New Insights into Brucellosis and Other Abortive Diseases in Ruminants

A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Bacterial Pathogens".

Deadline for manuscript submissions: closed (30 April 2023) | Viewed by 1734

Special Issue Editor


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Guest Editor
Instituto de Patobiologia (IP), Instituto Nacional de Tecnologia Agropecuaria (INTA), Hurlingham B1686, Bs. As., Argentina
Interests: abortion; experimental models; pathogenesis; diagnostic techniques; therapeutics

Special Issue Information

Dear Colleagues,

Brucellosis is a bacterial zoonotic disease that causes abortions in ruminants. Together with many other bacterial, viral and parasitic agents that cause abortive diseases, they are the main concerns of the livestock sector and are responsible for great economic losses in the world economy. This is an important area in Veterinary Medicine that arouses special interest with multiple aspects to be elucidated.

I am pleased to invite you to contribute with your research from the different points of view of the life science such as biology, pharmacology, epidemiology, biochemistry, microbiology and genetics, with the aim of providing tools for a better understanding of abortive diseases and pathogens, and contributing to their control in ruminants.

In this Special Issue, original research articles, short communications and reviews are welcome. Research areas may include (but are not limited to) virulent factors and mechanisms of action, immunology studies revealing innate or acquired protection, novel diagnostic techniques, classical or alternative compounds to prevent or treat abortive diseases in different ruminant species, identification of new protective antigens, models for the study of the host:pathogen interaction and epidemiological studies, risk factors and economic impact. I look forward to your contribution.

Dr. Carlos A. Rossetti
Guest Editor

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Published Papers (1 paper)

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Research

25 pages, 3789 KiB  
Article
The Immune Response in the Uteri and Placentae of Chlamydia abortus-Infected Ewes and Its Association with Pregnancy Outcomes
by Sergio Gaston Caspe, David Andrew Ewing, Morag Livingstone, Clare Underwood, Elspeth Milne, Neil Donald Sargison, Sean Ranjan Wattegedera and David Longbottom
Pathogens 2023, 12(6), 846; https://doi.org/10.3390/pathogens12060846 - 19 Jun 2023
Cited by 1 | Viewed by 1261
Abstract
The enzootic abortion of ewes, caused by the bacterium Chlamydia abortus (C. abortus), is one of the main causes of abortion in sheep. There are multiple contributory factors, including chlamydial growth, host immune response, and hormonal balance, that result in different [...] Read more.
The enzootic abortion of ewes, caused by the bacterium Chlamydia abortus (C. abortus), is one of the main causes of abortion in sheep. There are multiple contributory factors, including chlamydial growth, host immune response, and hormonal balance, that result in different pregnancy outcomes, such as abortion, the birth of weak lambs that may die, or healthy lambs. This study aimed to determine the relationship between phenotypical patterns of immune cell infiltration and different pregnancy outcomes in twin-bearing sheep (both lambs born dead; one alive and one dead; both alive) when experimentally infected with C. abortus. Both the sheep uteri and placentae were collected after parturition. All samples were analysed for specific immune cell features, including cell surface antigens and the T-regulatory (Treg) cell-associated transcription factor and cytokines, by immunohistochemistry and in situ hybridisation. Some of these immunological antigens were evaluated in ovine reproductive tissues for the first time. Differential patterns of T helper/Treg cells revealed significant group effects in the placentae. It suggests the potential role that the balance of lymphocyte subsets may play in affecting different pregnancy outcomes in C. abortus-infected sheep. The present study provides novel detailed information about the immune responses observed at the maternofoetal interface in sheep at the time of pre-term abortion or lambing. Full article
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