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Pathogens
Special Issues
Antimicrobial Resistance in Bloodstream Infections: Epidemiology and Application of Rapid...
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Antimicrobial Resistance in Bloodstream Infections: Epidemiology and Application of Rapid Diagnostics

A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Bacterial Pathogens".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 1700

Special Issue Editors

Dr. Gabriele Bianco

E-Mail Website
Guest Editor
Dipartimento di Scienze della Sanità Pubblica e Pediatriche, Azienda Ospedaliera—Universitaria Città della Salute e della Scienza di Torino, Turin, Italy
Interests: clinical microbiology; rapid diagnostics; blood culture; antimicrobial resistance
Special Issues, Collections and Topics in MDPI journals
Dr. Sara Comini

E-Mail Website
Guest Editor
Microbiology and Virology Unit, University Hospital Città della Salute e della Scienza di Torino, Turin, Italy
Interests: antimicrobials; resistance mechanisms; rapid diagnostic testing; bloodstream infections

Special Issue Information

Dear Colleagues,

Bloodstream infections are serious medical conditions associated with high morbidity and mortality. Among the patients suffering from bloodstream infections, the effectiveness of empiric antibiotic therapy is complicated by the growing threat of antimicrobial resistance. Therefore, rapid microbiological diagnosis is of paramount importance, given the negative impact of delayed or inappropriate antimicrobial treatment. For this Special Issue, we invite authors to contribute original research and review papers describing the epidemiology of antimicrobial resistance in bloodstream infections and the application of rapid methods for blood culture diagnostics.

Dr. Gabriele Bianco
Dr. Sara Comini
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pathogens is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • blood cultures
  • bloodstream infections
  • antimicrobial resistance
  • rapid diagnostic testing
  • genotypic testing
  • phenotypic testing

Published Papers (1 paper)

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Research

15 pages, 1310 KiB  
Article
Bloodstream Infections by AmpC-Producing Enterobacterales: Risk Factors and Therapeutic Outcome
by Mladen Pospišil, Haris Car, Vesna Elveđi-Gašparović, Nataša Beader, Zoran Herljević and Branka Bedenić
Pathogens 2023, 12(9), 1125; https://doi.org/10.3390/pathogens12091125 - 03 Sep 2023
Viewed by 1389
Abstract
Bloodstream infections associated with AmpC-producing Enterobacterales are severe medical conditions which, without prompt and effective treatment, may have dire ramifications. This study aimed to assess whether certain comorbidities and previous surgical procedures coincide with resistance determinants of AmpC-producing Enterobacterales associated with bloodstream infections. [...] Read more.
Bloodstream infections associated with AmpC-producing Enterobacterales are severe medical conditions which, without prompt and effective treatment, may have dire ramifications. This study aimed to assess whether certain comorbidities and previous surgical procedures coincide with resistance determinants of AmpC-producing Enterobacterales associated with bloodstream infections. Antibiotic resistance patterns and therapy outcome were also determined. The patients’ data obtained revealed that the prevalence of recent surgical procedures, solid organ tumors, metabolic diseases, kidney and liver failure, and hematological malignancies do not differ between resistant and susceptible isolates of AmpC-producing Enterobacterales. Furthermore, no difference was reported in mortality rates. Regarding antibiotic resistance, 34.52% of isolates were confirmed to be resistant (AmpC hyperproduction, ESBL, or carbapenemase). More than one in five AmpC hyperproducers were reported amid Providencia spp., K. aerogenes, E. cloacae, and C. freundii. strains. Carbapenemases were mostly noted in Providencia spp. followed by M. morganii and K. aerogenes strains. Serratia marcescens had the highest proportion of ESBLsof ESBLs. Resistance to expanded-spectrum cephalosporins of Providencia spp. and K. aerogenes strains exceeded 50%, and resistance to meropenem over 10% was observed only in C. freundii strains. Enterobacterales’ ever-growing resistance to antibiotics is becoming quite a challenge for clinicians and new treatment options are required. Full article
(This article belongs to the Special Issue Antimicrobial Resistance in Bloodstream Infections: Epidemiology and Application of Rapid Diagnostics)
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