New Strategies for Pathogenic Biofilms

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Biofilm".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 1879

Special Issue Editor

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Guest Editor
Department of Biology and Environment Science, University of New Haven, West Haven, CT 06516, USA
Interests: Lyme disease; spirochetes; infection; biofilm; persisters; antibiotic resistance; connection of cancer to bacterial infections
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Special Issue Information

Dear Colleagues,

Biofilms have a crucial role in the pathogenesis of probably most human chronic diseases.

The biofilm form is a very effective refuge for harboring cells since it provides high resistance to environmental stressors, including the immune system and therapeutic interventions. One of the defensive strategies is a protective layer consisting of a mixture of extracellular polymeric substances (EPSs) secreted by the cells established within the biofilm. Furthermore, inside the biofilm, the bacteria create unique social interactions and launch various defensive strategies to protect the community.

Biofilm strategies for antimicrobial agents are very different from planktonic cells and include an EPS barrier for antibiotics, production of an altered chemical environment, as well as a very specific subpopulation of cells called persisters. Therefore, clinical intervention against pathogenic biofilms cannot be based solely on our knowledge derived from the resistance mechanisms of planktonic cells.

Furthermore, recent findings from classical in vitro studies on biofilm development and antibiotic sensitivity failed to capture the true biofilm physiology in clinical and environmental settings. There is an urgent need to find novel model systems to better understand pathogenic biofilms and find novel therapeutic strategies to inhibit and eliminate this resistant form.

Additionally, recent reports suggest that the interaction of the immune system with pathogenic biofilms is very different from planktonic cells and, unfortunately, not well studied. Therefore, we need to rethink how we research host immune system responses in biofilm-related chronic diseases.

In summary, a clear understanding of the exact mechanism of biofilm development and its resistance strategies against the immune system and antibiotics, as they function in model systems that mimic clinical conditions, could help us develop therapeutic targets for chronic conditions caused by pathogenic biofilms.

This Special Issue seeks manuscript submissions for novel model systems to study biofilm physiology, host immune response, and new therapeutic approaches for pathogenic biofilms such as original research papers, short communications, reviews, case reports, and perspectives.

Prof. Dr. Eva Sapi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • pathogenic biofilm physiology
  • host immune response
  • new model system
  • therapeutic approaches for biofilms

Published Papers (1 paper)

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21 pages, 3506 KiB  
Elimination of Pathogen Biofilms via Postbiotics from Lactic Acid Bacteria: A Promising Method in Food and Biomedicine
by Jiahao Che, Jingjing Shi, Chenguang Fang, Xiaoqun Zeng, Zhen Wu, Qiwei Du, Maolin Tu and Daodong Pan
Microorganisms 2024, 12(4), 704; - 30 Mar 2024
Viewed by 1568
Pathogenic biofilms provide a naturally favorable barrier for microbial growth and are closely related to the virulence of pathogens. Postbiotics from lactic acid bacteria (LAB) are secondary metabolites and cellular components obtained by inactivation of fermentation broth; they have a certain inhibitory effect [...] Read more.
Pathogenic biofilms provide a naturally favorable barrier for microbial growth and are closely related to the virulence of pathogens. Postbiotics from lactic acid bacteria (LAB) are secondary metabolites and cellular components obtained by inactivation of fermentation broth; they have a certain inhibitory effect on all stages of pathogen biofilms. Postbiotics from LAB have drawn attention because of their high stability, safety dose parameters, and long storage period, which give them a broad application prospect in the fields of food and medicine. The mechanisms of eliminating pathogen biofilms via postbiotics from LAB mainly affect the surface adhesion, self-aggregation, virulence, and QS of pathogens influencing interspecific and intraspecific communication. However, there are some factors (preparation process and lack of target) which can limit the antibiofilm impact of postbiotics. Therefore, by using a delivery carrier and optimizing process parameters, the effect of interfering factors can be eliminated. This review summarizes the concept and characteristics of postbiotics from LAB, focusing on their preparation technology and antibiofilm effect, and the applications and limitations of postbiotics in food processing and clinical treatment are also discussed. Full article
(This article belongs to the Special Issue New Strategies for Pathogenic Biofilms)
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