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Micromachines
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Micro/Nanofluidic and Lab-on-a-Chip Devices for Biomedical Applications, 2nd Edition
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Micro/Nanofluidic and Lab-on-a-Chip Devices for Biomedical Applications, 2nd Edition

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "B：Biology and Biomedicine".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 3188

Special Issue Editors

Dr. Senhorinha de Fátima Capela Fortunas Teixeira

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Guest Editor
Department of Production Systems, University of Minho, 4800-058 Guimarães, Portugal
Interests: numerical modeling and optimization; two-phase flow; CFD modelling
Special Issues, Collections and Topics in MDPI journals
Dr. João Ribeiro

E-Mail Website
Guest Editor
Department of Mechanical Technology, School of Technology and Management, Polytechnic Institute of Bragança, Santa Apolónia Campus, 5300-253 Bragança, Portugal
Interests: prosthetic materials; design, control, and biomechanics of prosthesis; manufacturing processes of prosthesis
Special Issues, Collections and Topics in MDPI journals
Violeta Carvalho

E-Mail Website
Guest Editor Assistant
Department of Mechanical Engineering, University of Minho, 4800-058 Guimarães, Portugal
Interests: numerical modeling; hemodynamics; in vitro tests; biosensing; organ-on-a-chips
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Recently, microfluidic, nanofluidic, and lab-on-a-chip devices have gained particular attention in biomedical applications. Due to their advantages, such as miniaturization, versatility, ease of use, cost-effectiveness, and the potential to replace animal models for drug development and testing, these devices hold tremendous potential to revolutionize the research on more effective treatments for several diseases that threaten human life. With integrated biosensors, these devices allow the development and design of micro- and nanoparticles to be studied in detail, modelling human physiology, investigating the molecular and cellular mechanisms underlying disease formation and progression, and gaining insights into the performance and long-term effects of responsive drug delivery nanocarriers.

Given the success of the first edition of this Special Issue, a second volume was launched, seeking to gather high-quality research papers and review articles focusing on novel microfluidic, nanofluidic, and lab-on-a-chip devices for biomedical applications and addressing all steps related to the fabrication, biosensor integration and development, characterization, numerical simulations and validation of the devices, optimization and, if possible, the translation of these devices from research labs to industry settings.

We look forward to receiving your submissions.

Dr. Senhorinha Teixeira
Dr. João Eduardo P. Castro Ribeiro
Guest Editors
Dr. Violeta Carvalho
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • micro- and nanofluidics
  • lab-on-a-chip
  • biosensing
  • nanoparticles
  • drug delivery systems
  • 3D organ models
  • nanotechnology
  • numerical simulations

Related Special Issue

Published Papers (2 papers)

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Research

13 pages, 4578 KiB  
Article
Graphene Oxide Paper Manipulation of Micro-Reactor Drops
by Zhixiong Song, Eric Shen Lin, Md Hemayet Uddin, Hassan Ali Abid, Jian Wern Ong and Tuck Wah Ng
Micromachines 2023, 14(7), 1306; https://doi.org/10.3390/mi14071306 - 26 Jun 2023
Viewed by 952
Abstract
Digital microfluidics, which relies on the movement of drops, is relatively immune to clogging problems, making it suited for micro-reactor applications. Here, graphene oxide paper of 100 μm thickness, fabricated by blade coating sedimented dispersions onto roughened substrates, followed by drying and mechanical [...] Read more.
Digital microfluidics, which relies on the movement of drops, is relatively immune to clogging problems, making it suited for micro-reactor applications. Here, graphene oxide paper of 100 μm thickness, fabricated by blade coating sedimented dispersions onto roughened substrates, followed by drying and mechanical exfoliation, was found to be relatively free of cracks and curling. It also exhibited high wettability and elasto-capillary characteristics. Possessing low enough stiffness, it could rapidly and totally self-wrap water drops of 20 μL volume placed 2 mm from its edge when oriented between 0 and 60° to the horizontal. This complete wrapping behavior allowed drops to be translated via movement of the paper over long distances without dislodgement notwithstanding accelerations and decelerations. An amount of 2 drops that were wrapped with separate papers, when collided with each other at speeds up to 0.64 m/s, were found to eschew coalescence. This portends the development of robust digital microfluidic approaches for micro-reactors. Full article
(This article belongs to the Special Issue Micro/Nanofluidic and Lab-on-a-Chip Devices for Biomedical Applications, 2nd Edition)
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18 pages, 5514 KiB  
Article
Continuous Submicron Particle Separation Via Vortex-Enhanced Ionic Concentration Polarization: A Numerical Investigation
by Rasool Dezhkam, Hoseyn A. Amiri, David J. Collins and Morteza Miansari
Micromachines 2022, 13(12), 2203; https://doi.org/10.3390/mi13122203 - 12 Dec 2022
Cited by 5 | Viewed by 1703
Abstract
Separation and isolation of suspended submicron particles is fundamental to a wide range of applications, including desalination, chemical processing, and medical diagnostics. Ion concentration polarization (ICP), an electrokinetic phenomenon in micro-nano interfaces, has gained attention due to its unique ability to manipulate molecules [...] Read more.
Separation and isolation of suspended submicron particles is fundamental to a wide range of applications, including desalination, chemical processing, and medical diagnostics. Ion concentration polarization (ICP), an electrokinetic phenomenon in micro-nano interfaces, has gained attention due to its unique ability to manipulate molecules or particles in suspension and solution. Less well understood, though, is the ability of this phenomenon to generate circulatory fluid flow, and how this enables and enhances continuous particle capture. Here, we perform a comprehensive study of a low-voltage ICP, demonstrating a new electrokinetic method for extracting submicron particles via flow-enhanced particle redirection. To do so, a 2D-FEM model solves the Poisson–Nernst–Planck equation coupled with the Navier–Stokes and continuity equations. Four distinct operational modes (Allowed, Blocked, Captured, and Dodged) were recognized as a function of the particle’s charges and sizes, resulting in the capture or release from ICP-induced vortices, with the critical particle dimensions determined by appropriately tuning inlet flow rates (200–800 [µm/s]) and applied voltages (0–2.5 [V]). It is found that vortices are generated above a non-dimensional ICP-induced velocity of U*=1, which represents an equilibrium between ICP velocity and lateral flow velocity. It was also found that in the case of multi-target separation, the surface charge of the particle, rather than a particle’s size, is the primary determinant of particle trajectory. These findings contribute to a better understanding of ICP-based particle separation and isolation, as well as laying the foundations for the rational design and optimization of ICP-based sorting systems. Full article
(This article belongs to the Special Issue Micro/Nanofluidic and Lab-on-a-Chip Devices for Biomedical Applications, 2nd Edition)
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