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Pathogens
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Multidrug-Resistant Staphylococcus aureus
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Multidrug-Resistant Staphylococcus aureus

A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Bacterial Pathogens".

Deadline for manuscript submissions: 31 July 2024 | Viewed by 1881

Special Issue Editor

Prof. Dr. Hussein Hasan Abulreesh

E-Mail Website
Guest Editor
Department of Biology, Faculty of Applied Science, Umm Al-Qura University, Makkah, Saudi Arabia
Interests: public health microbiology; infectious diseases; antimicrobial resistance; environmental microbiology

Special Issue Information

Dear Colleagues,

Staphylococcus aureus is a Gram-positive cocci arranged in grape-like clusters that is a common inhabitant of the skin and upper respiratory tract in humans and animals. Although S. aureus is considered to be a common commensal of the human microbial flora, it can act as an important pathogen. S. aureus is a common cause of various skin and soft tissue infections including boils, impetigo, folliculitis and scalded skin syndrome. S. aureus is also implicated in bone and joint infections, bacteremia, pneumonia, food poisoning and fatal infections such as toxic shock syndrome. It is estimated that more than 50,000 deaths in the USA alone are associated with S. aureus infections. The treatment of S. aureus infections may be difficult due to ever-emerging antibiotic-resistant strains. Methicillin-resistant Staphylococcus aureus (MRSA) has become a difficult pathogen to combat, especially when it exhibits multidrug-resistant attributes to drugs currently used for treatment other than beta-lactams (e.g., vancomycin, gentamicin, linezolid or clindamycin). Thus, MRSA has been commonly associated with hospital-acquired Staphylococcus aureus infections (HA-Staphylococcus aureus) and is frequently increasing in community-associated Staphylococcus aureus infections (CA-Staphylococcus aureus). It is believed that infection due to MRSA is the second leading cause of mortality associated with antimicrobial resistance in recent years. Mechanisms of antimicrobial resistance in S. aureus vary between enzymatic inactivation of the antibiotic, alteration of the target, and trapping of the antibiotic and the efflux pump.  

For this Special Issue, we invite you to send original or review papers on various aspects of multidrug-resistant Staphylococcus aureus.

Prof. Dr. Hussein Hasan Abulreesh
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pathogens is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Staphylococcus aureus infections and antimicrobial resistance
  • hospital-acquired Staphylococcus aureus infections and antimicrobial resistance
  • community-associated Staphylococcus aureus infections and antimicrobial resistance
  • antimicrobial-resistant Staphylococcus aureus
  • resistance mechanisms in Staphylococcus aureus
  • epidemiology of multidrug-resistant Staphylococcus aureus
  • association between biofilm and multidrug resistance in Staphylococcus aureus

Published Papers (1 paper)

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Research

17 pages, 364 KiB  
Article
Detection of mecA Genes in Hospital-Acquired MRSA and SOSA Strains Associated with Biofilm Formation
by Rosa González-Vázquez, María Guadalupe Córdova-Espinoza, Alejandro Escamilla-Gutiérrez, María del Rocío Herrera-Cuevas, Raquel González-Vázquez, Ana Laura Esquivel-Campos, Laura López-Pelcastre, Wendoline Torres-Cubillas, Lino Mayorga-Reyes, Felipe Mendoza-Pérez, María Angélica Gutiérrez-Nava and Silvia Giono-Cerezo
Pathogens 2024, 13(3), 212; https://doi.org/10.3390/pathogens13030212 - 28 Feb 2024
Viewed by 1355
Abstract
Methicillin-resistant (MR) Staphylococcus aureus (SA) and others, except for Staphylococcus aureus (SOSA), are common in healthcare-associated infections. SOSA encompass largely coagulase-negative staphylococci, including coagulase-positive staphylococcal species. Biofilm formation is encoded by the icaADBC operon and is involved in virulence. mecA encodes an additional [...] Read more.
Methicillin-resistant (MR) Staphylococcus aureus (SA) and others, except for Staphylococcus aureus (SOSA), are common in healthcare-associated infections. SOSA encompass largely coagulase-negative staphylococci, including coagulase-positive staphylococcal species. Biofilm formation is encoded by the icaADBC operon and is involved in virulence. mecA encodes an additional penicillin-binding protein (PBP), PBP2a, that avoids the arrival of β-lactams at the target, found in the staphylococcal cassette chromosome mec (SCCmec). This work aims to detect mecA, the bap gene, the icaADBC operon, and types of SCCmec associated to biofilm in MRSA and SOSA strains. A total of 46% (37/80) of the strains were S. aureus, 44% (35/80) S. epidermidis, 5% (4/80) S. haemolyticus, 2.5% (2/80) S. hominis, 1.25% (1/80) S. intermedius, and 1.25% (1/80) S. saprophyticus. A total of 85% were MR, of which 95.5% showed mecA and 86.7% β-lactamase producers; thus, Staphylococcus may have more than one resistance mechanism. Healthcare-associated infection strains codified type I-III genes of SCCmec; types IV and V were associated to community-acquired strains (CA). Type II prevailed in MRSA mecA strains and type II and III in MRSOSA (methicillin-resistant staphylococci other than Staphylococcus aureus). The operon icaADBC was found in 24% of SA and 14% of SOSA; probably the arrangement of the operon, fork formation, and mutations influenced the variation. Methicillin resistance was mainly mediated by the mecA gene; however, there may be other mechanisms that also participate, since biofilm production is related to genes of the icaADBC operon and methicillin resistance was not associated with biofilm production. Therefore, it is necessary to strengthen surveillance to prevent the spread of these outbreaks both in the nosocomial environment and in the community. Full article
(This article belongs to the Special Issue Multidrug-Resistant Staphylococcus aureus)
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