Modulation of Gut Microbiota and Pathogens by Biotics (Prebiotics, Probiotics, Postbiotics, Parabiotics, Synbiotics)

A special issue of Pathogens (ISSN 2076-0817).

Deadline for manuscript submissions: 30 August 2024 | Viewed by 1137

Special Issue Editors


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Guest Editor
Research Unit Bacterial Communication and Anti-Infectious Strategies (CBSA, UR4312), University of Rouen Normandie, 27000 Evreux, France
Interests: gut microbiota; gut-brain axis; host-microbe interactions; probiotics; health benefits; virulence; antibiotic resistance; safety
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Research Unit Bacterial Communication and Anti-Infectious Strategies (CBSA, UR4312), University of Rouen Normandie, 27000 Evreux, France
Interests: gut-brain axis; host-microbe interactions; microbial ecology, microbial genomics, next generation sequencing

Special Issue Information

Dear Colleagues,

Gut microbiota plays an important role in maintaining host health, helping to defend against pathogens and modulate the immune response. A favourable balance of the gut microbiota is therefore beneficial to the host's health. Biotics are powerful regulators of gut microbiota and have a positive effect on host health by preventing pathogen invasion, modulating the host immunity and protecting from several infectious and non-infectious diseases. Thus, the potential roles of biotics in affecting gut bacteria communities and the immune system are considered an economical and safe alternative for the treatment of some chronic diseases and improvement of human health.

This Special Issue discusses the role of the gut microbiota and the use of biotics (prebiotics, probiotics, postbiotics, parabiotics and synbiotics) as novel therapies for the prevention of pathogens, treatment of infections and modulation of gut microbiota. We will consider original scientific research articles, comprehensive reviews, commentaries and perspectives for publication, which aim to identify new opportunities and advance the field. Topics of interest include gut microbiota, host–microbe interactions, and host adaptation, all being related to the role of biotics in the modulation of gut microbiota and pathogens. All manuscripts will be peer-reviewed.

We look forward to your submission.

Dr. Nathalie Connil
Dr. Amine Boukerb
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gut microbiota
  • therapies
  • pathogens prevention
  • infections treatment
  • immune system
  • probiotics
  • prebiotics
  • postbiotics

Published Papers (1 paper)

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Research

17 pages, 3155 KiB  
Article
Commensal Bacteria Impact on Intestinal Toll-like Receptor Signaling in Salmonella-Challenged Gnotobiotic Piglets
by Alla Splichalova, Zdislava Kindlova, Jiri Killer, Vera Neuzil Bunesova, Eva Vlkova, Barbora Valaskova, Radko Pechar, Katerina Polakova and Igor Splichal
Pathogens 2023, 12(11), 1293; https://doi.org/10.3390/pathogens12111293 - 29 Oct 2023
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Abstract
Gnotobiotic (GN) animals with simple and defined microbiota can help to elucidate host-pathogen interferences. Hysterectomy-derived germ-free (GF) minipigs were associated at 4 and 24 h post-hysterectomy with porcine commensal mucinolytic Bifidobacterium boum RP36 (RP36) strain or non-mucinolytic strain RP37 (RP37) or at 4 [...] Read more.
Gnotobiotic (GN) animals with simple and defined microbiota can help to elucidate host-pathogen interferences. Hysterectomy-derived germ-free (GF) minipigs were associated at 4 and 24 h post-hysterectomy with porcine commensal mucinolytic Bifidobacterium boum RP36 (RP36) strain or non-mucinolytic strain RP37 (RP37) or at 4 h post-hysterectomy with Lactobacillus amylovorus (LA). One-week-old GN minipigs were infected with Salmonella Typhimurium LT2 strain (LT2). We monitored histological changes in the ileum, mRNA expression of Toll-like receptors (TLRs) 2, 4, and 9 and their related molecules lipopolysaccharide-binding protein (LBP), coreceptors MD-2 and CD14, adaptor proteins MyD88 and TRIF, and receptor for advanced glycation end products (RAGE) in the ileum and colon. LT2 significantly induced expression of TLR2, TLR4, MyD88, LBP, MD-2, and CD14 in the ileum and TLR4, MyD88, TRIF, LBP, and CD14 in the colon. The LT2 infection also significantly increased plasmatic levels of inflammatory markers interleukin (IL)-6 and IL-12/23p40. The previous colonization with RP37 alleviated damage of the ileum caused by the Salmonella infection, and RP37 and LA downregulated plasmatic levels of IL-6. A defined oligo-microbiota composed of bacterial species with selected properties should probably be more effective in downregulating inflammatory response than single bacteria. Full article
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