Host Versus Pathogen: Candida Infections, Immune Response and Therapy Perspectives

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Molecular Microbiology and Immunology".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 719

Special Issue Editors


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Guest Editor
Department of Surgical, Medical, Dental and Morphological Sciences with Interest in Transplant, Oncological and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy
Interests: innate immunity to fungal infections; Candida; mucosal candidiasis; microbiota and mycobiota; fungal and bacterial biofilm; antifungal strategies

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Guest Editor
Geoffrey Pope Building, University of Exeter , Stocker Road, Exeter, EX4 4QD, UK
Interests: C. albicans; Candida; candidiasis

Special Issue Information

Dear Colleagues,

Candida spp. can be detected on the mucosal surfaces of around 50–70% of healthy individuals but it can also induce a wide range of cutaneous, mucosal and systemic infections every year under predisposing conditions, such us breaches in intestinal barriers, dysbiosis and immunodeficiency.

Candida albicans is considered the main human fungal pathogen, but recently there has been an increase in infections induced by non-albicans Candida species. One of the species causing the greatest global concern is Candida auris, an emerging multidrug-resistant strain, first described in Japan in 2009, that has recently been included in the group of the critical priority fungal pathogens by the WHO.

The interplay between Candida spp. and the host immune system is fundamental to resolving the infection and, after initial recognition, innate and adaptive immune cells as well as non-immune cells, contribute to the antifungal response.

This Special Issue of Microorganisms aims to provide a collection of articles highlighting recent discoveries and advances in the field of Candida study, from the perspectives of both the host and the pathogen. Studies regarding potential new therapeutic approaches and those on the role of the interactions with other microorganisms during the infection process are also welcome.

As Guest Editors of this Special Issue, we invite you to submit research articles, reviews, and short communications covering a range of Candida infections and the host immune response they elicit.

We look forward to receiving your contributions.

Dr. Eva Pericolini
Dr. Elena Roselletti
Guest Editors

Manuscript Submission Information

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Keywords

  • Candida spp.
  • candidiasis
  • mucosal infection
  • invasive infection
  • innate immune response
  • adaptive immune response
  • drug resistance
  • anti-Candida therapies

Published Papers (1 paper)

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Review

16 pages, 2481 KiB  
Review
Candida auris Outbreaks: Current Status and Future Perspectives
by Silvia De Gaetano, Angelina Midiri, Giuseppe Mancuso, Maria Giovanna Avola and Carmelo Biondo
Microorganisms 2024, 12(5), 927; https://doi.org/10.3390/microorganisms12050927 - 1 May 2024
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Abstract
Candida auris has been identified by the World Health Organization (WHO) as a critical priority pathogen on its latest list of fungi. C. auris infections are reported in the bloodstream and less commonly in the cerebrospinal fluid and abdomen, with mortality rates that [...] Read more.
Candida auris has been identified by the World Health Organization (WHO) as a critical priority pathogen on its latest list of fungi. C. auris infections are reported in the bloodstream and less commonly in the cerebrospinal fluid and abdomen, with mortality rates that range between 30% and 72%. However, no large-scale epidemiology studies have been reported until now. The diagnosis of C. auris infections can be challenging, particularly when employing conventional techniques. This can impede the early detection of outbreaks and the implementation of appropriate control measures. The yeast can easily spread between patients and in healthcare settings through contaminated environments or equipment, where it can survive for extended periods. Therefore, it would be desirable to screen patients for C. auris colonisation. This would allow facilities to identify patients with the disease and take appropriate prevention and control measures. It is frequently unsusceptible to drugs, with varying patterns of resistance observed among clades and geographical regions. This review provides updates on C. auris, including epidemiology, clinical characteristics, genomic analysis, evolution, colonisation, infection, identification, resistance profiles, therapeutic options, prevention, and control. Full article
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