Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Organics
Special Issues
Heterocyclic Compounds and Their Derivatives: Synthesis and Applications
share announcement

Heterocyclic Compounds and Their Derivatives: Synthesis and Applications

A special issue of Organics (ISSN 2673-401X).

Deadline for manuscript submissions: 30 June 2024 | Viewed by 1689

Special Issue Editor

Dr. Xiaoyu Hao

E-Mail Website
Guest Editor
Department of Pharmaceutical Science, College of Pharmacy, University of Nebraska Medical Center, 986125 Nebraska Medical Center, Omaha, NE 68198-6125, USA
Interests: ketene; epoxide; diazocompound; cycloaddition reaction; cascade reaction; autocatalysis; asymmetric catalysis; anion-π cataylsis; supramolecular catalysis; ClpXP activators; neurolysin inhibitors

Special Issue Information

Dear Colleagues,

Heterocyclic molecues continue to exhibit new chemistries due to their unique reactivity and their central roles in biological chemistry. This Special Issue will cover the most recent discovers in the synthesis and applications of heterocyclic molecues utilizing different strategies and methodologies, as well as aspects of medicinal chemistry incorporating these heterocyclic compounds. It is devoted to presenting and disseminating the most recent developments in this area.

Dr. Xiaoyu Hao
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Organics is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • heterocyclic compounds
  • organic synthesis
  • natural products
  • ring cyclizations
  • ring openings
  • rearrangement
  • green chemistry
  • biological activity

Published Papers (1 paper)

Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Review

21 pages, 4556 KiB  
Review
Synthesis of Antifungal Heterocycle-Containing Mannich Bases: A Comprehensive Review
by Diego Quiroga and Ericsson Coy-Barrera
Organics 2023, 4(4), 503-523; https://doi.org/10.3390/org4040035 - 09 Nov 2023
Viewed by 1259
Abstract
Mannich bases are a class of organic compounds usually obtained by the condensation reaction between an amine, a compound with active hydrogens, and an aldehyde. They are versatile intermediates in organic synthesis, and those compounds containing this motif find applications in pharmaceutical, agrochemical, [...] Read more.
Mannich bases are a class of organic compounds usually obtained by the condensation reaction between an amine, a compound with active hydrogens, and an aldehyde. They are versatile intermediates in organic synthesis, and those compounds containing this motif find applications in pharmaceutical, agrochemical, and even material fields since they are widely known for their wide range of biological activities, including antimicrobial properties. Thus, as part of our interest in antifungal agents, this narrative review aimed to gather information from the literature on the synthesis of various representative Mannich-base-containing compounds, particularly centered on those exhibiting antifungal properties. In this context, the compilation indicated that Mannich bases could be considered as a relevant toxophore/pharmacophore by incorporating heterocyclic moieties to be implemented for the design of new antifungal agents, given its proven efficacy against phytopathogens, other opportunistic human pathogens, and some dermatophytic fungal species, which can be further exploited as agrochemical agents or in medicinal applications to treat fungal infections. The antifungal effect exhibited by Mannich bases conjugated with oxa and/or aza-heterocycles suggests that compounds that have a heterocyclic system attached to the β-amino core are attractive alternatives oriented to the synthesis of novel and helpful antifungal agents. Full article
(This article belongs to the Special Issue Heterocyclic Compounds and Their Derivatives: Synthesis and Applications)
►▼ Show Figures

Scheme 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-1
Back to TopTop