Molecular Epidemiology of Leishmaniasis

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Parasitology".

Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 802

Special Issue Editor

Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, 1349-008 Lisbon, Portugal
Interests: helminths; leishmaniasis; genetic diversity; genotyping; molecular epidemiology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The molecular epidemiology of leishmaniasis is a developing field that has been revolutionised by the emergence of genomic epidemiology and population genetics, as well as deep sequencing applications to study population diversity within hosts, which also inform the development of improved diagnostic and genotyping methods.

This Special Issue will accept Original Research Articles and Reviews that cover all aspects related to the molecular epidemiology of leishmaniasis, including, but not limited to, genomic epidemiology, the development, application, and validation of improved genetic markers in diagnosis and genotyping, and studies that use molecular markers and genome sequences to elucidate transmission, association with clinical presentation, new reservoir hosts or vectors, and the taxonomy of leishmaniasis.

Dr. Isabel Mauricio
Guest Editor

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Keywords

  • leishmaniasis
  • molecular epidemiology
  • genomic epidemiology
  • genetic markers
  • transmission
  • molecular diagnosis
  • molecular taxonomy

Published Papers (1 paper)

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Research

12 pages, 649 KiB  
Article
Coinfection with Leishmania infantum and Toxoplasma gondii in Domestic Cats from a Region with a High Prevalence of Feline Immunodeficiency Virus
Microorganisms 2024, 12(1), 71; https://doi.org/10.3390/microorganisms12010071 - 29 Dec 2023
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Abstract
The aim of this study was to investigate the coinfection of feline retroviruses (feline immunodeficiency virus—FIV, and the feline leukemia virus—FeLV) with Leishmania infantum and Toxoplasma gondii and the factors associated with these pathogens in domestic cats from Mossoró, a city endemic for [...] Read more.
The aim of this study was to investigate the coinfection of feline retroviruses (feline immunodeficiency virus—FIV, and the feline leukemia virus—FeLV) with Leishmania infantum and Toxoplasma gondii and the factors associated with these pathogens in domestic cats from Mossoró, a city endemic for canine and human leishmaniasis situated in the semiarid region of Northeast Brazil. Blood samples from 120 cats were collected, and an epidemiological questionnaire was applied to investigate the risk factors associated with the infections. Retroviruses, L. infantum, and T. gondii infections were assessed using a point-of-care ELISA and quantitative PCR (qPCR), indirect fluorescent antibody test (IFAT) and qPCR, and IFAT, respectively. The overall seroprevalences observed were 35% (95% CI = 27.0–43.8%) for FIV, 0.8% (95% CI = 0.1–4.5%) for FeLV, 25.8% (95% CI = 18.8–34.3%) for T. gondii, and 4.2% (95% CI = 1.7–9.3%) for L. infantum. Coinfection with FIV and L. infantum was observed in 2.5% (3/120) of the assessed cats, while 12.5% (15/120) were coinfected with FIV and T. gondii. No significant association was found among the investigated agents (p > 0.05). The factors associated with FIV infection in the multivariable analysis were male sex and age above 78 months. The findings of this study demonstrated a high rate of FIV infection in cats from the Brazilian semiarid region and the exposure of these animals to zoonotic and opportunistic agents. Due to the immunosuppressive potential of FIV, cats infected with this retrovirus should be screened for coinfections with L. infantum and T. gondii, and preventative measures should be adopted. Full article
(This article belongs to the Special Issue Molecular Epidemiology of Leishmaniasis)
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