Advances in the Research on Leptospira and Leptospirosis

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Parasitology".

Deadline for manuscript submissions: 15 July 2024 | Viewed by 947

Special Issue Editors


E-Mail Website
Guest Editor
Centro de Bacteriología, Instituto Adolfo Lutz, Sao Paulo 01246-902, SP, Brazil
Interests: leptospirosis; Leptospira

E-Mail Website
Guest Editor
Clinical Hospital, School of Medicine, University of São Paulo, São Paulo, Brazil
Interests: leptospirosis; Leptospira

Special Issue Information

Dear Colleagues,

Leptospirosis is a neglected and re-emerging disease with high morbidity and mortality in humans and animals and is one of the most widespread zoonotic diseases worldwide. Human infections occur through direct contact with the urine of infected animals, such as rodents, livestock, and domesticated pets, and exposure through water or soil. Increasing temperature and extreme weather events, due to global climate change, can prolong the survival of leptospires in the environment, expanding the geographical distribution of these bacteria. Clinical illness in humans can range from a mild, self-limiting acute febrile illness to a severe, life-threatening condition with multiple organ dysfunction. No effective human vaccine is currently available. The pathogenesis of severe leptospirosis is poorly understood, and studies should focus on identifying potential biomarkers for diagnostic and therapeutic targets and prognostic applications. This Special Issue solicits manuscripts on One Health approach, perspectives, challenges, pathology, clinical cases, vaccine development, genomics, and recent advances in the diagnostics of leptospirosis. We welcome both original research articles and comprehensive review papers.

Dr. Eliete Caló Romero
Dr. Antônio José Magaldi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • leptospirosis
  • zoonoses
  • environmental exposure
  • epidemiology
  • pathogenesis
  • clinical cases
  • diagnosis
  • genomics
  • serology
  • vaccine
  • One Health

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

11 pages, 4786 KiB  
Communication
Exploring Leptospira interrogans FDAARGOS_203: Insights into AMR and Anti-Phage Defense
by Pavlo Petakh, Valentyn Oksenych and Oleksandr Kamyshnyi
Microorganisms 2024, 12(3), 546; https://doi.org/10.3390/microorganisms12030546 - 08 Mar 2024
Cited by 1 | Viewed by 798
Abstract
Leptospira, which are known to be important disease-causing agents transmitted between animals and humans, result in significant illness and, in some cases, significant death in human populations. This purpose of this study was to examine the genomic structure of Leptospira interrogans serovar Copenhageni [...] Read more.
Leptospira, which are known to be important disease-causing agents transmitted between animals and humans, result in significant illness and, in some cases, significant death in human populations. This purpose of this study was to examine the genomic structure of Leptospira interrogans serovar Copenhageni strain FDAARGOS_203 to identify the specific genetic factors that contribute to antimicrobial resistance (AMR) and defense against phages. The genome, consisting of two contigs totaling 4,630,574 base pairs, underwent thorough examination for protein-coding sequences, transfer RNA genes, and ribosomal RNA genes. A total of twenty-two antibiotic resistance genes that specifically target essential cellular processes such as cell wall synthesis, DNA replication, and protein synthesis have been identified. Significant among these were gidB, gdpD, and ggsA, each involved in separate aspects of antibiotic resistance. In addition, the investigation explored the defense mechanisms of bacteriophages, revealing the presence of defense islands that contain a range of anti-phage systems, including RM_Type_IV, PrrC, Borvo, CAS_Class1-Subtype-IC, and CAS_Class1-Subtype-IB. This comprehensive genomic analysis enhances our understanding of the molecular mechanisms that determine Leptospira’s ability to adapt to various environments. The identified genetic factors linked to AMR and defense against phages not only enhance our scientific comprehension, but also provide a basis for focused interventions to reduce the impact of leptospirosis. Full article
(This article belongs to the Special Issue Advances in the Research on Leptospira and Leptospirosis)
Show Figures

Figure 1

Back to TopTop