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Micromachines
Special Issues
Microfluidics on Printed Circuit Boards
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Microfluidics on Printed Circuit Boards

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "C：Chemistry".

Deadline for manuscript submissions: closed (31 October 2019) | Viewed by 6992

Special Issue Editors

Dr. Angeliki Tserepi

E-Mail Website
Guest Editor
Institute of Nanoscience & Nanotechnology, NCSR Demokritos, 153 10 Aghia Paraskevi, 60228 Athens, Greece
Interests: microfluidics on PCB; plasma surface engineering; lab-on-a-chip; biochips; point-of-care diagnostics; biomolecule microarrays
Dr. George Kokkoris

E-Mail Website
Guest Editor
Division of Process Analysis and Plant Design, School of Chemical Engineering, National Technical University of Athens, 15780 Athens, Greece
Interests: mutliscale modeling and simulation; plasma processing; microfluidic devices; lab on a chip systems
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Over the past twenty years, the rapidly increasing number of publications on lab-on-a-chip systems realized on printed circuit boards (PCB) is indicative of the future potential of the technology and its emerging applications. Indeed, the lab-on-printed circuit board (Lab-on-PCB) approach enables the seamless integration of microfluidics, sensors, and electronics, and promises the commercial upscalability and standardization of microfluidics, leveraging the well-established PCB industry with standardized fabrication facilities and processes. To make this vision possible, the research community is developing microfluidic devices and lab-on-a-chip systems using PCB-compatible materials and processes, while initiatives are being taken to bridge the gap between microfluidics research community and the PCB industry (www.eipc.org/eipcevent/2016-workshop-pcb-bio-mems/, www.eipc.org/news-eipc-3/). This Special Issue will focus on original articles, reviews, and perspectives of the field in terms of fabrication technology, prototype devices and systems, design and simulation, commercialization challenges, and applications.

Dr. Angeliki Tserepi
Dr. George Kokkoris
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • PCB-compatible fabrication
  • Integration technologies
  • Sealing and bonding
  • Design and simulation of PCB microfluidics
  • Microfluidic pumps/valves/mixers
  • DNA/RNA analysis
  • Droplet PCB-based microfluidics
  • PCB-based sensors & biosensors
  • Heterogeneous systems
  • Lab-on-PCB

Published Papers (2 papers)

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Research

16 pages, 4140 KiB  
Article
Towards PCB-Based Miniaturized Thermocyclers for DNA Amplification
by Georgia D. Kaprou, Vasileios Papadopoulos, Christos-Moritz Loukas, George Kokkoris and Angeliki Tserepi
Micromachines 2020, 11(3), 258; https://doi.org/10.3390/mi11030258 - 28 Feb 2020
Cited by 16 | Viewed by 3001
Abstract
In recent years, printed circuit board (PCB)-based microfluidics have been explored as a means to achieve standardization, seamless integration, and large-scale manufacturing of microfluidics, thus paving the way for widespread commercialization of developed prototypes. In this work, static micro polymerase chain reaction (microPCR) [...] Read more.
In recent years, printed circuit board (PCB)-based microfluidics have been explored as a means to achieve standardization, seamless integration, and large-scale manufacturing of microfluidics, thus paving the way for widespread commercialization of developed prototypes. In this work, static micro polymerase chain reaction (microPCR) devices comprising resistive microheaters integrated on PCBs are introduced as miniaturized thermocyclers for efficient DNA amplification. Their performance is compared to that of conventional thermocyclers, in terms of amplification efficiency, power consumption and duration. Exhibiting similar efficiency to conventional thermocyclers, PCB-based miniaturized thermocycling achieves faster DNA amplification, with significantly smaller power consumption. Simulations guide the design of such devices and propose means for further improvement of their performance. Full article
(This article belongs to the Special Issue Microfluidics on Printed Circuit Boards)
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9 pages, 2158 KiB  
Article
Label-Free Electrochemical Detection of S. mutans Exploiting Commercially Fabricated Printed Circuit Board Sensing Electrodes
by Gorachand Dutta, Abdoulie A. Jallow, Debjani Paul and Despina Moschou
Micromachines 2019, 10(9), 575; https://doi.org/10.3390/mi10090575 - 30 Aug 2019
Cited by 21 | Viewed by 3430
Abstract
This paper reports for the first time printed-circuit-board (PCB)-based label-free electrochemical detection of bacteria. The demonstrated immunosensor was implemented on a PCB sensing platform which was designed and fabricated in a standard PCB manufacturing facility. Bacteria were directly captured on the PCB sensing [...] Read more.
This paper reports for the first time printed-circuit-board (PCB)-based label-free electrochemical detection of bacteria. The demonstrated immunosensor was implemented on a PCB sensing platform which was designed and fabricated in a standard PCB manufacturing facility. Bacteria were directly captured on the PCB sensing surface using a specific, pre-immobilized antibody. Electrochemical impedance spectra (EIS) were recorded and used to extract the charge transfer resistance (Rct) value for the different bacteria concentrations under investigation. As a proof-of-concept, Streptococcus mutans (S. mutans) bacteria were quantified in a phosphate buffered saline (PBS) buffer, achieving a limit of detection of 103 CFU/mL. Therefore, the proposed biosensor is an attractive candidate for the development of a simple and robust point-of-care diagnostic platform for bacteria identification, exhibiting good sensitivity, high selectivity, and excellent reproducibility. Full article
(This article belongs to the Special Issue Microfluidics on Printed Circuit Boards)
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