Antimicrobial Resistance in Bloodstream Infections: Epidemiology and Application of Rapid Diagnostics

A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Bacterial Pathogens".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 1972

Special Issue Editors


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Guest Editor
Dipartimento di Scienze della Sanità Pubblica e Pediatriche, Azienda Ospedaliera—Universitaria Città della Salute e della Scienza di Torino, Turin, Italy
Interests: clinical microbiology; rapid diagnostics; blood culture; antimicrobial resistance
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Guest Editor
Microbiology and Virology Unit, University Hospital Città della Salute e della Scienza di Torino, Turin, Italy
Interests: antimicrobials; resistance mechanisms; rapid diagnostic testing; bloodstream infections

Special Issue Information

Dear Colleagues,

Bloodstream infections are serious medical conditions associated with high morbidity and mortality. Among the patients suffering from bloodstream infections, the effectiveness of empiric antibiotic therapy is complicated by the growing threat of antimicrobial resistance. Therefore, rapid microbiological diagnosis is of paramount importance, given the negative impact of delayed or inappropriate antimicrobial treatment. For this Special Issue, we invite authors to contribute original research and review papers describing the epidemiology of antimicrobial resistance in bloodstream infections and the application of rapid methods for blood culture diagnostics.

Dr. Gabriele Bianco
Dr. Sara Comini
Guest Editors

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Keywords

  • blood cultures
  • bloodstream infections
  • antimicrobial resistance
  • rapid diagnostic testing
  • genotypic testing
  • phenotypic testing

Published Papers (1 paper)

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Research

15 pages, 1310 KiB  
Article
Bloodstream Infections by AmpC-Producing Enterobacterales: Risk Factors and Therapeutic Outcome
by Mladen Pospišil, Haris Car, Vesna Elveđi-Gašparović, Nataša Beader, Zoran Herljević and Branka Bedenić
Pathogens 2023, 12(9), 1125; https://doi.org/10.3390/pathogens12091125 - 3 Sep 2023
Viewed by 1637
Abstract
Bloodstream infections associated with AmpC-producing Enterobacterales are severe medical conditions which, without prompt and effective treatment, may have dire ramifications. This study aimed to assess whether certain comorbidities and previous surgical procedures coincide with resistance determinants of AmpC-producing Enterobacterales associated with bloodstream infections. [...] Read more.
Bloodstream infections associated with AmpC-producing Enterobacterales are severe medical conditions which, without prompt and effective treatment, may have dire ramifications. This study aimed to assess whether certain comorbidities and previous surgical procedures coincide with resistance determinants of AmpC-producing Enterobacterales associated with bloodstream infections. Antibiotic resistance patterns and therapy outcome were also determined. The patients’ data obtained revealed that the prevalence of recent surgical procedures, solid organ tumors, metabolic diseases, kidney and liver failure, and hematological malignancies do not differ between resistant and susceptible isolates of AmpC-producing Enterobacterales. Furthermore, no difference was reported in mortality rates. Regarding antibiotic resistance, 34.52% of isolates were confirmed to be resistant (AmpC hyperproduction, ESBL, or carbapenemase). More than one in five AmpC hyperproducers were reported amid Providencia spp., K. aerogenes, E. cloacae, and C. freundii. strains. Carbapenemases were mostly noted in Providencia spp. followed by M. morganii and K. aerogenes strains. Serratia marcescens had the highest proportion of ESBLsof ESBLs. Resistance to expanded-spectrum cephalosporins of Providencia spp. and K. aerogenes strains exceeded 50%, and resistance to meropenem over 10% was observed only in C. freundii strains. Enterobacterales’ ever-growing resistance to antibiotics is becoming quite a challenge for clinicians and new treatment options are required. Full article
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