Interaction of Oxygen and Other Gases with Haem Containing Proteins
A special issue of Oxygen (ISSN 2673-9801).
Deadline for manuscript submissions: 31 August 2024 | Viewed by 1609
Special Issue Editor
Interests: redox signaling; reactive oxygen species; hydrogen sulfide; hydrogen gas; nitric oxide
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The interaction of molecular oxygen (O2) and haem-containing proteins has been known of for a long time. Oxygen is transiently bound by both haemoglobin and myoglobin in animals, as well as by globins, found in plants. Oxygen also binds to proteins with haem prosthetic groups which function as terminal electron acceptors, such as in the enzyme NADPH oxidase, which is instrumental in the generation of reactive oxygen species in animals and plants. Other gases, besides oxygen, interact with haem-containing proteins too. Carbon dioxide and carbon monoxide are two good examples, but several other gases are also known to cause similar effects. Inert gases, such as xenon (Xe), can bind to hydrophobic cavities and alter protein function, with the globin proteins being a good model system for the study of such effects. Nitric oxide (NO) is known to affect haem proteins, such as haemoglobin and guanylyl cyclase. More recently, molecular hydrogen (H2) has been found to cause significant biological effects, partly mediated by the removal of hydroxyl radicals. One mechanism suggested is the interaction of H2 with protein haem groups. Therefore, along with oxygen, several gases which are likely to be present in cells at the same time are able to interact with a range of proteins which contain haem, and their interplay and how they affect cellular function will no doubt be an area of interest in the foreseeable future.
Prof. Dr. John T. Hancock
Guest Editor
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Keywords
- oxygen oxygen transport and movement
- oxygen binding
- gasotransmitters haem (Heme)
- prosthetic groups
- guanylyl cyclase (Guanylate cyclase)
- NADPH oxidase
- carbon monoxide
- carbon dioxide
- electron transfer
- nitric oxide
- nitric oxide synthase
- xenon
- argon
- krypton
- hydrogen
- hydrogen sulfide
- hydrophobic cavities and pockets
- protein structure alterations
