Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
6.4
4.5
Journals
Microorganisms
Special Issues
Prevention and Treatment of Helicobacter pylori Infection Related Gastrointestinal Disease
share announcement

Prevention and Treatment of Helicobacter pylori Infection Related Gastrointestinal Disease

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Medical Microbiology".

Deadline for manuscript submissions: 31 May 2024 | Viewed by 4992

Special Issue Editor

Dr. Ping I. Hsu

E-Mail Website
Guest Editor
An Nan Hospital, China Medical University, Taichung, Taiwan
Interests: prevention and treatment of the peptic ulcer disease; gastric cancer and Helicobacter pylori (H. pylori) infection

Special Issue Information

Dear Colleagues,

This Special Issue, titled "Prevention and treatment of Helicobacter pylori (H. pylori) infection related gastrointestinal disease", explores the prevention and treatment of gastrointestinal diseases caused by H. pylori infection. The Special Issue features several research articles that investigate the epidemiology, diagnosis, and treatment of H. pylori infection and its associated diseases.

One of the key findings of this Special Issue is the importance of H. pylori eradication in the prevention and treatment of gastrointestinal diseases. H. pylori is a common bacterial infection that can lead to various gastrointestinal diseases such as peptic ulcer disease, gastric cancer, and gastric mucosa-associated lymphoid tissue (MALT) lymphoma. Several studies featured in this Special Issue investigate the efficacy of different treatment regimens for H. pylori eradication, as well as the impact of eradication on the prevention and treatment of associated diseases.

This Special Issue also highlights the challenges of diagnosing H. pylori infection. Several studies featured in the Special Issue investigate the accuracy and reliability of different diagnostic tests for H. pylori infection, such as serology, urea breath test, and stool antigen test.

Another important theme in this Special Issue is the potential role of probiotics in the prevention and treatment of H. pylori infection. Several studies featured in the Special Issue investigate the impact of probiotics on H. pylori colonization and associated diseases. While some studies have shown promising results, others have found no significant benefit from probiotic supplementation.

Finally, the Special Issue also highlights the need for further research into the prevention and treatment of H. pylori infection and associated diseases. Several studies featured in the Special Issue investigate the mechanisms by which H. pylori infection leads to gastrointestinal diseases, as well as the impact of environmental and genetic factors on disease risk.

Overall, the Special Issue "Prevention and Treatment of Helicobacter pylori Infection Related Gastrointestinal Disease" highlights the importance of H. pylori eradication in the prevention and treatment of associated diseases, as well as the challenges involved in diagnosing and treating H. pylori infection. The research presented in this issue provides valuable insights into the epidemiology, diagnosis, and treatment of H. pylori infection and its associated diseases, and highlights the need for further research in this area.

Dr. Ping I. Hsu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Helicobacter pylori (H. pylori)
  • prevention
  • treatment
  • gastrointestinal disease

