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Pathogens
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Advances in the One Health Based on Helminthology Research
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Advances in the One Health Based on Helminthology Research

A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Parasitic Pathogens".

Deadline for manuscript submissions: 8 August 2024 | Viewed by 1443

Special Issue Editor

Dr. Eduardo José Lopes-Torres

E-Mail Website
Guest Editor
Laboratório de Helmintologia Romero Lascasas Porto, Faculdade de Ciências Médicas, Universidade do Estado do Rio de Janeiro, Rio de Janeiro 20511-070, Brazil
Interests: taxonomy; scanning electron microscopy; immunology of infectious diseases; histopathology; parasitic diseases; immunology; biodiversity; evolution; ecology and evolution; tropical diseases

Special Issue Information

Dear Colleagues,

Helminths compose a complex and diverse group of macroparasites that can explore different environments. They spread by simple resistance structures, eggs, or within other organisms using their body (such as larvae or adult worms) as a definitive, intermediate, or paratenic host. Many of these parasites have a body mass very close to their host, and are always much larger than any eukaryotic cell. Challenges to understanding how these starving parasites can succeed without killing most of their hosts remain an important target of advanced helminthology. Expanding our knowledge of helminth diversity by exploring classical tools in association with advanced technologies could be a roadmap to attract funding and young researchers to the integrative taxonomy of helminths. As we expand the list of helminth parasites and detail their life cycles, more zoonoses and emerging and reemerging diseases are described. Helminths are important protagonists of the One Health concept, moving between the abiotic environment and intriguing sites and host tissues. Helminthology is a fascinating and important topic that must continue growing and advancing; therefore, we encourage you to submit your research to this Special Issue.

Dr. Eduardo José Lopes-Torres
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pathogens is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • neglected
  • taxonomy
  • diagnosis
  • epidemiology
  • treatment
  • morphology
  • molecular biology
  • helminth

Published Papers (1 paper)

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Research

13 pages, 6716 KiB  
Article
A Structural Analysis of Host–Parasite Interactions in Achatina fulica (Giant African Snail) Infected with Angiostrongylus cantonensis
by Eduardo J. Lopes-Torres, Raquel de Oliveira Simões, Ester M. Mota and Silvana Carvalho Thiengo
Pathogens 2024, 13(1), 34; https://doi.org/10.3390/pathogens13010034 - 29 Dec 2023
Viewed by 1046
Abstract
Angiostrongylus cantonensis is a nematode parasite that resides in the pulmonary arteries of rodents, serving as its definitive hosts. The life cycle involves several species of non-marine gastropods as intermediate hosts, and the African giant snail Achatina fulica is considered one of the [...] Read more.
Angiostrongylus cantonensis is a nematode parasite that resides in the pulmonary arteries of rodents, serving as its definitive hosts. The life cycle involves several species of non-marine gastropods as intermediate hosts, and the African giant snail Achatina fulica is considered one of the most important around the world. Experimental data concerning A. cantonensis infection in the African giant snail remains notably limited. This helminth causes eosinophilic meningitis or meningoencephalitis in humans, representing an emergent zoonosis in Brazil. Understanding the host–parasite relationship through the application of new tools is crucial, given the complex interaction between zoonosis and the intricate mechanisms involving wild/human hosts, parasite adaptation, and dispersion. The objective of this study was to employ SEM as a novel methodology to understand the structural organization of the host tissue, particularly the granuloma formation. This sheds light on the complex balance between A. fulica and A. cantonensis. Nine three-month-old snails were randomly selected and exposed for 24 h to a concentration of 2000 L1/dose of A. cantonensis. A necropsy was performed 37 days after the infection, and the samples were examined using light and scanning electron microscopy (SEM). The histopathological results revealed third-stage larvae of A. cantonensis associated with granulomas distributed throughout the head-foot mass, mantle, and kidney. Scanning electron microscopy of the histological section surface showed that the granuloma is surrounded by a cluster of spherical particles, which are distributed in the region bordering the larvae. This reveal details of the nematode structure, demonstrating how this methodology can enhance our understanding of the role of granulomas in molluscan tissue. The structural characteristics of granuloma formation in A. fulica suggest it as an excellent invertebrate host for A. cantonensis. This relationship appears to provide protection to the parasite against the host’s immune defense system while isolating the snail’s tissue from potential exposure to nematode antigens. Full article
(This article belongs to the Special Issue Advances in the One Health Based on Helminthology Research)
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