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Microorganisms
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Selected Papers from the Microbiome R&D and Business Collaboration Congress:...
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Selected Papers from the Microbiome R&D and Business Collaboration Congress: Asia

A special issue of Microorganisms (ISSN 2076-2607).

Deadline for manuscript submissions: closed (31 December 2020) | Viewed by 10318

Special Issue Editor

Prof. Dr. Eric (Chun-Ming) Huang

E-Mail Website1 Website2
Guest Editor
Department of Biomedical Sciences and Engineering, National Central University, Taoyuan 32001, Taiwan
Interests: skin microbiome; acne vaccine; beneficial microbes
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

A microbiome is the totality of microbes, their genetic elements (genomes), and environmental interactions in a defined environment.  In this Special Issue, we call for manuscripts with research at microbiomes which includes (1) mechanisms underlying the interaction between microbes and humans/plants/environments; (2) new technology of analyzing microbiomes; (3) biomarkers identified from the microbiome; and (4) medicines, diagnostics, or products derived from microbiome. Other fields such as artificial intelligence (AI) applied for microbiome research are also welcome.

This Special Issue is the outcome of papers submitted to the Microbiome R&D and Business Collaboration Congress: Asia (http://www.global-engage.com/event/microbiome-asia/) held in Tawan, organized by the National Central University and National Chiao Tung University (GLORIA) of Taiwan.

Prof. Dr. Eric (Chun-Ming) Huang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (2 papers)

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Research

12 pages, 1489 KiB  
Article
Mouse Abdominal Fat Depots Reduced by Butyric Acid-Producing Leuconostoc mesenteroides
by John Jackson Yang, Minh Tan Pham, Adelia Riezka Rahim, Tsung-Hsien Chuang, Ming-Fa Hsieh and Chun-Ming Huang
Microorganisms 2020, 8(8), 1180; https://doi.org/10.3390/microorganisms8081180 - 3 Aug 2020
Cited by 8 | Viewed by 3449
Abstract
The activation of peroxisome proliferator-activated rece ptor gamma (PPAR-γ) is known to induce the differentiation of adipocytes. This study aimed to investigate the probiotic effect of Leuconostoc mesenteroides (L. mesenteroides) on high-fat diet (HFD)-induced PPAR-γ activation and abdominal fat depots. Incubation [...] Read more.
The activation of peroxisome proliferator-activated rece ptor gamma (PPAR-γ) is known to induce the differentiation of adipocytes. This study aimed to investigate the probiotic effect of Leuconostoc mesenteroides (L. mesenteroides) on high-fat diet (HFD)-induced PPAR-γ activation and abdominal fat depots. Incubation of differentiated 3T3-L1 adipocytes with media of L. mesenteroides EH-1, a butyric acid-producing strain, significantly reduced the amounts of lipid droplets. The oral administration of L. mesenteroides EH-1 produced large amounts (>1 mM) of butyric acid in cecum and attenuated the HFD-induced upregulation of PPAR-γ and accumulation of abdominal fats in mice. The combination of 2% glucose with L. mesenteroides EH-1 increased the production of butyric acid and potentiated the probiotic activity of L. mesenteroides EH-1 against the formation of lipid droplets in 3T3-L1 adipocytes as well as abdominal fats in HFD-fed mice. The inhibition of free fatty acid receptor 2 (Ffar2) by its antagonist, GLPG-0974, markedly diminished the probiotic effects of L. mesenteroides EH-1 plus glucose on the suppression of HFD-induced PPAR-γ and abdominal fats. Besides demonstrating the probiotic value of L. mesenteroides EH-1, our results highlight the possible therapy targeting the butyric acid-activated Ffar2 pathway to reduce abdominal fats. Full article
(This article belongs to the Special Issue Selected Papers from the Microbiome R&D and Business Collaboration Congress: Asia)
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15 pages, 4159 KiB  
Article
Lactobacillus salivarius Subspecies salicinius SA-03 is a New Probiotic Capable of Enhancing Exercise Performance and Decreasing Fatigue
by Mon-Chien Lee, Yi-Ju Hsu, Hsieh-Hsun Ho, Shih-Hung Hsieh, Yi-Wei Kuo, Hsin-Ching Sung and Chi-Chang Huang
Microorganisms 2020, 8(4), 545; https://doi.org/10.3390/microorganisms8040545 - 9 Apr 2020
Cited by 50 | Viewed by 6050
Abstract
Probiotics are increasingly being used as a nutritional supplement by athletes to improve exercise performance and reduce post-exercise fatigue. Lactobacillus salivarius is a natural flora in the gastrointestinal tract of humans and animals. Lactobacillus salivarius subspecies salicinius (SA-03) is an isolate from the [...] Read more.
Probiotics are increasingly being used as a nutritional supplement by athletes to improve exercise performance and reduce post-exercise fatigue. Lactobacillus salivarius is a natural flora in the gastrointestinal tract of humans and animals. Lactobacillus salivarius subspecies salicinius (SA-03) is an isolate from the 2008 Olympic women’s 48 kg weightlifting gold medalist’s gut microbiota. In this study, we investigated its beneficial effects on physical fitness. Male ICR mice were divided into four groups (n = 10 per group) and orally administered with SA-03 for 4 weeks at 0, 2.05 × 109, 4.10 × 109, or 1.03 × 1010 CFU/kg/day. Results showed that 4 weeks of SA-03 supplementation significantly improved muscle strength and endurance performance, increased hepatic and muscular glycogen storage, and decreased lactate, blood urea nitrogen (BUN), ammonia, and creatine kinase (CK) levels after exercise. These observations suggest that SA-03 could be used as a nutritional supplement to enhance exercise performance and reduce. Full article
(This article belongs to the Special Issue Selected Papers from the Microbiome R&D and Business Collaboration Congress: Asia)
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