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Microorganisms
Special Issues
The Role of Microorganism in Gestational Diabetes Mellitus 2.0
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The Role of Microorganism in Gestational Diabetes Mellitus 2.0

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Medical Microbiology".

Deadline for manuscript submissions: closed (29 February 2024) | Viewed by 6080

Special Issue Editors

Dr. Zohar Nachum

E-Mail Website
Guest Editor
1. Department of Obstetrics and Gynecology, Emek Medical Center, Afula 1834111, Israel
2. Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa 3200003, Israel
Interests: maternal; fetal; medicine; diabetes in pregnancy; microbiome
Special Issues, Collections and Topics in MDPI journals
Dr. Enav Yefet

E-Mail Website
Guest Editor
1. Department of Obstetrics & Gynecology, Baruch Padeh Medical Center Poriya, Tiberias 1410000, Israel
2. Azrieli Faculty of Medicine, Bar Ilan University, Safed 1310000, Israel
Interests: maternal; fetal medicine; diabetes; microbiome
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Gestational diabetes mellitus (GDM) complicates 4–12% of pregnancies and is considered one of the most prevalent pregnancy complications. The severe maternal and neonatal morbidities associated with uncontrolled GDM underscores the importance of adequate glucose control during pregnancy.

In recent years, the role of the intestinal microbiome in the context of metabolic diseases, particularly in glucose and insulin metabolism, has attracted a lot of attention. In parallel, a growing body of evidence has shown that probiotic supplements improve glucose metabolism by increasing host insulin sensitivity, cholesterol metabolism, and having a beneficial effect on the immune system. More specifically, they have been shown to reduce fasting glucose and hemoglobin A1C levels in non-pregnant individuals with diabetes. The characteristics common to GDM and diabetes mellitus have raised questions regarding the metabolic effects of the microbiome and probiotic treatments in women with GDM.

The aim of this Special Issue is to provide a collection of articles that showcase the current research of “The Role of Microorganism in Gestational Diabetes Mellitus”. As Guest Editors of this Special Issue, we invite you to submit research articles, review articles, and short communications related to this topic.

Dr. Zohar Nachum
Dr. Enav Yefet
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gestational diabetes mellitus
  • microbiome
  • glycemic control
  • glucose and insulin metabolism obstetric complications
  • probiotics
  • lactobacilli
  • obesity
  • weight gain
  • fat metabolism

Published Papers (3 papers)

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Review

22 pages, 6959 KiB  
Review
Gestational Diabetes and the Gut Microbiota: Fibre and Polyphenol Supplementation as a Therapeutic Strategy
by Carmen Pheiffer, Sylvia Riedel, Stephanie Dias and Sumaiya Adam
Microorganisms 2024, 12(4), 633; https://doi.org/10.3390/microorganisms12040633 - 22 Mar 2024
Viewed by 1018
Abstract
Gestational diabetes mellitus (GDM) is an escalating public health concern due to its association with short- and long-term adverse maternal and child health outcomes. Dysbiosis of microbiota within the gastrointestinal tract has been linked to the development of GDM. Modification of microbiota dysbiosis [...] Read more.
Gestational diabetes mellitus (GDM) is an escalating public health concern due to its association with short- and long-term adverse maternal and child health outcomes. Dysbiosis of microbiota within the gastrointestinal tract has been linked to the development of GDM. Modification of microbiota dysbiosis through dietary adjustments has attracted considerable attention as adjunct strategies to improve metabolic disease. Diets high in fibre and polyphenol content are associated with increased gut microbiota alpha diversity, reduced inflammation and oxidative processes and improved intestinal barrier function. This review explores the potential of fibre and polyphenol supplementation to prevent GDM by investigating their impact on gut microbiota composition and function. Full article
(This article belongs to the Special Issue The Role of Microorganism in Gestational Diabetes Mellitus 2.0)
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21 pages, 1764 KiB  
Review
The Maternal Microbiome and Gestational Diabetes Mellitus: Cause and Effect
by Stephanie Dias, Carmen Pheiffer and Sumaiya Adam
Microorganisms 2023, 11(9), 2217; https://doi.org/10.3390/microorganisms11092217 - 31 Aug 2023
Cited by 1 | Viewed by 1657
Abstract
Gestational diabetes mellitus (GDM) is a growing public health concern that affects many pregnancies globally. The condition is associated with adverse maternal and neonatal outcomes including gestational hypertension, preeclampsia, placental abruption, preterm birth, stillbirth, and fetal growth restriction. In the long-term, mothers and [...] Read more.
Gestational diabetes mellitus (GDM) is a growing public health concern that affects many pregnancies globally. The condition is associated with adverse maternal and neonatal outcomes including gestational hypertension, preeclampsia, placental abruption, preterm birth, stillbirth, and fetal growth restriction. In the long-term, mothers and children have an increased risk of developing metabolic diseases such as type 2 diabetes and cardiovascular disease. Accumulating evidence suggest that alterations in the maternal microbiome may play a role in the pathogenesis of GDM and adverse pregnancy outcomes. This review describes changes in the maternal microbiome during the physiological adaptations of pregnancy, GDM and adverse maternal and neonatal outcomes. Findings from this review highlight the importance of understanding the link between the maternal microbiome and GDM. Furthermore, new therapeutic approaches to prevent or better manage GDM are discussed. Further research and clinical trials are necessary to fully realize the therapeutic potential of the maternal microbiome and translate these findings into clinical practice. Full article
(This article belongs to the Special Issue The Role of Microorganism in Gestational Diabetes Mellitus 2.0)
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14 pages, 1283 KiB  
Review
The Association between Gestational Diabetes Mellitus and Infections in Pregnancy—Systematic Review and Meta-Analysis
by Enav Yefet, Aviv Bejerano, Rula Iskander, Tal Zilberman Kimhi and Zohar Nachum
Microorganisms 2023, 11(8), 1956; https://doi.org/10.3390/microorganisms11081956 - 31 Jul 2023
Cited by 2 | Viewed by 2735
Abstract
We conducted a systematic review and meta-analysis to evaluate the association between gestational diabetes mellitus and infections during pregnancy. We included cross-sectional, case-control, cohort studies and clinical trials, evaluating the frequency of infections in women with and without gestational diabetes mellitus. A search [...] Read more.
We conducted a systematic review and meta-analysis to evaluate the association between gestational diabetes mellitus and infections during pregnancy. We included cross-sectional, case-control, cohort studies and clinical trials, evaluating the frequency of infections in women with and without gestational diabetes mellitus. A search was conducted in Embase, PubMed, and Web of Science electronic databases and by manually searching references, until 23 March 2022, resulting in 16 studies being selected for review, with 111,649 women in the gestational diabetes mellitus group, and 1,429,659 in the controls. Cochrane’s Q test of heterogeneity and I² were used to assess heterogeneity. Pooled odds ratio (OR) was calculated. Funnel plots and Egger test were used for assessment of publication bias. The results showed a significant association between gestational diabetes mellitus and infections (pooled-OR 1.3 95% CI [1.2–1.5]). Sub-analyses showed a significant association for urinary tract infections (pooled-OR of 1.2 95% CI [1.1–1.3]), bacterial infections (pooled-OR were 1.2 95% CI [1.1–1.4]), and SARS-CoV-2 (pooled-OR 1.5 95% CI [1.2–2.0]) but not to gingivitis or vaginal candidiasis. The results underscore the significance of acknowledging gestational diabetes mellitus as a risk factor for infections. Full article
(This article belongs to the Special Issue The Role of Microorganism in Gestational Diabetes Mellitus 2.0)
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