Dear Colleagues,

It is well acknowledged that advances in science and technology have transformed our understanding of RNA biology and regulation. The human transcriptome is comprised mostly of noncoding RNAs (ncRNAs). The ncRNAs are involved in the orchestrated regulation of several cellular functions, and dysregulation in their interactions and/or expression may have consequences. These discoveries subverted the earlier notion “ncRNAs are the dark matter of DNA” and revealed the importance of ncRNAs in health and disease processes. NcRNAs are identified as critical regulators of the immune responses and immune system, particularly through the transcriptional and/or post-transcriptional modulation of immune-related genes. In recent years, ncRNAs have also been found in extracellular fluids and vesicles, known to mediate cell-to-cell communication, and may serve as disease-specific diagnostic, prognostic, and predictive biomarkers. Thus, a profound understanding of the regulation ncRNAs is essential for postulating candidate targets and therapeutic strategies to recuperate the immune responses.

In this Special Issue, we invite the submission of articles accentuating on the functional and regulatory role of ncRNAs such as long noncoding RNAs, microRNAs, and circular RNAs as immunomodulatory agents. This will contribute to an extensive assessment regarding their role in several immune-mediated diseases and highlight the potential use of ncRNAs as biomarkers as well as novel targets for the development of new immunomodulatory therapies and strategies.

Dr. Roopa Biswas
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Non-Coding RNA is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• non-coding RNA
• RNA biology
• microRNA
• lncRNA
• circular RNA
• epigenetics
• biomarkers
• inflammation
• exosomes
• immune responses
• immunomodulatory therapies