Telomere and Subtelomeric Chromatin Structure and Organization in Yeasts and Filamentous Fungi
A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Molecular Microbiology and Immunology".
Deadline for manuscript submissions: closed (31 May 2021) | Viewed by 6303
Special Issue Editor
Interests: telomeres; chromatin; recombination
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The ends of eukaryotic chromosomes, or telomeres, are essential for chromosomal replication and protection against DNA damage and genome instability. The loss of the telomeric sequence leads to senescence and cell death through multiple rounds of replication. This loss is compensated by the ribonucleoprotein telomerase that uses its RNA component as a template for the addition of guanine and thymine-rich (G+T-rich) DNA sequences of telomeres. This G+T-rich DNA is packaged with specific proteins that maintain the telomere and confers its protective properties against genome instability. In yeast, the telomere chromatin structure is unique from the nucleosomal packaging in the genome. As a protein complex, the stability of the chromatin is dependent on the affinities of proteins for binding to one another and binding to telomeric DNA. Defects in components of this structure are manifested in differing lengths of the telomeric DNA and the stability of the telosome as assayed in vitro. How the structural components of telomere chromatin are integrated into a packaged unit is poorly understood.
Subtelomeric regions in yeast and fungi are often, but not exclusively, heterochromatic areas that are often responsible for telomere-initiation epigenetic silencing of gene activity (telomere position effect). Although the organization of subtelomeric regions is well understood in Saccharomyces cerevisiae, the organization and nucleosome structure appear to differ among different classes of fungi.
The aim of this Special Issue of Microorganisms is to present a collection of articles that reflect the current state of our understanding of fungal telomere chromatin structure and subtelomeric organization and structure. Manuscripts covering all aspects of research relating to this topic are welcome, from different fungal systems (both reviews are original research) are encouraged.
Prof. Arthur J. Lustig
Guest Editor
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Keywords
- Telomeres
- subtelomeres
- heterochromatin
- yeasts
- fungi
- chromatin
