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Pathogens
Special Issues
New Approaches to Combating Multidrug-Resistant Pathogens
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New Approaches to Combating Multidrug-Resistant Pathogens

A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Bacterial Pathogens".

Deadline for manuscript submissions: 20 June 2024 | Viewed by 665

Special Issue Editor

Prof. Dr. Yuan Liu

E-Mail Website
Guest Editor
College of Veterinary Medicine, Yangzhou University, Yangzhou, China
Interests: antimicrobial resistance; novel antibacterial strategies

Special Issue Information

Dear Colleagues,

The increasing incidence of infections caused by multidrug-resistant pathogens in the clinical setting is a global concern. More alarmingly, the scarcity of novel approved antibiotics with distinct mechanisms of action aggravates this crisis in the post-antibiotic era. There is an urgent need to develop novel antibacterial strategies, including the repurposing of existing drugs and expansion of combination therapy to deal with this problem. New approaches include, but are not limited to, the following aspects: (1) identification of novel antibacterial agents through screening from natural products, de novo synthesis, chemical modification and optimization of identified compounds; (2) discovery of novel antibiotic adjuvants from unexplored molecules or previously approved compounds to rescue the effectiveness of existing antibiotics, as well as reduce their toxicity; (3) novel alternatives to antibiotics, such as antimicrobial peptides, probiotics, antivirulence agents and phages.

For this Special Issue, we invite you to send original or review papers on aspects of novel antibacterial strategies against multidrug-resistant pathogens.

Prof. Dr. Yuan Liu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pathogens is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antibacterial agents
  • antibiotic adjuvant
  • antibiotic alternatives
  • drug-resistant pathogens
  • multidrug-resistant pathogens

Published Papers (1 paper)

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Research

11 pages, 571 KiB  
Communication
A Proof-of-Concept Protein Microarray-Based Approach for Serotyping of Salmonella enterica Strains
by Sascha D. Braun, Elke Müller, Katrin Frankenfeld, Dominik Gary, Stefan Monecke and Ralf Ehricht
Pathogens 2024, 13(5), 355; https://doi.org/10.3390/pathogens13050355 (registering DOI) - 25 Apr 2024
Viewed by 290
Abstract
Salmonella enterica, a bacterium causing foodborne illnesses like salmonellosis, is prevalent in Europe and globally. It is found in food, water, and soil, leading to symptoms like diarrhea and fever. Annually, it results in about 95 million cases worldwide, with increasing antibiotic [...] Read more.
Salmonella enterica, a bacterium causing foodborne illnesses like salmonellosis, is prevalent in Europe and globally. It is found in food, water, and soil, leading to symptoms like diarrhea and fever. Annually, it results in about 95 million cases worldwide, with increasing antibiotic resistance posing a public health challenge. Therefore, it is necessary to detect and serotype Salmonella for several reasons. The identification of the serovars of Salmonella enterica isolates is crucial to detect and trace outbreaks and to implement effective control measures. Our work presents a protein-based microarray for the rapid and accurate determination of Salmonella serovars. The microarray carries a set of antibodies that can detect different Salmonella O- and H-antigens, allowing for the identification of multiple serovars, including Typhimurium and Enteritidis, in a single miniaturized assay. The system is fast, economical, accurate, and requires only small sample volumes. Also, it is not required to maintain an extensive collection of sera for the serotyping of Salmonella enterica serovars and can be easily expanded and adapted to new serovars and sera. The scientific state of the art in Salmonella serotyping involves the comparison of traditional, molecular, and in silico methods, with a focus on economy, multiplexing, accuracy, rapidity, and adaptability to new serovars and sera. The development of protein-based microarrays, such as the one presented in our work, contributes to the ongoing advancements in this field. Full article
(This article belongs to the Special Issue New Approaches to Combating Multidrug-Resistant Pathogens)
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