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Microorganisms
Special Issues
Engineering Cyanophages and Cyanotoxins
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Engineering Cyanophages and Cyanotoxins

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Microbial Biotechnology".

Deadline for manuscript submissions: 31 July 2024 | Viewed by 1526

Special Issue Editor

Dr. Tao Sun

E-Mail Website
Guest Editor
Center for Biosafety Research and Strategy, Tianjin University, Tianjin, China
Interests: microbial synthetic biology; small RNAs-based biotechnology; microbial biomedicine

Special Issue Information

Dear Colleagues,

The excessive proliferation of harmful cyanobacteria produces various toxic secondary metabolites which pose a threat to aquatic ecosystems and human health. Cyanophages are a kind of virus that exclusively infect cyanobacteria, which is considered a potential strategy of dealing with cyanobacterial blooms. Nevertheless, the infecting host range and lysis efficiency of natural cyanophages are limited, eliciting the necessity of constructing non-natural cyanophages via synthetic biology to expand their host range and efficiency. Meanwhile, recent studies have demonstrated the biotechnological application of cyanotoxins, suggesting they may be hidden gems.

This Special Issue of Microorganisms will gather relevant papers that report on the recent advances in “Engineering Cyanophages and Cyanotoxins”, either in the form of original research or review papers (covering different aspects of interactions between cyanophages and host cyanobacteria; the assembly, modification, and resurrection of artificial cyanophages in the host; the biosynthesis and heterologous production of cyanotoxins; and the application prospects of artificial cyanophages and cyanotoxins).

Dr. Tao Sun
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • artificial phage/cyanophage genome
  • cyanotoxin
  • harmful algae

Published Papers (1 paper)

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Review

17 pages, 2633 KiB  
Review
Recent Advances in Cyanotoxin Synthesis and Applications: A Comprehensive Review
by Zipeng Li, Xiaofei Zhu, Zhengyu Wu, Tao Sun and Yindong Tong
Microorganisms 2023, 11(11), 2636; https://doi.org/10.3390/microorganisms11112636 - 26 Oct 2023
Cited by 1 | Viewed by 1374
Abstract
Over the past few decades, nearly 300 known cyanotoxins and more than 2000 cyanobacterial secondary metabolites have been reported from the environment. Traditional studies have focused on the toxic cyanotoxins produced by harmful cyanobacteria, which pose a risk to both human beings and [...] Read more.
Over the past few decades, nearly 300 known cyanotoxins and more than 2000 cyanobacterial secondary metabolites have been reported from the environment. Traditional studies have focused on the toxic cyanotoxins produced by harmful cyanobacteria, which pose a risk to both human beings and wildlife, causing acute and chronic poisoning, resulting in diarrhea, nerve paralysis, and proliferation of cancer cells. Actually, the biotechnological potential of cyanotoxins is underestimated, as increasing studies have demonstrated their roles as valuable products, including allelopathic agents, insecticides and biomedicines. To promote a comprehensive understanding of cyanotoxins, a critical review is in demand. This review aims to discuss the classifications; biosynthetic pathways, especially heterogenous production; and potential applications of cyanotoxins. In detail, we first discuss the representative cyanotoxins and their toxic effects, followed by an exploration of three representative biosynthetic pathways (non-ribosomal peptide synthetases, polyketide synthetases, and their combinations). In particular, advances toward the heterologous biosynthesis of cyanotoxins in vitro and in vivo are summarized and compared. Finally, we indicate the potential applications and solutions to bottlenecks for cyanotoxins. We believe that this review will promote a comprehensive understanding, synthetic biology studies, and potential applications of cyanotoxins in the future. Full article
(This article belongs to the Special Issue Engineering Cyanophages and Cyanotoxins)
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