Special Issue "Advances in the One Health Based on Helminthology Research"
Deadline for manuscript submissions: 8 August 2024 | Viewed by 266
Interests: taxonomy; scanning electron microscopy; immunology of infectious diseases; histopathology; parasitic diseases; immunology; biodiversity; evolution; ecology and evolution; tropical diseases
Helminths compose a complex and diverse group of macroparasites that can explore different environments. They spread by simple resistance structures, eggs, or within other organisms using their body (such as larvae or adult worms) as a definitive, intermediate, or paratenic host. Many of these parasites have a body mass very close to their host, and are always much larger than any eukaryotic cell. Challenges to understanding how these starving parasites can succeed without killing most of their hosts remain an important target of advanced helminthology. Expanding our knowledge of helminth diversity by exploring classical tools in association with advanced technologies could be a roadmap to attract funding and young researchers to the integrative taxonomy of helminths. As we expand the list of helminth parasites and detail their life cycles, more zoonoses and emerging and reemerging diseases are described. Helminths are important protagonists of the One Health concept, moving between the abiotic environment and intriguing sites and host tissues. Helminthology is a fascinating and important topic that must continue growing and advancing; therefore, we encourage you to submit your research to this Special Issue.
Dr. Eduardo José Lopes-Torres
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pathogens is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- molecular biology
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: Structural Characterization of Host-Parasite Interaction in Giant African Snail Achatina fulica Infected With Angiostrongylus cantonensis
Authors: Lopes-Torres Eduardo; Simões Raquel; Mota Ester; Thiengo Silvana
Affiliation: 1. Universidade do Estado do Rio de Janeiro; 2. Universidade Federal Rural do Rio de Janeiro; 3. Fundação Oswaldo Cruz.
Abstract: (1) Background: Angiostrongylus cantonensis is a nematode parasite of the pulmonary arteries of rodents, which are its definitive hosts. Achatina fulica, the African giant snail, is considered one of the most important intermediate hosts in the America. This helminth causes eosinophilic meningitis or meningoencephalitis in humans, an emergent disease in the Americas. The knowledge of the host-parasite relationship within the One Health Approach is extremely relevant, since zoonoses are closely intertwined in this complex mechanisms of wild/human hosts, parasite adaption and environmental dispersion. The objective of this study was to enrich our knowledge of the tissue biological mechanisms associated whit the defense of A. fulica against A. cantonensis. (2) Methods: Nine snails aged three months were randomly selected and exposed for 24 hours to a concentration of 2000 L1/dose of A. cantonensis. After necropsy, the samples were processed exploring new approaches using light and scanning electron microscopy. (3) Results: We show that the A. fulica presents a multifocal inflammatory process with granulomas distributed in different tissues (fig. 1), composed of granulocyte cells and granule clusters distributed in the region bordering the larvae. Scanning electron microscopy revealed details of the structure of the nematode (Fig. 2), suggesting that the granulomas may serve to protect the parasite against attack by the molluscan immune defense system. (4) Conclusions: The host-parasite process adaption is based on a complex balance between host resistance and parasite pathogenicity, and evolutionary adaptation is a key to this equation. Based on our results, we can suggest that the african invertebrate host and this Chinese nematode, when in the natural infection in Brazilian rodents, allowed the formation a granuloma, keeping the parasite alive, isolating it from the snail immune system, favoring the dispersal of the nematode, and preserving the host tissues.