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Micromachines
Special Issues
Implantable Biocompatible Alloys Devices and Application
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Implantable Biocompatible Alloys Devices and Application

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "B：Biology and Biomedicine".

Deadline for manuscript submissions: closed (30 December 2022) | Viewed by 7992

Special Issue Editors

Prof. Dr. Petrica Vizureanu

E-Mail Website
Guest Editor
Faculty of Materials Science and Engineering, Gheorghe Asachi Technical University of Iasi, 41 D. Mangeron Street, 700050 Iasi, Romania
Interests: biomaterials; geoplymers; heat transfer; heat treatment; expert system; refractory materials; mine tailings
Special Issues, Collections and Topics in MDPI journals
Dr. Madalina Simona Baltatu

E-Mail Website
Guest Editor
Department of Technologies and Equipment for Materials Processing, Faculty of Materials Science and Engineering, Technical University Gheorghe Asachi of Iasi, 700050 Iasi, Romania
Interests: materials science; durability of materials in civil engineering; sustainable cementitious materials; metallic alloys; biomaterials; biodegradable alloys; biomaterials characterization; coatings and thin films
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues，

Globally, there is a continuing concern for the research and development of alloys for medical applications, with the ultimate goal of promoting a new generation of multifunctional implants with long-term performance.

This Special Issue will contain original high-quality research papers covering the most recent advances in implantable biocompatible alloys, as well as comprehensive reviews addressing the relevant state-of-the-art topics in the area of implantable biomaterials, with relevant practical applications.

The Special Issue “Implantable Biocompatible Alloys Devices and Application” will mainly cover the characterization of biocompatible materials focusing on the relevant or innovative medical applications of such an approach. 

In particular, the topics of interest include, but are not limited to:

  • Obtaining of all types of biomaterials used for medical applications: metallic, ceramics, polymers, composites;
  • Mechanical coating/alloying/treatment of the metallic and non-metallic materials;
  • Thermo/chemical treatment of the metallic and non-metallic materials.

In advanced, we would like to gratefully acknowledge the authors and reviewers who will participate in the elaboration of this Special Issue, who will contribute to the development of the biomaterials research.

Prof. Dr. Petrică Vizureanu
Dr. Simona Baltatu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomaterials
  • obtaining
  • characterization
  • coatings
  • treatments

Published Papers (3 papers)

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Research

15 pages, 8899 KiB  
Article
3D Printed Microfluidic Bioreactors Used for the Preferential Growth of Bacterial Biofilms through Dielectrophoresis
by Alexandra Csapai, Dan A. Toc, Florin Popa, Nicoleta Tosa, Violeta Pascalau, Carmen Costache, Alexandru Botan and Catalin O. Popa
Micromachines 2022, 13(9), 1377; https://doi.org/10.3390/mi13091377 - 24 Aug 2022
Cited by 6 | Viewed by 1700
Abstract
A realistic modelling of the way biofilms form and evolve in time requests a dynamic approach. In this study, the proposed route uses continuous-flow bioreactors under controlled flow rates and temperature in the culture medium containing bacteria or fungi. 3D printed, Polylactic acid [...] Read more.
A realistic modelling of the way biofilms form and evolve in time requests a dynamic approach. In this study, the proposed route uses continuous-flow bioreactors under controlled flow rates and temperature in the culture medium containing bacteria or fungi. 3D printed, Polylactic acid (PLA), flow-based bioreactors with integrated copper electrodes were used to investigate the effect of dielectrophoresis on the formation and growth of Staphylococcus aureus ATCC 25923, Enterococcus faecalis ATCC 29212, Pseudomonas aeruginosa ATCC 27853, and Klebsiella pneumoniae ATCC 13883 biofilms. Bacterial suspensions of 1McF turbidity have been prepared and circulated through the bioreactors. At the same time, a 30 V potential difference was applied on the system. The effect of the non-uniform electric field induced upon the bacterial cells was determined using quantitative methods, such as an adjusted microtiter plate technique, as well as spectral domain optical coherence tomography (SD-OCT) images. The morphology and the surface quality of the biofilms were investigated using Scanning Electron Microscopy (SEM) images. The results show that the different bacterial cells present a positive dielectrophoretic behaviour, with the preferential formation of biofilms in the high field gradient region. Full article
(This article belongs to the Special Issue Implantable Biocompatible Alloys Devices and Application)
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12 pages, 5165 KiB  
Article
Mechanical Characterization and In Vitro Assay of Biocompatible Titanium Alloys
by Iustinian Baltatu, Andrei Victor Sandu, Maria Daniela Vlad, Mihaela Claudia Spataru, Petrica Vizureanu and Madalina Simona Baltatu
Micromachines 2022, 13(3), 430; https://doi.org/10.3390/mi13030430 - 10 Mar 2022
Cited by 17 | Viewed by 2107
Abstract
Metals that come into contact with the body can cause reactions in the body, so biomaterials must be tested to avoid side effects. Mo, Zr, and Ta are non-toxic elements; alloyed with titanium, they have very good biocompatibility properties and mechanical properties. The [...] Read more.
Metals that come into contact with the body can cause reactions in the body, so biomaterials must be tested to avoid side effects. Mo, Zr, and Ta are non-toxic elements; alloyed with titanium, they have very good biocompatibility properties and mechanical properties. The paper aims to study an original Ti20Mo7ZrxTa system (5, 10, 15 wt %) from a mechanical and in vitro biocompatibility point of view. Alloys were examined by optical microstructure, tensile strength, fractographic analysis, and in vitro assay. The obtained results indicate very good mechanical and biological properties, recommending them for future orthopedic medical applications. Full article
(This article belongs to the Special Issue Implantable Biocompatible Alloys Devices and Application)
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12 pages, 3237 KiB  
Article
Biomimetic Deposition of Hydroxyapatite Layer on Titanium Alloys
by Madalina Simona Baltatu, Andrei Victor Sandu, Marcin Nabialek, Petrica Vizureanu and Gabriela Ciobanu
Micromachines 2021, 12(12), 1447; https://doi.org/10.3390/mi12121447 - 25 Nov 2021
Cited by 23 | Viewed by 1860
Abstract
Over the last decade, researchers have been concerned with improving metallic biomaterials with proper and suitable properties for the human body. Ti-based alloys are widely used in the medical field for their good mechanical properties, corrosion resistance and biocompatibility. The TiMoZrTa system (TMZT) [...] Read more.
Over the last decade, researchers have been concerned with improving metallic biomaterials with proper and suitable properties for the human body. Ti-based alloys are widely used in the medical field for their good mechanical properties, corrosion resistance and biocompatibility. The TiMoZrTa system (TMZT) evidenced adequate mechanical properties, was closer to the human bone, and had a good biocompatibility. In order to highlight the osseointegration of the implants, a layer of hydroxyapatite (HA) was deposited using a biomimetic method, which simulates the natural growth of the bone. The coatings were examined by scanning electron microscopy (SEM), X-ray diffraction (XRD), micro indentation tests and contact angle. The data obtained show that the layer deposited on TiMoZrTa (TMZT) support is hydroxyapatite. Modifying the surface of titanium alloys represents a viable solution for increasing the osseointegration of materials used as implants. The studied coatings demonstrate a positive potential for use as dental and orthopedic implants. Full article
(This article belongs to the Special Issue Implantable Biocompatible Alloys Devices and Application)
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