Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
6.4
4.5
Journals
Microorganisms
Special Issues
Novel Strategies to Combat Antimicrobial Resistance
share announcement

Novel Strategies to Combat Antimicrobial Resistance

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Antimicrobial Agents and Resistance".

Deadline for manuscript submissions: closed (20 October 2023) | Viewed by 1420

Special Issue Editors

Dr. Giuseppina Mandalari

E-Mail Website
Guest Editor
Department of Chemical, Biological, Pharmaceutical and Environmental Science, University of Messina, 98168 Messina, Italy
Interests: antimicrobials; nutraceuticals; in vitro digestion; nutrients and phytochemicals release; gut health
Special Issues, Collections and Topics in MDPI journals
Dr. Teresa Gervasi

E-Mail Website
Guest Editor
Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98168 Messina, Italy
Interests: microbial fermentation; by-product valorization; probiotics; gut microbiota; antimicrobial compounds; functional food
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Antimicrobials have been widely studied from various sources including plants and microorganisms, as well as semi-synthetic and synthetic origins. Antimicrobial resistance represents a major threat worldwide, reducing our ability to cure a wide range of infectious disease. The purpose of this Special Issue is to receive original research articles and reviews that focus on up-to-date Antimicrobial Agents which are essential to combat the growing number of emerging pathogens. We believe that this Special Issue can provide new insights into the current understanding of antimicrobial agents and resistance.

Dr. Giuseppina Mandalari
Dr. Teresa Gervasi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antimicrobial
  • antiviral
  • plant bioactives
  • drug resistance
  • association
  • synergism

Published Papers (1 paper)

Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

20 pages, 6182 KiB  
Article
Relocating Glyceryl Trinitrate as an Anti-Virulence Agent against Pseudomonas aeruginosa and Serratia marcescens: Insights from Molecular and In Vivo Investigations
by Shaimaa I. Nazeih, Mohamed A. M. Ali, Alyaa S. Abdel Halim, Hanan Al-Lawati, Hisham A. Abbas, Mohammed Al-Zharani, Fehmi Boufahja, Mashael A. Alghamdi, Wael A. H. Hegazy and Noura M. Seleem
Microorganisms 2023, 11(10), 2420; https://doi.org/10.3390/microorganisms11102420 - 28 Sep 2023
Cited by 4 | Viewed by 1149
Abstract
The problem of antibiotic resistance is a global critical public health concern. In light of the threat of returning to the pre-antibiotic era, new alternative approaches are required such as quorum-sensing (QS) disruption and virulence inhibition, both of which apply no discernible selective [...] Read more.
The problem of antibiotic resistance is a global critical public health concern. In light of the threat of returning to the pre-antibiotic era, new alternative approaches are required such as quorum-sensing (QS) disruption and virulence inhibition, both of which apply no discernible selective pressure on bacteria, therefore mitigating the potential for the development of resistant strains. Bearing in mind the significant role of QS in orchestrating bacterial virulence, disrupting QS becomes essential for effectively diminishing bacterial virulence. This study aimed to assess the potential use of sub-inhibitory concentration (0.25 mg/mL) of glyceryl trinitrate (GTN) to inhibit virulence in Serratia marcescens and Pseudomonas aeruginosa. GTN could decrease the expression of virulence genes in both tested bacteria in a significant manner. Histopathological study revealed the ability of GTN to alleviate the congestion in hepatic and renal tissues of infected mice and to reduce bacterial and leukocyte infiltration. This study recommends the use of topical GTN to treat topical infection caused by P. aeruginosa and S. marcescens in combination with antibiotics. Full article
(This article belongs to the Special Issue Novel Strategies to Combat Antimicrobial Resistance)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-1
Back to TopTop