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Pathogens
Special Issues
Host Immune Responses to Intracellular Pathogens
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Special Issue "Host Immune Responses to Intracellular Pathogens"

A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Immunological Responses and Immune Defense Mechanisms".

Deadline for manuscript submissions: 31 December 2023 | Viewed by 859

Special Issue Editors

Prof. Dr. Sergio Costa Oliveira

E-Mail Website
Guest Editor
Departamento de Imunologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil
Interests: innate immunity; inflammasomes; cytosolic sensors; STING; intracellular infections
Special Issues, Collections and Topics in MDPI journals
Dr. Guillermo Giambartolomei

E-Mail Website
Guest Editor
Instituto de Inmunología, Genética y Metabolismo (INIGEM), CONICET, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina
Interests: innate immunity; intracellular infections; immunopathology of CNS
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Innate immunity is the first arm of the immune system to be triggered in host defense against intracellular pathogens. Later, the adaptive immune response is activated and plays a major role in protection against infections; however, further studies are required to elucidate this complex circuit by which the host immune system recognizes and eliminates intracellular pathogens. Of particular interest is how intracellular pathogens escape innate immune recognition. These aspects of the host–parasite relationship will be discussed in this Special Issue, and the findings will help to advance the comprehension of host immune responses as well as pathogenesis and contribute to the future development of drugs or vaccines with which to control infections. For this Special Issue of Pathogens, we invite you to submit a review or research article related to host immune responses, inflammation, T and B cell responses, vaccine development, immune evasion, and the pathology as well as pathogenesis of bacterial, viral, fungal, or protozoan intracellular infections. We look forward to your contribution.

Prof. Dr. Sergio Costa Oliveira
Dr. Guillermo Giambartolomei
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pathogens is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • innate immunity
  • adaptive immunity
  • intracellular infections
  • bacteria
  • virus
  • protozoan parasites

Published Papers (2 papers)

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Research

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15 pages, 2798 KiB  
Article
Alterations of Plasma Biochemical and Immunological Parameters and Spatiotemporal Expression of TLR2 and TLR9 in Gibel Carp (Carassius auratus gibelio) after CyHV-2 Infection
by
Jinwei Gao
,
Yiwen Hu
,
Min Xie
,
Hao Wu
,
Jiayu Wu
,
Bingwen Xi
,
Rui Song
and
Dongsheng Ou
Pathogens 2023, 12(11), 1329; https://doi.org/10.3390/pathogens12111329 - 08 Nov 2023
Viewed by 316
Abstract
Cyprinid herpesvirus II (CyHV-2), a highly contagious pathogen of gibel carp (Carassius auratus gibelio), causes herpesviral hematopoietic necrosis disease (HVHND) and enormous financial losses. However, there is limited information available regarding the changes in plasma biochemical and immunological parameters and the [...] Read more.
Cyprinid herpesvirus II (CyHV-2), a highly contagious pathogen of gibel carp (Carassius auratus gibelio), causes herpesviral hematopoietic necrosis disease (HVHND) and enormous financial losses. However, there is limited information available regarding the changes in plasma biochemical and immunological parameters and the response characteristics of Toll-like receptor 2 (TLR2) and Toll-like receptor 9 (TLR9) in gibel carp after CyHV-2 infection. To address this knowledge gap, a sub-lethal CyHV-2 infection was conducted in gibel carp, and the sample was collected daily from 1 to 7 days post infection. The plasma biochemical analyses showed significant decreases in the content of glucose, total cholesterol (TCHO), and total protein (TP), along with marked increases in the level of uric acid, urea, creatinine (CREA), Complement 3 (C3), immunoglobulin D (IgD), and immunoglobulin M (IgM) as well as in the activity of alanine aminotransferase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), and lactate dehydrogenase (LDH) in the infected group. Compared with the control group, the concentration of cortisol, triglyceride (TG), and Complement 4 (C4) had no noticeable alterations in the infected group. Real-time quantitative PCR analysis showed significant upregulation of TLR2 and TLR9 mRNA expression in the spleen, kidney, brain, liver, intestine, and gill post CyHV-2 infection. Interestingly, a time- and tissue-dependent expression profile has been comparatively observed for TLR2 and TLR9 in the above tissues of gibel carp after CyHV-2 infection, suggesting distinct roles between TLR2 and TLR9 in antiviral response to CyHV-2 infection. Overall, our results demonstrated that CyHV-2 infection led to the disruption of the physiological metabolic process and damage to the liver and kidney, and induced different spatiotemporal expression patterns of TLR2 and TLR9, ultimately stimulating antiviral response via innate and adaptive immune system. These findings may provide a deeper understanding of the host immunity response to CyHV-2 infection and offer novel perspectives for the prevention and treatment and therapeutic drug development against CyHV-2. Full article
(This article belongs to the Special Issue Host Immune Responses to Intracellular Pathogens)
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Review

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17 pages, 2341 KiB  
Review
Current Understanding of Bacillus Calmette-Guérin-Mediated Trained Immunity and Its Perspectives for Controlling Intracellular Infections
by
Ana Carolina V. S. C. de Araujo
,
Fábio Mambelli
,
Rodrigo O. Sanches
,
Fábio V. Marinho
and
Sergio C. Oliveira
Pathogens 2023, 12(12), 1386; https://doi.org/10.3390/pathogens12121386 - 24 Nov 2023
Viewed by 237
Abstract
The bacillus Calmette–Guérin (BCG) is an attenuated bacterium derived from virulent Mycobacterium bovis. It is the only licensed vaccine used for preventing severe forms of tuberculosis in children. Besides its specific effects against tuberculosis, BCG administration is also associated with beneficial non-specific [...] Read more.
The bacillus Calmette–Guérin (BCG) is an attenuated bacterium derived from virulent Mycobacterium bovis. It is the only licensed vaccine used for preventing severe forms of tuberculosis in children. Besides its specific effects against tuberculosis, BCG administration is also associated with beneficial non-specific effects (NSEs) following heterologous stimuli in humans and mice. The NSEs from BCG could be related to both adaptive and innate immune responses. The latter is also known as trained immunity (TI), a recently described biological feature of innate cells that enables functional improvement based on metabolic and epigenetic reprogramming. Currently, the mechanisms related to BCG-mediated TI are the focus of intense research, but many gaps are still in need of elucidation. This review discusses the present understanding of TI induced by BCG, exploring signaling pathways that are crucial to a trained phenotype in hematopoietic stem cells and monocytes/macrophages lineage. It focuses on BCG-mediated TI mechanisms, including the metabolic-epigenetic axis and the inflammasome pathway in these cells against intracellular pathogens. Moreover, this study explores the TI in different immune cell types, its ability to protect against various intracellular infections, and the integration of trained innate memory with adaptive memory to shape next-generation vaccines. Full article
(This article belongs to the Special Issue Host Immune Responses to Intracellular Pathogens)
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