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Topical Advisory Panel Members' Collection Series: Synthesis of Natural Compounds and Derivatives with Biological Activity

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".

Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 2605

Special Issue Editors


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Guest Editor
DeFENS, Department of Food, Environmental and Nutritional Sciences, Università degli Studi di Milano, Via Celoria 2, 20133 Milano, Italy
Interests: transition metal catalyzed reactions; synthetic methodologies to obtain bioactive molecules
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Laboratoire Synthèse et Isolement de Molécules Bioactives (SIMBA, EA 7502), Université de Tours, Faculté de Pharmacie, Parc de Grandmont, 31 Avenue Monge, 37200 Tours, France
Interests: methodology in organic synthesis; catalysis by copper complexes; palladocatalysed reactions; heterocycles; medicinal chemistry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to announce our forthcoming Special Issue, entitled “Topical Advisory Panel Members' Collection Series: Synthesis of Natural Compounds and Derivatives with Biological Activity”. This collection will be assembled from the papers of researchers invited by the Topical Advisory Panel Members.

The contributions of other authors will also be considered, but this Special Issue focuses primarily on highlighting recent interesting investigations conducted in the laboratories of our section’s Topical Advisory Panel Members. This will allow us to provide an attractive open access publishing platform for organic chemistry and medicinal chemistry research data.

Dr. Michail Christodoulou
Dr. Julien Petrignet
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • small natural molecules
  • bio-inspired compounds
  • biological activities
  • anticancer
  • anti-infectious

Published Papers (2 papers)

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Research

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11 pages, 2481 KiB  
Article
Targeting Ovarian Cancer with Chalcone Derivatives: Cytotoxicity and Apoptosis Induction in HGSOC Cells
by Elif Merve Aydin, İdil Su Canıtez, Eleonora Colombo, Salvatore Princiotto, Daniele Passarella, Sabrina Dallavalle, Michael S. Christodoulou and Irem Durmaz Şahin
Molecules 2023, 28(23), 7777; https://doi.org/10.3390/molecules28237777 - 25 Nov 2023
Viewed by 833
Abstract
Ovarian cancer ranks as the eighth most prevalent form of cancer in women across the globe and stands as the third most frequent gynecological cancer, following cervical and endometrial cancers. Given its resistance to standard chemotherapy and high recurrence rates, there is an [...] Read more.
Ovarian cancer ranks as the eighth most prevalent form of cancer in women across the globe and stands as the third most frequent gynecological cancer, following cervical and endometrial cancers. Given its resistance to standard chemotherapy and high recurrence rates, there is an urgent imperative to discover novel compounds with potential as chemotherapeutic agents for treating ovarian cancer. Chalcones exhibit a wide array of biological properties, with a particular focus on their anti-cancer activities. In this research, we documented the synthesis and in vitro study of a small library of chalcone derivatives designed for use against high-grade serous ovarian cancer (HGSOC) cell lines, specifically OVCAR-3, OVSAHO, and KURAMOCHI. Our findings revealed that three of these compounds exhibited cytotoxic and anti-proliferative effects against all the tested HGSOC cell lines, achieving IC50 concentrations lower than 25 µM. Further investigations disclosed that these chalcones prompted an increase in the subG1 phase cell cycle and induced apoptosis in OVCAR-3 cells. In summary, our study underscores the potential of chalcones as promising agents for the treatment of ovarian cancer. Full article
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Review

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21 pages, 1956 KiB  
Review
Fungal Biotransformation of Hazardous Organic Compounds in Wood Waste
by Magdalena Komorowicz, Dominika Janiszewska-Latterini, Anna Przybylska-Balcerek and Kinga Stuper-Szablewska
Molecules 2023, 28(12), 4823; https://doi.org/10.3390/molecules28124823 - 17 Jun 2023
Cited by 2 | Viewed by 1409
Abstract
A diverse spectrum of organisms, such as fungi, bacteria, and actinomycetes, can degrade and transform organic matter, including wood, into valuable nutrients. A sustainable economy has the goal of efficiently using waste as raw materials, and in this optic, it uses biological preparations [...] Read more.
A diverse spectrum of organisms, such as fungi, bacteria, and actinomycetes, can degrade and transform organic matter, including wood, into valuable nutrients. A sustainable economy has the goal of efficiently using waste as raw materials, and in this optic, it uses biological preparations more and more often, supporting the decomposition of lignocellulosic waste. With reference to wood wastes, which are produced in a substantial amount by the forest and wood industry, one of the possibilities to biodegrade such lignocellulosic material is the composting process. In particular, microbiological inoculum containing dedicated fungi can contribute to the biodegradation of wood waste, as well as the biotransformation of substances from the protection of wood, such as pentachlorophenol (PCP), lindane (hexachlorobenzene) and polycyclic aromatic hydrocarbons (PAHs). The purpose of this research was to produce a literature review in terms of the selection of decay fungi that could potentially be used in toxic biotransformation unions. The findings of the literature review highlighted how fungi such as Bjerkandera adusta, Phanerochaete chrysosporium, and Trametes versicolor might be ingredients of biological consortia that can be effectively applied in composting wood waste containing substances such as pentachlorophenol, lindane, and polycyclic aromatic hydrocarbons (PAHs). Full article
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