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Molecules
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Nanostructured Materials: Synthesis, Functionalization and Applications in Biomedicine
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Nanostructured Materials: Synthesis, Functionalization and Applications in Biomedicine

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Nanochemistry".

Deadline for manuscript submissions: 15 May 2024 | Viewed by 8064

Special Issue Editors

Prof. Dr. Ying-Jie Zhu

E-Mail Website1 Website2
Guest Editor
Biomaterials and Tissue Engineering Research Center, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China
Interests: nanostructured materials; biomaterials; drug delivery; bone defect repair; skin wound healing; bioimaging; anti-tumor
Dr. Heng Li

E-Mail Website
Guest Editor
Biomaterials and Tissue Engineering Research Center, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China
Interests: hydroxyapatite; nanowires; biocompatible electronic devices; battery

Special Issue Information

Dear Colleagues,

Nanostructured materials are a class of materials whose constituting building units have sizes ranging from 1 to 100 nm in one, two or three dimensions. Over the past several decades, nanostructured materials have drawn extensive attention worldwide due to their unique and attractive properties. The high surface-to-volume ratio, ability for surface functionalization, and other superior properties of nanostructured materials provide promising applications in a variety of fields including nanomedicine. As a result, nanostructured materials have become a popular and rapidly evolving research field, and have demonstrated promising potential in solving various biomedical problems that cannot be addressed via traditional techniques. Various types of inorganic and organic nanostructured materials—including quantum dots, nanoparticles, nanospheres, nanorods, nanowires, nanotubes, nanosheets, mesoporous materials, and nanocomposites—have been synthesized and investigated for applications in various biomedical fields, such as drug delivery, bone defect repair, orthopedic surgery, tooth repair, skin wound healing, tissue engineering, regenerative medicine, anti-tumor therapy, biosensing, bioimaging, diagnosis and therapy.

This Special Issue on “Nanostructured Materials: Synthesis, Functionalization and Applications in Biomedicine” aims to gather original interdisciplinary research on the recent progress in nanostructured materials for biomedical applications. This Special Issue focuses on all aspects of research regarding the design strategy, synthesis, characterization, functionalization and biomedical applications of nanostructured materials. It is our great pleasure to invite researchers in the relevant fields to contribute original research manuscripts, including full research papers, short communications, and reviews within the scope of this Special Issue.

Prof. Dr. Ying-Jie Zhu
Dr. Heng Li
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanostructured materials
  • biomaterials
  • dental materials
  • biomedicine
  • biomedical applications
  • drug delivery
  • bone defect repair
  • orthopedic surgery
  • skin wound healing
  • anti-tumor
  • biosensing
  • bioimaging
  • diagnosis
  • therapy

Published Papers (4 papers)

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Research

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18 pages, 6130 KiB  
Article
A Rapid Self−Assembling Peptide Hydrogel for Delivery of TFF3 to Promote Gastric Mucosal Injury Repair
by Jialei Chen, Jing Luo, Di Su, Na Lu, Jiawei Zhao and Zhongli Luo
Molecules 2024, 29(9), 1944; https://doi.org/10.3390/molecules29091944 - 24 Apr 2024
Viewed by 254
Abstract
Self-assembled peptide-based nanobiomaterials exhibit promising prospects for drug delivery applications owing to their commendable biocompatibility and biodegradability, facile tissue uptake and utilization, and minimal or negligible unexpected toxicity. TFF3 is an active peptide autonomously secreted by gastric mucosal cells, possessing multiple biological functions. [...] Read more.
Self-assembled peptide-based nanobiomaterials exhibit promising prospects for drug delivery applications owing to their commendable biocompatibility and biodegradability, facile tissue uptake and utilization, and minimal or negligible unexpected toxicity. TFF3 is an active peptide autonomously secreted by gastric mucosal cells, possessing multiple biological functions. It acts on the surface of the gastric mucosa, facilitating the repair process of gastric mucosal damage. However, when used as a drug, TFF3 faces significant challenges, including short retention time in the gastric mucosal cavity and deactivation due to degradation by stomach acid. In response to this challenge, we developed a self−assembled short peptide hydrogel, Rqdl10, designed as a delivery vehicle for TFF3. Our investigation encompasses an assessment of its properties, biocompatibility, controlled release of TFF3, and the mechanism underlying the promotion of gastric mucosal injury repair. Congo red/aniline blue staining revealed that Rqdl10 promptly self-assembled in PBS, forming hydrogels. Circular dichroism spectra indicated the presence of a stable β-sheet secondary structure in the Rqdl10 hydrogel. Cryo-scanning electron microscopy and atomic force microscopy observations demonstrated that the Rqdl10 formed vesicle-like structures in the PBS, which were interconnected to construct a three-dimensional nanostructure. Moreover, the Rqdl10 hydrogel exhibited outstanding biocompatibility and could sustainably and slowly release TFF3. The utilization of the Rqdl10 hydrogel as a carrier for TFF3 substantially augmented its proliferative and migratory capabilities, while concurrently bolstering its anti-inflammatory and anti-apoptotic attributes following gastric mucosal injury. Our findings underscore the immense potential of the self-assembled peptide hydrogel Rqdl10 for biomedical applications, promising significant contributions to healthcare science. Full article
(This article belongs to the Special Issue Nanostructured Materials: Synthesis, Functionalization and Applications in Biomedicine)
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19 pages, 6964 KiB  
Article
Synergistic Effects of AgNPs and Biochar: A Potential Combination for Combating Lung Cancer and Pathogenic Bacteria
by Maha N. Abu Hajleh, Muhamad Al-limoun, Amjad Al-Tarawneh, Tahani J. Hijazin, Moath Alqaraleh, Khaled Khleifat, Osama Y. Al-Madanat, Yaseen Al Qaisi, Ahmad AlSarayreh, Ali Al-Samydai, Haitham Qaralleh and Emad A. S. Al-Dujaili
Molecules 2023, 28(12), 4757; https://doi.org/10.3390/molecules28124757 - 14 Jun 2023
Cited by 3 | Viewed by 1493
Abstract
The synthesis of reliable biological nanomaterials is a crucial area of study in nanotechnology. In this study, Emericella dentata was employed for the biosynthesis of AgNPs, which were then combined with synthesized biochar, a porous structure created through biomass pyrolysis. The synergistic effects [...] Read more.
The synthesis of reliable biological nanomaterials is a crucial area of study in nanotechnology. In this study, Emericella dentata was employed for the biosynthesis of AgNPs, which were then combined with synthesized biochar, a porous structure created through biomass pyrolysis. The synergistic effects of AgNPs and biochar were evaluated through the assessment of pro-inflammatory cytokines, anti-apoptotic gene expression, and antibacterial activity. Solid biosynthesized AgNPs were evaluated by XRD and SEM, with SEM images revealing that most of the AgNPs ranged from 10 to 80 nm, with over 70% being less than 40 nm. FTIR analysis indicated the presence of stabilizing and reducing functional groups in the AgNPs. The nanoemulsion’s zeta potential, hydrodynamic diameter, and particle distribution index were found to be −19.6 mV, 37.62 nm, and 0.231, respectively. Biochar, on the other hand, did not have any antibacterial effects on the tested bacterial species. However, when combined with AgNPs, its antibacterial efficacy against all bacterial species was significantly enhanced. Furthermore, the combined material significantly reduced the expression of anti-apoptotic genes and pro-inflammatory cytokines compared to individual treatments. This study suggests that low-dose AgNPs coupled with biochar could be a more effective method to combat lung cancer epithelial cells and pathogenic bacteria compared to either substance alone. Full article
(This article belongs to the Special Issue Nanostructured Materials: Synthesis, Functionalization and Applications in Biomedicine)
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Review

