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Nanomaterials
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Nanotoxicology and Environmental Safety
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Nanotoxicology and Environmental Safety

A special issue of Nanomaterials (ISSN 2079-4991).

Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 3050

Special Issue Editors

Dr. Man Qu

E-Mail Website
Guest Editor
School of Nursing & School of Public Health, Yangzhou University, Yangzhou 225000, China
Interests: nanotoxicology and nanosafety; environmental toxicology
Special Issues, Collections and Topics in MDPI journals
Dr. Lu Kong

E-Mail Website
Guest Editor
School of Public Health, Southeast University, Nanjing 210000, China
Interests: reproductive toxicity based on nanomaterials

Special Issue Information

Dear Colleagues,

Nanomaterials are defined as materials with one or more dimensions of less than 100 nm, and have promise to bring advances in numerous fields. With the rapid development and wide application of nanomaterials, their potential toxicity to humans and environmental organisms is receiving great attention. Although numerous animal models (mice, rats, zebrafish, Caenorhabditis elegans, etc.) and cell-line-based simulations have recently been used for evaluating the toxicity of nanomaterials and exploring the mechanisms of this toxicity, much remains unclear regarding the mechanisms of nanotoxicity. Hence, it is necessary to develop a deeper understanding the situation and determine possible solutions.

The present Special Issue aims to bring together the latest advances in nanotoxicology and environmental safety. Our Special Issue has important predictive potential for our understanding of the possible biological effects, behavior, and underlying mechanisms of environmental toxicants or stresses in mammals and humans.

This Special Issue will welcome the following topics:

  • Environmental toxicology and safety of emerging nanomaterials;
  • Physiological, cellular and/or molecular mechanisms of nanomaterials’ toxicity;
  • Toxicity assessment and screening of low-toxic or non-toxic nanomaterials;
  • Transportation and distribution in vivo (fluorescent labeling, radioisotope labeling, etc.);
  • Pharmacological strategies and toxicity prevention of nanomaterials;
  • Reproductive toxicity and its underlying molecular mechanisms;
  • Ecotoxicological evaluation and model animal toxicology (both vertebrates and invertebrates).

Dr. Man Qu
Dr. Lu Kong
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • emerging nanomaterials
  • molecular mechanisms
  • screening of low-toxic or non-toxic nanomaterials
  • transportation and distribution in vivo
  • pharmacological strategies and prevention
  • reproductive toxicity and mechanisms
  • nanotoxicology based on model animals

Published Papers (2 papers)

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Research

14 pages, 15431 KiB  
Article
Polystyrene Nanoplastics Induce Lung Injury via Activating Oxidative Stress: Molecular Insights from Bioinformatics Analysis
by Tianyi Zhang, Sheng Yang, Yiling Ge, Xin Wan, Yuxin Zhu, Jie Li, Lihong Yin, Yuepu Pu and Geyu Liang
Nanomaterials 2022, 12(19), 3507; https://doi.org/10.3390/nano12193507 - 07 Oct 2022
Cited by 10 | Viewed by 2034
Abstract
(1) Background: Increasing evidence reveals that airborne plastic particles will continue to degrade into nanoplastics which are then inhaled by humans, causing injury to the respiratory system with controversial molecular mechanisms. (2) Methods: We used polystyrene nanoplastics (PS-NPs) as the representative pollutants to [...] Read more.
(1) Background: Increasing evidence reveals that airborne plastic particles will continue to degrade into nanoplastics which are then inhaled by humans, causing injury to the respiratory system with controversial molecular mechanisms. (2) Methods: We used polystyrene nanoplastics (PS-NPs) as the representative pollutants to explore the inhalation toxicology of nanoplastics and identified the potential mechanism through high-throughput sequencing. (3) Results: PS-NPs inhibited cell viability in a dose-dependent manner and 0 μg/cm2, 7.5 μg/cm2 and 30 μg/cm2 PS-NP-treated groups were selected for RNA-seq. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis suggested that lung injuries caused by PS-NPs were mediated via redox imbalance, which was verified by reactive oxygen species (ROS) staining. Additionally, we obtained ten key transcription factors (TFs) governing differentially expressed genes (DEGs), nine of which were involved in the regulation of oxidative stress. An oxidative stress-associated TF-mRNA regulatory network was constructed on account of the findings above. Further joint analysis with animal experiment data from the GEO database identified a crucial oxidative stress-related molecule, TNFRSF12A. qRT-PCR was performed to confirm the results of RNA-seq. (4) Conclusions: Our study indicates the potential role of oxidative stress in the mechanism of nanoplastics-induced lung injuries, with several key genes being promising targets to analyze in future investigations. Full article
(This article belongs to the Special Issue Nanotoxicology and Environmental Safety)
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10 pages, 2400 KiB  
Article
Bio-Fabrication of Bio-Inspired Silica Nanomaterials from Orange Peels in Combating Oxidative Stress
by Mosleh Mohammad Abomughaid
Nanomaterials 2022, 12(18), 3236; https://doi.org/10.3390/nano12183236 - 18 Sep 2022
Cited by 5 | Viewed by 1537
Abstract
Silica nanoparticles were synthesized using the aqueous extract of orange peels by the green chemistry approach and simple method. The physicochemical properties such as optical and chemical banding of as-synthesized silica nanoparticles were analyzed with UV–visible spectroscopy and Fourier transform infrared spectroscopy. Scanning [...] Read more.
Silica nanoparticles were synthesized using the aqueous extract of orange peels by the green chemistry approach and simple method. The physicochemical properties such as optical and chemical banding of as-synthesized silica nanoparticles were analyzed with UV–visible spectroscopy and Fourier transform infrared spectroscopy. Scanning Electron Microscopy with Energy Dispersive X-Ray Analysis and X-ray diffraction analysis were employed to confirm the shape, size and elemental purities of the silica nanoparticles. The thermal stability and mass loss of the silica nanoparticles was examined using thermogravimetric analysis and zeta potential analysis. The surface plasmon resonance band of the silica nanoparticle was obtained in the wavelength of 292 nm. Silica nanoparticles with a spherical and amorphous nature and an average size of 20 nm were produced and confirmed by X-ray diffraction and Scanning Electron Microscopy. The zeta potential of the silica nanoparticles was −25.00 mV. The strong and broad bands were located at 457, 642 and 796 cm−1 in the Fourier transform infrared spectra of the silica nanoparticles, associated with the Si–O bond. All the results of the present investigation confirmed and proved that the green synthesized silica nanoparticles were highly stable, pure and spherical in nature. In addition, the antioxidant activity of the green synthesized orange peel extract mediated by the silica nanoparticles was investigated with a DPPH assay. The antioxidant assay revealed that the synthesized silica nanoparticles had good antioxidant activity. In the future, green synthesized silica nanoparticles may be used for the production of nano-medicine. Full article
(This article belongs to the Special Issue Nanotoxicology and Environmental Safety)
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