Microdevices for Disease Diagnosis and Monitoring via Electrokinetics

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "B:Biology and Biomedicine".

Deadline for manuscript submissions: closed (20 December 2021) | Viewed by 2723

Special Issue Editors


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Guest Editor
Department of Chemical and Biomedical Engineering, West Virginia University, 1306 Evansdale Dr., P.O. Box 6102, Morgantown, WV 26506-6102, USA
Interests: microfluidics; bioseparations; dielectrophoresis; modeling and simulations; educational research
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Guest Editor
Department of Chemical Engineering, Michigan Technological University, Houghton, MI 49931, USA
Interests: medical microdevices; blood cell dynamics; point-of-care diagnostics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The manuscripts will be published as a collection of papers focusing on Microdevices for Disease Diagnosis and Monitoring via electrokinetics. Dielectrophoresis (DEP) remains an effective technique for rapid and label-free identification of targeted bioparticles. Applications are numerous, ranging from clinical diagnostics and therapeutics to advanced manufacturing. This Special Issue emphasizes on applications towards disease diagnostics that utilizes electrokinetics to manipulate and characterize infected bioparticles ranging from cells to proteins. Submissions integrating modeling and experimentation are preferred.

The contribution may be (i) a research article with original results, or (ii) a critical review, which may also contain original results focusing on novel methodological developments and applications pertaining to disease diagnostics in micro and sub-micro scale. The particular subjects of the upcoming issue focus on disease diagnosis using any of these technologies listed below on a microfluidic platform:

-Electrokinetics in microchannels and nanochannels;
-Traveling wave dielectrophoresis;
-Dielectrophoretic separation and manipulation.

Dr. Soumya Srivastava
Prof. Dr. Adrienne Minerick
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Research

14 pages, 5563 KiB  
Article
Dynamic pH and Thermal Analysis of Paper-Based Microchip Electrophoresis
by Muhammad Noman Hasan, Ran An, Asya Akkus, Derya Akkaynak, Adrienne R. Minerick, Chirag R. Kharangate and Umut A. Gurkan
Micromachines 2021, 12(11), 1433; https://doi.org/10.3390/mi12111433 - 22 Nov 2021
Cited by 6 | Viewed by 2160
Abstract
Paper-based microchip electrophoresis has the potential to bring laboratory electrophoresis tests to the point of need. However, high electric potential and current values induce pH and temperature shifts, which may affect biomolecule electrophoretic mobility thus decrease test reproducibility and accuracy of paper-based microfluidic [...] Read more.
Paper-based microchip electrophoresis has the potential to bring laboratory electrophoresis tests to the point of need. However, high electric potential and current values induce pH and temperature shifts, which may affect biomolecule electrophoretic mobility thus decrease test reproducibility and accuracy of paper-based microfluidic electrophoresis. We have previously developed a microchip electrophoresis system, HemeChip, which has the capability of providing low-cost, rapid, reproducible, and accurate point-of-care (POC) electrophoresis tests for hemoglobin analysis. Here, we report the methodologies we implemented for characterizing HemeChip system pH and temperature during the development process, including utilizing commercially available universal pH indicator and digital camera pH shift characterization, and infrared camera characterizing temperature shift characterization. The characterization results demonstrated that pH shifts up to 1.1 units, a pH gradient up to 0.11 units/mm, temperature shifts up to 40 °C, and a temperature gradient up to 0.5 °C/mm existed in the system. Finally, we report an acid pre-treatment of the separation media, a cellulose acetate paper, mitigated both pH and temperature shifts and provided a stable environment for reproducible HemeChip hemoglobin electrophoresis separation. Full article
(This article belongs to the Special Issue Microdevices for Disease Diagnosis and Monitoring via Electrokinetics)
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