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23 pages, 7526 KiB  
Review
Calcium Phosphate-Based Nanomaterials: Preparation, Multifunction, and Application for Bone Tissue Engineering
by Xin Chen, Huizhang Li, Yinhua Ma and Yingying Jiang
Molecules 2023, 28(12), 4790; https://doi.org/10.3390/molecules28124790 - 15 Jun 2023
Cited by 12 | Viewed by 2657
Abstract
Calcium phosphate is the main inorganic component of bone. Calcium phosphate-based biomaterials have demonstrated great potential in bone tissue engineering due to their superior biocompatibility, pH-responsive degradability, excellent osteoinductivity, and similar components to bone. Calcium phosphate nanomaterials have gained more and more attention [...] Read more.
Calcium phosphate is the main inorganic component of bone. Calcium phosphate-based biomaterials have demonstrated great potential in bone tissue engineering due to their superior biocompatibility, pH-responsive degradability, excellent osteoinductivity, and similar components to bone. Calcium phosphate nanomaterials have gained more and more attention for their enhanced bioactivity and better integration with host tissues. Additionally, they can also be easily functionalized with metal ions, bioactive molecules/proteins, as well as therapeutic drugs; thus, calcium phosphate-based biomaterials have been widely used in many other fields, such as drug delivery, cancer therapy, and as nanoprobes in bioimaging. Thus, the preparation methods of calcium phosphate nanomaterials were systematically reviewed, and the multifunction strategies of calcium phosphate-based biomaterials have also been comprehensively summarized. Finally, the applications and perspectives of functionalized calcium phosphate biomaterials in bone tissue engineering, including bone defect repair, bone regeneration, and drug delivery, were illustrated and discussed by presenting typical examples. Full article
(This article belongs to the Special Issue Nanostructured Materials: Synthesis, Functionalization and Applications in Biomedicine)
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24 pages, 5834 KiB  
Review
Cell Membrane Biomimetic Nanoparticles with Potential in Treatment of Alzheimer’s Disease
by Xinyu Zhong, Yue Na, Shun Yin, Chang Yan, Jinlian Gu, Ning Zhang and Fang Geng
Molecules 2023, 28(5), 2336; https://doi.org/10.3390/molecules28052336 - 03 Mar 2023
Cited by 9 | Viewed by 2880
Abstract
Alzheimer’s disease (AD) is to blame for about 60% of dementia cases worldwide. The blood–brain barrier (BBB) prevents many medications for AD from having clinical therapeutic effects that can be used to treat the affected area. Many researchers have turned their attention to [...] Read more.
Alzheimer’s disease (AD) is to blame for about 60% of dementia cases worldwide. The blood–brain barrier (BBB) prevents many medications for AD from having clinical therapeutic effects that can be used to treat the affected area. Many researchers have turned their attention to cell membrane biomimetic nanoparticles (NPs) to solve this situation. Among them, NPs can extend the half-life of drugs in the body as the “core” of the wrapped drug, and the cell membrane acts as the “shell” of the wrapped NPs to functionalize the NPs, which can further improve the delivery efficiency of nano-drug delivery systems. Researchers are learning that cell membrane biomimetic NPs can circumvent the BBB’s restriction, prevent harm to the body’s immune system, extend the period that NPs spend in circulation, and have good biocompatibility and cytotoxicity, which increases efficacy of drug release. This review summarized the detailed production process and features of core NPs and further introduced the extraction methods of cell membrane and fusion methods of cell membrane biomimetic NPs. In addition, the targeting peptides for modifying biomimetic NPs to target the BBB to demonstrate the broad prospects of cell membrane biomimetic NPs drug delivery systems were summarized. Full article
(This article belongs to the Special Issue Nanostructured Materials: Synthesis, Functionalization and Applications in Biomedicine)
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