Animal Viral Evolution

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Virology".

Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 2850

Special Issue Editors


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Guest Editor
Plum Island Animal Disease Center, Agriculture Research Service, USDA, Orient, NY 11944, USA
Interests: viral evolution; pathogenesis; vaccines

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Guest Editor
Veterinary Population Medicine Department, University of Minnesota College of Veterinary Medicine, St. Paul, MN 55108, USA
Interests: infectious diseases; epidemiology; veterinary medicine

Special Issue Information

Dear Colleagues,

Natural selection plays a critical role in shaping the evolutionary dynamics of DNA and RNA viral populations. Multiple mechanisms including positive and negative selection, recombination, selection relaxation, codon and dinucleotide usage among others represent some of the mechanisms promoting the adaptation of these populations. In this context, an understanding of the different evolutionary dynamic signatures of these populations is critical component to control viral diseases. Animal populations are subject to infection with a variety of viral agents. Currently, animal diseases such as African swine fever, classical swine fever, and foot and mouth disease, among others, represent a real threat to the worldwide economy. Zoonotic diseases can also have significant public health implications, as is seen in the case of influenza virus. With the ever-evolving evolution of viral agents within human populations, including the SARS-CoV-2 pandemic and Mpox virus outbreaks, there is a risk for zooanthroponotic transmission events in animal populations, promoting the potential adaptation of human pathogens in animal populations, a situation that might complicate the control of these pathogens.

In this special issue of Microorganisms, we are inviting you to send contributions concerning any aspect related to the evolution of DNA and RNA viruses with the potential to affect animal populations (including livestock, companion, and wild animals). We are welcoming multiple categories of original studies involving in-silico, in-vitro and in-vivo approaches intended to decipher the evolutionary dynamics of DNA and RNA viruses. We are also considering the publication of review articles, perspective and commentary papers, and letters to the editor, among other formats.

Dr. Lauro Velazquez-Salinas
Dr. Anna Munsey
Guest Editors

Manuscript Submission Information

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Keywords

  • natural selection
  • molecular epidemiology
  • recombination
  • phylogenetics
  • codon usage
  • dinucleotide usage
  • African swine fever virus
  • classical swine fever virus
  • foot and mouth disease virus
  • SARS-CoV-2
  • Mpox virus

Published Papers (1 paper)

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Research

13 pages, 7159 KiB  
Article
Phylogenetic and Structural Analysis of Porcine Circovirus Type 2 from 2016 to 2021 in Jilin Province, China
by Si Chen, Xue Li, Liying Zhang, Jiawei Zheng, Lin Yang, Guyu Niu, Huimin Zhang, Ying Ren, Jing Qian, Changjiang Sun and Linzhu Ren
Microorganisms 2023, 11(4), 983; https://doi.org/10.3390/microorganisms11040983 - 10 Apr 2023
Cited by 2 | Viewed by 1399
Abstract
Porcine circovirus disease (PCVD) caused by porcine circovirus type 2 (PCV2) is widely distributed in pig farms. Up until now, nine genotypes of PCV2, PCV2a to 2i, have been identified in diseased pigs worldwide. This study analyzed 302 samples collected in the Jilin [...] Read more.
Porcine circovirus disease (PCVD) caused by porcine circovirus type 2 (PCV2) is widely distributed in pig farms. Up until now, nine genotypes of PCV2, PCV2a to 2i, have been identified in diseased pigs worldwide. This study analyzed 302 samples collected in the Jilin Province of China from 2016 to 2021, followed by genetic analysis of the PCV2 isolates. Meanwhile, the antigen epitopes, amino acid mutations, 3D structure of the PCV2 isolates and commercially available vaccine strains were evaluated and compared. The results showed that the predominant genotypes of PCV2 were PCV2b, followed by PCV2e and PCV2d in Jilin Province during 2016–2021. Although mutations were detected in the isolates, no recombination occurred in the PCV2 isolates, indicating a stable genotype of PCV2 in Jilin Province during these years. Moreover, the B cell epitopes in the Cap and Rep proteins of eighteen PCV2 isolates and T cell epitopes in the Cap of the isolates were changed compared to three currently used vaccine strains. The mutations in the Cap and Rep proteins did not affect their spatial conformation. Therefore, bivalent or multivalent vaccines with different genotypes of PCV2 might improve the protective effect of vaccines. Full article
(This article belongs to the Special Issue Animal Viral Evolution)
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