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Micromachines
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Electrical Manipulation of Bioparticles in Microfluidics
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Electrical Manipulation of Bioparticles in Microfluidics

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "B：Biology and Biomedicine".

Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 3855

Special Issue Editor

Dr. Soumya Srivastava

E-Mail Website
Guest Editor
Department of Chemical and Biomedical Engineering, West Virginia University, 1306 Evansdale Dr., P.O. Box 6102, Morgantown, WV 26506-6102, USA
Interests: microfluidics; bioseparations; dielectrophoresis; modeling and simulations; educational research
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Microfluidics has shown its value in the application of bioparticle sorting for biology and medicine, such as the isolation of pathogens, proteins, exosomes, stem cells, and circulating tumor cells; blood-cell sorting; and cancer stem-cell separation. Electric and electrochemical approaches, including electrophoresis, dielectrophoresis (DEP), and electrowetting-on-dielectric (EWOD), are widely used for these applications. This Special Issue aims to focus on applications in the field of disease diagnostics that utilize electrokinetics to manipulate and characterize infected bioparticles ranging from cells to proteins. Submissions integrating modeling and experimentation are preferred.

Contributions may be (i) research articles with original results or (ii) critical reviews, which may also contain original results focusing on novel methodological developments and applications pertaining to the electrical manipulation of bioparticles at micro and sub-micro scales. The subjects of the upcoming issue could include, but are not limited to:

  • Electrokinetics in microchannels and nanochannels;
  • Dielectric spectroscopy;
  • Traveling wave dielectrophoresis;
  • Dielectrophoretic enrichment, separation, and manipulation;
  • Organ-on-a-chip with electrical stimulations;
  • Biosensors integrated with microchips utilizing an electric field to manipulate bioparticles;
  • AI/ML applications with microchips utilizing an electric field to manipulate bioparticles.

Dr. Soumya Srivastava
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • microfluidics
  • electrical gradient
  • bioparticles
  • dielectric spectroscopy

Published Papers (2 papers)

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Research

13 pages, 1858 KiB  
Article
Changes in Electrical Capacitance of Cell Membrane Reflect Drug Partitioning-Induced Alterations in Lipid Bilayer
by Shide Bakhtiari, Mohammad K. D. Manshadi, Mehmet Candas and Ali Beskok
Micromachines 2023, 14(2), 316; https://doi.org/10.3390/mi14020316 - 26 Jan 2023
Cited by 5 | Viewed by 2037
Abstract
The plasma membrane is a lipid bilayer that establishes the outer boundary of a living cell. The composition of the lipid bilayer influences the membrane’s biophysical properties, including fluidity, thickness, permeability, phase behavior, charge, elasticity, and formation of flat sheet or curved structures. [...] Read more.
The plasma membrane is a lipid bilayer that establishes the outer boundary of a living cell. The composition of the lipid bilayer influences the membrane’s biophysical properties, including fluidity, thickness, permeability, phase behavior, charge, elasticity, and formation of flat sheet or curved structures. Changes in the biophysical properties of the membrane can be occasioned when new entities, such as drug molecules, are partitioned in the bilayer. Therefore, assessing drugs for their effect on the biophysical properties of the lipid bilayer of a cell membrane is critical to understanding specific and non-specific drug action. Previously, we reported a non-invasive technique for real-time characterization of cellular dielectric properties, such as membrane capacitance and cytoplasmic conductivity. In this study, we discuss the potential application of the technique in assessing the biophysical properties of the cell membrane in response to interaction with amiodarone compared to aspirin/acetylsalicylic acid and glucose. Amiodarone is a potent drug used to treat cardiac arrhythmia, but it also exerts various non-specific effects. Compared to aspirin and glucose, we measured a rapid and higher magnitude increase in membrane capacitance on cells under amiodarone treatment. Increased membrane capacitance induced by aspirin and glucose quickly returned to baseline in 15 s, while amiodarone-induced increased capacitance sustained and decreased slowly, approaching baseline or another asymptotic limit in ~2.5 h. Because amiodarone has a strong lipid partitioning property, we reason that drug partitioning alters the lipid bilayer context and subsequently reduces bilayer thickness, leading to an increase in the electrical capacitance of the cell membrane. The presented microfluidic system promises a new approach to assess drug–membrane interactions and delineate specific and non-specific actions of the drug on cells. Full article
(This article belongs to the Special Issue Electrical Manipulation of Bioparticles in Microfluidics)
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13 pages, 3778 KiB  
Article
Comparative Study and Simulation of Capacitive Sensors in Microfluidic Channels for Sensitive Red Blood Cell Detection
by Wei Hu, Bingxing Wu, Soumya K. Srivastava and Suat Utku Ay
Micromachines 2022, 13(10), 1654; https://doi.org/10.3390/mi13101654 - 30 Sep 2022
Cited by 3 | Viewed by 1372
Abstract
Microfluidics provides an indispensable platform for combining analytical operations such as sample preparation, mixing, separation/enrichment, and detection onto a single compact platform, defined as a lab-on-a-chip (LOC) device with applicability in biomedical and life science applications. Due to its ease of integration, 1D [...] Read more.
Microfluidics provides an indispensable platform for combining analytical operations such as sample preparation, mixing, separation/enrichment, and detection onto a single compact platform, defined as a lab-on-a-chip (LOC) device with applicability in biomedical and life science applications. Due to its ease of integration, 1D interdigital capacitive (IDC) sensors have been used in microfluidic platforms to detect particles of interest. This paper presents a comparative study on the use of capacitive sensors for microfluidic devices to detect bioparticles, more specifically red blood cells (RBCs). The detection sensitivities of 1D, 2D, and 3D capacitive sensors were determined by simulation using COMSOL Multiphysics® v5.5. A water-filled 25 μm × 25 μm PDMS microfluidic channel was used with different sizes (5–10 μm) of red blood cells passing across the capacitive sensor regions. The conformal mapping was used for translating the 1D IDC sensor dimensions into equivalent 2D/3D parallel plate capacitance (PPC) sensor dimensions, creating similar absolute sensor capacitance. The detection sensitivity of each capacitive sensor is determined, and a new 3D PPC sensor structure was proposed to improve the sensitivity for high-resolution RBC detection in microfluidic channels. Proposed 2D and 3D sensors provide a 3× to 20× improvement in sensitivity compared to the standard 1D IDC structures, achieving a 100 aF capacitance difference when a healthy RBC passes in the structure. Full article
(This article belongs to the Special Issue Electrical Manipulation of Bioparticles in Microfluidics)
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