used for targeted drug delivery. These nanocarriers exhibit inherent advantages, such as strong cell or tissue targeting and low immunogenicity, which synthetic nanocarriers lack. However, despite the tremendous therapeutic potential of stem cells and EVs, their further clinical application is still limited by low yield and a lack of standardized isolation and purification protocols. In recent years, inspired by the concept of biomimetics, a new approach to biomimetic nanocarriers for drug delivery has been developed through combining nanotechnology and bioengineering. This article reviews the application of biomimetic nanocarriers derived from stem cells and their EVs in targeted drug delivery and discusses their advantages and challenges in order to stimulate future research. Full article

(This article belongs to the Special Issue Biomimetic Nanoparticles for Disease Treatment and Diagnosis)

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Open AccessReview

Research Progress of Neutrophil-Mediated Drug Delivery Strategies for Inflammation-Related Disease

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Pharmaceutics 2023, 15(7), 1881; https://doi.org/10.3390/pharmaceutics15071881 - 04 Jul 2023

Cited by 1 | Viewed by 658

Abstract

As the most abundant white blood cells in humans, neutrophils play a key role in acute and chronic inflammation, suggesting that these cells are a key component of targeted therapies for various inflammation-related diseases. Specific enzyme-responsive or specific ligand-modified polymer nanoparticles are beneficial for improving drug efficacy, reducing toxicity, and enhancing focal site retention. However, there remain significant challenges in biomedical applications of these synthetic polymer nanoparticles, mainly due to their rapid clearance by the reticuloendothelial system. In recent years, biomimetic drug delivery systems such as neutrophils acting directly as drug carriers or neutrophil-membrane-coated nanoparticles have received increasing attention due to the natural advantages of neutrophils. Thus, neutrophil-targeted, neutrophil-assisted, or neutrophil-coated nanoparticles exhibit a prolonged blood circulation time and improved accumulation at the site of inflammation. Despite recent advancements, further clinical research must be performed to evaluate neutrophil-based delivery systems for future biomedical application in the diagnosis and treatment of related inflammatory diseases. In this review, we have summarized new exciting developments and challenges in neutrophil-mediated drug delivery strategies for treating inflammation-related diseases. Full article

(This article belongs to the Special Issue Biomimetic Nanoparticles for Disease Treatment and Diagnosis)

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Special Issue "Biomimetic Nanoparticles for Disease Treatment and Diagnosis"

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