Epidemiology and Immunopathology of Intestinal Helminthiasis and Schistosomiasis: From Experimental Data to Field Work

A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Parasitic Pathogens".

Deadline for manuscript submissions: 15 October 2024 | Viewed by 1403

Special Issue Editors


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Guest Editor
Department of Parasitology, Institute for Biological Sciences, Federal University of Minas Gerais, Belo Horizonte 31270-901, MG, Brazil
Interests: immunoparasitology; helminthology; epidemiology; Schistosoma mansoni; soil-transmitted helminths

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Guest Editor
Department of Parasitology, Institute for Biological Sciences, Federal University of Minas Gerais, Belo Horizonte 31270-901, MG, Brazil
Interests: Schistosoma mansoni; Strongyloides stercoralis; immune response; pathology; diagnosis

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Guest Editor
National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20852, USA
Interests: helminth parasites;allergy; Th2 response; type-2 inflammation

Special Issue Information

Dear Colleagues,

There has been substantial progress in the control of soil-transmitted helminths (STH) and schistosomiasis in many regions of the globe, and the World Health Organization (WHO) intends to move forward towards elimination and eradication of some of these main neglected tropical diseases, as stated in their new roadmap for 2021-2030.

Nevertheless, there are still many unknowns in this vast area of research, for example, the interactions between the microbiota and intestinal helminth species and the consequences on the immune response and/or associated pathologies, as well as the tissue-specific immune response signatures driven by helminth parasites, or the still very scarce or obsolete information on the epidemiology of STH, including Strongyloides stercoralis, or even the challenging topic of epidemiology and sensitive diagnosis of schistosomiasis during an era of elimination as a public health problem. In this Special Issue of Pathogens (Impact factor 4.531), entitled ‘Epidemiology and Immunopathology of Intestinal Helminthiasis and Schistosomiasis: From Experimental Data to Field Work’, we want to create a platform for original research articles, short reports, as well as opinion pieces that highlight the epidemiology and immunopathology of STH and schistosomiasis, using both experimental data and recently developed field work.

We are looking forward to your contribution. Please contact us if you are considering submitting a manuscript.

Dr. Stefan Geiger
Prof. Dr. Deborah Aparecida Negrão-Corrêa
Dr. Pedro H. Gazzinelli-Guimaraes
Guest Editors

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Keywords

  • schistosomiasis
  • intestinal Helminths
  • epidemiology
  • immunoparasitology
  • pathology

Published Papers (1 paper)

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Research

10 pages, 634 KiB  
Article
Accurate Diagnosis of Schistosoma mansoni and S. haematobium from Filtered Urine Samples Collected in Tanzania, Africa
by Koreena Miller, Javeriya Choudry, El Shaimaa Mahmoud and Nilanjan Lodh
Pathogens 2024, 13(1), 59; https://doi.org/10.3390/pathogens13010059 - 08 Jan 2024
Viewed by 1178
Abstract
Schistosomiasis is a bloodborne, and waterborne parasitic disease caused by the human Schistosoma species, namely Schistosoma mansoni and S. haematobium. The parasite requires an intermediate snail host, where they grow and develop, along with a human host (definitive). Schistosoma egg detection in [...] Read more.
Schistosomiasis is a bloodborne, and waterborne parasitic disease caused by the human Schistosoma species, namely Schistosoma mansoni and S. haematobium. The parasite requires an intermediate snail host, where they grow and develop, along with a human host (definitive). Schistosoma egg detection in feces (S. mansoni) and urine (S. haematobium) are the WHO-recommended confirmatory diagnostic tests. The goal of our research was to determine the efficacy of detecting single or dual Schistosome species from filtered human urine samples collected in Tanzania by amplifying species-specific cell-free repeat DNA fragments via polymerase chain reaction (PCR) and gel electrophoresis. In total, 104 filtered human urine samples were evaluated and collected from individuals residing in the village of Kayenze, Tanzania. All samples were detected with 100% accuracy and no cross-amplification was present. For a single infection of S. mansoni, 22 (21%) of the samples were positive, while 15 (14%) of the samples were negative via PCR. Moreover, for a single infection of S. haematobium, 7 (7%) of the samples were positive, while 15 (14%) of the samples were negative. Dual infections were found in a higher percentage, with 60 (58%) of the samples being positive. Thus, we have justified that PCR is more sensitive and specific by amplifying species-specific cell-free repeat DNA fragments from the same urine sample than WHO-recommended methods of processing stool and urine. Full article
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