Published Papers (3 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

11 pages, 271 KiB  
Article
Independent Risk Factors Predicting Eradication Failure of Hybrid Therapy for the First-Line Treatment of Helicobacter pylori Infection
by Chien-Lin Chen, I-Ting Wu, Deng-Chyang Wu, Wei-Yi Lei, Feng-Woei Tsay, Seng-Kee Chuah, Kuan-Yang Chen, Jyh-Chin Yang, Yu-Hwa Liu, Chao-Hung Kuo, Sz-Iuan Shiu, Chang-Bih Shie, Kuan-Hua Lin, Chia-Long Lee and Ping-I Hsu
Microorganisms 2024, 12(1), 6; https://doi.org/10.3390/microorganisms12010006 - 19 Dec 2023
Cited by 2 | Viewed by 880
Abstract
Hybrid therapy is a recommended first-line anti-H. pylori treatment option in the American College of Gastroenterology guidelines, the Bangkok Consensus Report on H. pylori management, and the Taiwan H. pylori Consensus Report. However, the cure rates of eradication therapy in some countries [...] Read more.
Hybrid therapy is a recommended first-line anti-H. pylori treatment option in the American College of Gastroenterology guidelines, the Bangkok Consensus Report on H. pylori management, and the Taiwan H. pylori Consensus Report. However, the cure rates of eradication therapy in some countries are suboptimal, and the factors affecting the treatment efficacy of hybrid therapy remain unclear. The aim of this study is to identify the independent risk factors predicting eradication failure of hybrid therapy in the first-line treatment of H. pylori infection. A retrospective cohort study was conducted on 589 H. pylori-infected patients who received 14-day hybrid therapy between September 2008 and December 2021 in ten hospitals in Taiwan. The patients received a hybrid therapy containing a dual regimen with a proton pump inhibitor (PPI) plus amoxicillin for an initial 7 days and a quadruple regimen with a PPI plus amoxicillin, metronidazole and clarithromycin for a final 7 days. Post-treatment H. pylori status was assessed at least 4 weeks after completion of treatment. The relationships between eradication rate and 13 host and bacterial factors were investigated via univariate and multivariate analyses. In total, 589 patients infected with H. pylori infection were included in the study. The eradication rates of hybrid therapy were determined as 93.0% (95% confidence interval (CI): 90.9–95.1%), 94.4% (95% CI: 93.8–97.2%) and 95.5%% (95% CI: 93.8–97.2%) by intention-to-treat, modified intention-to-treat and per-protocol analyses, respectively. Univariate analysis showed that the eradication rate of clarithromycin-resistant strains was lower than that of clarithromcyin-susceptible strains (83.3% (45/54) vs. 97.6%% (280/287); p < 0.001). Subjects with poor drug adherence had a lower cure rate than those with good adherence (73.3% (11/15) vs. 95.5% (534/559); p = 0.005). Other factors such as smoking, alcohol drinking, coffee consumption, tea consumption and type of PPI were not significantly associated with cure rate. Multivariate analysis revealed that clarithromcyin resistance of H. pylori and poor drug adherence were independent risk factors related to eradication failure of hybrid therapy with odds ratios of 4.8 (95% CI: 1.5 to 16.1; p = 0.009) and 8.2 (95% CI: 1.5 to 43.5; p = 0.013), respectively. A 14-day hybrid therapy has a high eradication rate for H. pylori infection in Taiwan, while clarithromycin resistance of H. pylori and poor drug adherence are independent risk factors predicting eradication failure of hybrid therapy. Full article
(This article belongs to the Special Issue Prevention and Treatment of Helicobacter pylori Infection Related Gastrointestinal Disease)
15 pages, 6790 KiB  
Article
Notch Signaling Regulates the Function and Phenotype of Dendritic Cells in Helicobacter pylori Infection
by Qiaoyuan Liu, Chuxi Chen, Yunxuan He, Wenhao Mai, Shipeng Ruan, Yunshan Ning and Yan Li
Microorganisms 2023, 11(11), 2818; https://doi.org/10.3390/microorganisms11112818 - 20 Nov 2023
Cited by 2 | Viewed by 1013
Abstract
Notch signaling manipulates the function and phenotype of dendritic cells (DCs), as well as the interaction between DCs and CD4+ T cells. However, the role of Notch signaling in Helicobacter pylori (H. pylori) infection remains elusive. Murine bone marrow-derived dendritic [...] Read more.
Notch signaling manipulates the function and phenotype of dendritic cells (DCs), as well as the interaction between DCs and CD4+ T cells. However, the role of Notch signaling in Helicobacter pylori (H. pylori) infection remains elusive. Murine bone marrow-derived dendritic cells (BMDCs) were pretreated in the absence or presence of Notch signaling inhibitor DAPT prior to H. pylori stimulation and the levels of Notch components, cytokines and surface markers as well as the differentiation of CD4+ T cells in co-culture were measured using quantitative real-time PCR (qRT-PCR), Western blot, enzyme-linked immunosorbent assay (ELISA) and flow cytometry. Compared with the control, the mRNA expression of all Notch receptors and Notch ligands Dll4 and Jagged1 was up-regulated in H. pylori-stimulated BMDCs. The blockade of Notch signaling by DAPT influenced the production of IL-1β and IL-10 in H. pylori-pulsed BMDCs, and reduced the expression of Notch1, Notch3, Notch4, Dll1, Dll3 and Jagged2. In addition, DAPT pretreatment decreased the expression of maturation markers CD80, CD83, CD86, and major histocompatibility complex class II (MHC-II) of BMDCs, and further skewed Th17/Treg balance toward Treg. Notch signaling regulates the function and phenotype of DCs, thus mediating the differentiation of CD4+ T cells during H. pylori infection. Full article
(This article belongs to the Special Issue Prevention and Treatment of Helicobacter pylori Infection Related Gastrointestinal Disease)
►▼ Show Figures

Figure 1

Review

Jump to: Research

19 pages, 1074 KiB  
Review
Helicobacter pylori: A Contemporary Perspective on Pathogenesis, Diagnosis and Treatment Strategies
by Asghar Ali and Khalid I. AlHussaini
Microorganisms 2024, 12(1), 222; https://doi.org/10.3390/microorganisms12010222 - 22 Jan 2024
Viewed by 2838
Abstract
Helicobacter pylori (H. pylori) is a Gram-negative bacterium that colonizes the gastric mucosa and is associated with various gastrointestinal disorders. H. pylori is a pervasive pathogen, infecting nearly 50% of the world’s population, and presents a substantial concern due to its [...] Read more.
Helicobacter pylori (H. pylori) is a Gram-negative bacterium that colonizes the gastric mucosa and is associated with various gastrointestinal disorders. H. pylori is a pervasive pathogen, infecting nearly 50% of the world’s population, and presents a substantial concern due to its link with gastric cancer, ranking as the third most common cause of global cancer-related mortality. This review article provides an updated and comprehensive overview of the current understanding of H. pylori infection, focusing on its pathogenesis, diagnosis, and treatment strategies. The intricate mechanisms underlying its pathogenesis, including the virulence factors and host interactions, are discussed in detail. The diagnostic methods, ranging from the traditional techniques to the advanced molecular approaches, are explored, highlighting their strengths and limitations. The evolving landscape of treatment strategies, including antibiotic regimens and emerging therapeutic approaches, is thoroughly examined. Through a critical synthesis of the recent research findings, this article offers valuable insights into the contemporary knowledge of Helicobacter pylori infection, guiding both clinicians and researchers toward effective management and future directions in combating this global health challenge. Full article
(This article belongs to the Special Issue Prevention and Treatment of Helicobacter pylori Infection Related Gastrointestinal Disease)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-3
Back to TopTop