Special Issue "Current Strategies to Investigate the Role of ncRNAs in Carcinogenesis"
A special issue of Non-Coding RNA (ISSN 2311-553X).
Deadline for manuscript submissions: 31 December 2023 | Viewed by 5067
Carcinogenesis is a multistep process in which normal cells acquire genetic and epigenetic alterations that drive the onset of “hallmarks” of cancer, finally resulting in the development and progression of malignancies. Recent discoveries of the role of non-coding RNAs (ncRNAs) in these malignancies are a promising frontier of cancer genomics. ncRNAs can affect cancer cell fate and survival through a variety of different mechanisms, including transcriptional and post-transcriptional modification, chromatin remodeling, and signal transduction. However, to date, the exact function and mechanism of action of most of them is still unknown. As far as we know, ncRNAs create a complex network of mutual interactions and act as oncogenes or tumor suppressors. The understanding of the role of ncRNAs in tumorigenesis is a challenging goal in current biology.
Recently, profiling and next-generation sequencing (NGS) of ncRNAs have disclosed deep deregulation in human cancers, mostly due to aberrant mechanisms of ncRNAs biogenesis, such as amplification, deletion, abnormal epigenetic or transcriptional regulation. Additionally, the development of new bioinformatic tools has provided a unique opportunity to study transcriptome-wide ncRNA functions in carcinogenesis.
The aim of this Special Issue is to compile currently available computational and experimental strategies to investigate ncRNAs in cancer. We hope that this compendium will provide critical insights into the relevance of ncRNAs in cancer biology.
Dr. Deepak Sharma
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Non-Coding RNA is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- next-generation sequencing (NGS)
- cancer biology
- ncRNA in cancer