Viral Oncogenesis in Humans
A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Virology".
Deadline for manuscript submissions: closed (30 June 2021) | Viewed by 8036
Special Issue Editor
Interests: bacterial infections; viral infections; cancer; oncomodulatory effects of microbial infections; multi-drug resistance; metabolism; virus isolation, identification and genetic characterization; evolution of human pathogens; phylogenetic analysis of pathogens
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The molecular mechanisms of oncogenesis are complex and can be activated in stem cells by virus-induced genetic and epigenetic changes that lead to alterations in cellular homeostasis and interference with physiological developmental programs. While it is estimated that viruses account for almost 20% of all human cancer cases, only some tumor types are currently associated with a viral etiology. Cervical and genital squamous cell carcinomas are associated, in 99.7% of cases, with oncogenic strains of HPV, hepatocellular carcinoma is associated with HBV and HCV infections in about 80% of cases, and EBV is detected in almost all Burkitt’s lymphomas from endemic areas. On the other hand, only a minority of HTLV1 carriers develop T-cell lymphoma, and moreover, Merkel cell carcinoma and Kaposi’s sarcoma seem to be associated with MCPyV and KSHV principally in immunodeficient subjects. Future tumor virology may be able to demonstrate the oncogenic potential of other common infections that might contribute to the global tumor burden. This may be the case for HCMV, detected in several types of common tumors, including glioblastomas and breast and colorectal carcinomas.
Malignancy induced by viruses is influenced by a combination of viral, host, and environmental factors that are currently not fully understood. This Special Issue aims at an improved understanding of these complex interactions. Research articles or review articles on the topic are welcome.
• Oncogenic viruses
• Cancer
• Epigenetics
• Virus-host interactions
• Viral carcinogenesis
Fabio Verginelli
Guest Editor
Manuscript Submission Information
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Keywords
- Oncogenic viruses; Cancer; Epigenetics; Virus-host interactions; Viral carcinogenesis
