Special Issue "Nitric Oxide Donors for Biomedical Applications: A Themed Issue Dedicated to Professor Alberto Gasco"
Deadline for manuscript submissions: closed (31 August 2022) | Viewed by 28452
Interests: nitric oxide; drug design; multi-target drugs; cancer multidrug resistance
Interests: nanoparticles; nitric oxide; cancer multidrug resistance; anticancer drugs
Interests: NO-donor; prodrug strategy; molecular hybrid design; drug design; drug delivery; drug targeting
Special Issues, Collections and Topics in MDPI journals
Molecules is pleased to announce a Special Issue dedicated to Professor Alberto Gasco of the University of Turin, Italy, for his outstanding contributions to research on nitric oxide (NO)-donors.
NO is a ubiquitous and pleiotropic messenger that is involved in many physiological and pathophysiological processes in nearly every organ system. It is a free radical with protective and regulatory functions in the cardiovascular and central/peripheral nervous systems. NO also plays a key role in innate immunity and inflammation since it is a necessary component of nonspecific defence mechanisms for several pathogens, including bacteria, viruses, parasites and fungi.
The difficulties inherent in handling NO, due to its gaseous nature and reactivity, have led to the development of a number of NO donors, namely, compounds that can release NO under physiological conditions. NO donors have shown broad therapeutic potential against cardiovascular pathologies, tumours, bacterial and microbial infections, and in the maintenance of homeostasis in gastrointestinal and respiratory tracts. In recent years, the combination of NO donors and cytotoxic agents has also been proposed as a valid strategy for reversing the multidrug resistance (MDR) that is often encountered in conventional anticancer therapies.
Since the biological effects of NO are strictly dependent on its concentration, NO delivery should be controlled with great accuracy, in terms of space, time and dosage. Light-triggered NO donors and suitable nanosystems have recently been developed for regulated spatiotemporal release and are promising new therapeutic devices. In fact, light and nanocarriers are the most finely tuneable approach for the non-invasive delivery of NO to the desired biological environments.
This Special Issue is dedicated to Professor Alberto Gasco for his research on NO-donor pro-drugs, and, specifically, the 1,2,5-oxadiazole 2-oxide (furoxan) system. His work in this field has led to pioneering studies, beginning in the early 1990s, on the design of NO donors and NO-donor hybrid molecules and on their physico-chemical and biological profile. Of great importance is his research in the field of multitarget-drug design that he performed with passionate dedication, in collaboration with scientists of international renown, until very recently. His studies on cardiovascular, non-steroidal anti-inflammatory agents and, more recently, antitumor drugs are particularly worthy of attention. These studies have led to numerous publications in prestigious international journals and several patents in collaboration with companies in the pharmaceutical sector.
As Guest Editors, we aim to collect both original papers and up-to-date reviews that focus on the design, synthesis and biological effects of new and previously described NO donors. We encourage researchers working in this area to contribute to “Nitric Oxide Donors for Biomedical Applications: A Themed Issue Dedicated to Professor Alberto Gasco”.
Prof. Dr. Roberta Fruttero
Dr. Elena Gazzano
Dr. Federica Sodano
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Nitric oxide
- NO donors
- NO photodonors
- Controlled release systems
- Biomedical applications
- Antimicrobial activity
- Anticancer activity