Special Issue "Exploring Natural Metabolites to Identify Novel Potential Therapeutic Agents"
Deadline for manuscript submissions: 20 February 2024 | Viewed by 3929
Historically, natural products have played a crucial role in drug discovery, especially for cancer and infectious diseases, but also in other therapeutic areas, including cardiovascular diseases, inflammation, and neurological disorders.
Today, many drugs on the market were discovered from natural sources, and in this context a key role is represented by plant secondary metabolites and microorganisms, which represent fascinating and unique sources of bioactive compounds with a wide range of activity.
These secondary metabolites are active compounds that are biosynthetically derived from primary metabolites. Many plant secondary metabolites are constitutive, and their common roles in plants are in defense and adaptation to the environment, and many of them are repellent or toxic to herbivores and pathogens, and thus protect plants from their attacks. Microbial secondary metabolites are low-molecular-mass molecules with heterogeneous structures produced during the late growth phase of microorganisms.
Based on their chemical nature, these metabolites can be classified into different categories: terpenoids and steroids, alkaloids, non-ribosomal polypeptides, fatty-acid-derived substances and polyketides, and shikimate-derived compounds. All these compounds have different bioactivities, and have always been studied for their pharmaceutical efficacy on human health, and have constantly played a pivotal role in the design and development of powerful therapeutic agents.
In summary, natural metabolites play a significant role in the design and development of novel powerful therapeutic agents because of their functions and unique structures, because of which they can be considered the cornerstone of drug discovery.
This Special Issue, “Exploring natural metabolites to identify novel potential therapeutic agents”, aims to collect papers concerning the identification, discovery, analysis and/or activity of new biologically active metabolites from microorganisms and plants; in addition, a particular focus on new achievements in the field will be appreciated. Reviews and future perspectives are also welcome.
Dr. Francesca Alessandra Ambrosio
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- hit identification
- marine microorganisms
- computational approaches
- in vivo/in vitro assays
- active metabolites
- drug discovery
- natural products
- functional foods