Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
5.1
3.7
Journals
Pathogens
Special Issues
Update on Animal Pathogenic Escherichia coli
share announcement

Update on Animal Pathogenic Escherichia coli

A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Bacterial Pathogens".

Deadline for manuscript submissions: 31 May 2024 | Viewed by 1324

Special Issue Editor

Dr. Abraham Fikru Mechesso

E-Mail Website
Guest Editor
Department of Pathology and Microbiology, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198-5900, USA
Interests: antimicrobial resistance; animals; Escherichia coli; genetic profile; virulence

Special Issue Information

Dear Colleagues,

Escherichia coli is a ubiquitous commensal and a major pathogen in warm-blooded animals and humans. The bacterium is a highly successful competitor in the gut microflora, comprising the most abundant facultative anaerobe. Pathogenic and antimicrobial-resistant strains of E. coli have spread widely, and a significant number of acute E. coli infections are known to have zoonotic origins. Resistance to critically important antimicrobials such as extended-spectrum cephalosporins and carbapenems has been reported in E. coli isolated from diverse sources, including companion animals and food-producing animals. In addition, the bacterium contains many pathotypes that cause enteric disease and extra-intestinal infections, including urinary tract infections and meningitis. Therefore, understanding the genetic profiles and ecological origins of this bacterium has become increasingly important. I invite you to submit original and review articles related to the above topics. This Special Issue will provide new insights into the genetic profiles of antimicrobial-resistant and pathogenic strains of E. coli, which is vital to control E. coli-related diseases in animals as well as humans.

Dr. Abraham Fikru Mechesso
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pathogens is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antimicrobial resistance
  • animals
  • Escherichia coli
  • genetic profile
  • host–pathogen interaction
  • virulence factors

Published Papers (1 paper)

Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

13 pages, 8418 KiB  
Article
Characterization of an Escherichia coli Isolate Coharboring the Virulence Gene astA and Tigecycline Resistance Gene tet(X4) from a Dead Piglet
by Jianmei Wang, Yuting Huang, Chunjiu Guan, Jie Li, Hua Yang, Guoping Zhao, Canying Liu, Jiangang Ma and Biao Tang
Pathogens 2023, 12(7), 903; https://doi.org/10.3390/pathogens12070903 - 03 Jul 2023
Viewed by 1088
Abstract
tet(X4) is the critical resistance gene for tigecycline degradation that has been continually reported in recent years. In particular, pathogenic bacteria carrying tet(X4) are a severe threat to human health. However, information describing Escherichia coli coharboring tet(X4) with virulence genes [...] Read more.
tet(X4) is the critical resistance gene for tigecycline degradation that has been continually reported in recent years. In particular, pathogenic bacteria carrying tet(X4) are a severe threat to human health. However, information describing Escherichia coli coharboring tet(X4) with virulence genes is limited. Here, we isolated an E. coli strain coharboring tet(X4) and the heat-stable toxin gene astA from a dead piglet. The strain named 812A1-131 belongs to ST10. The genome was sequenced using the Nanopore and Illumina platforms. The virulence genes astA and tet(X4) are located on the chromosome and in the IncHI1-type plasmid p812A1-tetX4-193K, respectively. The plasmid could be conjugatively transferred to recipient E. coli J53 with high frequency. In vivo experiments showed that strain 812A1-131 is pathogenic to Galleria mellonella and could colonize the intestines of mice. In summary, pathogenic E. coli could receive a plasmid harboring the tet(X4) gene, which can increase the difficulty of treatment. The prevalence and transmission mechanisms of pathogenic bacteria coharboring the tet(X4) gene need more attention. Full article
(This article belongs to the Special Issue Update on Animal Pathogenic Escherichia coli)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-1
Back to TopTop