Resilient Biofilms and Their Control

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Biofilm".

Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 1239

Special Issue Editors


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Guest Editor
Department of Plant Pathology and Microbiology, Jerusalem, Israel
Interests: ecology and evolution of predatory bacteria; the growth cycle of Bdellovibrio and like organisms; structure and functions of fruit flies-associated microbiota; molecular profiling of bacterial soil communities

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Guest Editor
Cavendish Laboratory, Department of Physics, University of Cambridge, 19 JJ Thomson Avenue, Cambridge CB3 0HE, UK
Interests: predatory bacteria; bofilm; antimicrobial resistance

Special Issue Information

Dear Colleagues,

Biofilms are a microbial community comprising clusters of cells embedded within a matrix of extracellular polymeric substances (EPS). Extracellular proteins, DNA and carbohydrates are the main constituents of their EPS, which are further stabilized in the presence of particular cations. Biofilm development is often regulated by quorum sensing and other regulatory networks including secondary messengers such as cyclic AMP and cyclic-di-GMP. The collective properties of the biofilm structure, the metabolic adaptability of the microorganisms within, and their ability to sense and respond to environmental cues contribute to biofilm resistance against various physical and chemical stressors, such as nutrient limitation and host-immune system. One such resultant fitness gain is antibiotic resistance, which has large negative impacts on medicine, industry, agriculture, and environmental management, among others. Understanding the evolution of biofilms by examining their formation, development, and persistence over time can help in developing strategies to manage biofilm-related problems.

This Special Issue calls for papers that will promote the understanding of the evolution of biofilm development, sustenance, and control within the following sub-topics:

  1. Biofilms as main supports of microbial life;
  2. Mechanisms of biofilm development under stressful conditions and in extreme environments;
  3. Coping with biofilm life at the cell level;
  4. The stress sensitivity to resistance continuum in biofilms;
  5. Novel ideas for an old problem: biofilm control.

We look forward to receiving your contributions.

Prof. Dr. Édouard J. Jurkevitch
Dr. Abhirup Mookherjee
Guest Editors

Manuscript Submission Information

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Keywords

  • resilient biofilm
  • biofilm evolution
  • antibiotic resistance
  • biofilm control
  • host-immune system
  • quorum sensing

Published Papers (1 paper)

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Research

10 pages, 1894 KiB  
Article
Biofilm Removal from In Vitro Narrow Geometries Using Single and Dual Pulse Er:YAG Laser Photoacoustic Irrigation
by Saša Terlep, Iztok Dogsa, Franja Pajk and David Stopar
Microorganisms 2023, 11(8), 2102; https://doi.org/10.3390/microorganisms11082102 - 17 Aug 2023
Cited by 3 | Viewed by 1086
Abstract
The disinfection and removal of biofilm from titanium dental implants remains a great challenge in oral medicine. Here we present results of novel photoacoustic irrigation laser modalities for biofilm removal in model geometries mimicking the peri-implant pocket. The efficacy of single pulse (Er:YAG-SSP) [...] Read more.
The disinfection and removal of biofilm from titanium dental implants remains a great challenge in oral medicine. Here we present results of novel photoacoustic irrigation laser modalities for biofilm removal in model geometries mimicking the peri-implant pocket. The efficacy of single pulse (Er:YAG-SSP) and dual pulse (Er:YAG-AutoSWEEPS) photoacoustic irrigation modalities were determined for Enterococcus faecalis biofilm decontamination from titanium surfaces in narrow cylindrical and square gap geometries. The density of bacteria as well as the number of live bacteria were determined prior and after different photoacoustic treatments. Both SSP and AutoSWEEPS photoacoustic irrigation techniques removed at least 92% of biofilm bacteria during the 10 s photoacoustic treatment. The effectiveness of cleaning was better in the narrow square gap geometry compared to the cylindrical geometry. The dual pulse Er:YAG-AutoSWEEPS photoacoustic irrigation showed better results compared to SSP modality. No chemical adjuvants were needed to boost the effectiveness of the photoacoustic irrigation in the saline solution. The results imply that photoacoustic irrigation is an efficient cleaning method for debridement and decontamination in narrow geometries and should be considered as a new therapeutic option for the treatment of peri-implant diseases. Full article
(This article belongs to the Special Issue Resilient Biofilms and Their Control)
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