Nanostructured Surfaces in Metallic Biomaterials

A special issue of Metals (ISSN 2075-4701).

Deadline for manuscript submissions: closed (30 September 2018) | Viewed by 3788

Special Issue Editor


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Guest Editor
Institute of Materials Science and Engineering, Poznan University of Technology, M.Sklodowska-Curie 5 Sq., 60-965 Poznan, Poland
Interests: nanostructured materials; non-equilibrium processing and properties of advanced materials/nanomaterials; microstructural characterization; powder processing; composites/nanocomposites; porous metallic bionanomaterials/bionanocomposites; hydrogen storage materials/nanomaterials
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Special Issue Information

Dear Colleagues,

Over the past few years, nanomaterials have become very popular in medical applications. The enhancement of bone formation, at the bone–implant interface, has been achieved through the modulation of osteoblast adhesion and spreading, induced by modifications at the nanoscale level of implant surfaces.

Titanium and titanium alloys are preferred materials in the production of implants. Currently, titanium and its alloys are used for dentistry devices, such as implants, crowns, bridges, overdentures, and dental implant prosthesis components (screw and abutment).

Current research focuses on improving the mechanical performance and biocompatibility of Ti-based systems through variations in alloy composition, microstructure and surface treatment. In the case of titanium, significant efforts go into enhancing the strength characteristics of commercial purity grades to avoid potential biotoxicity of alloying elements.

Recent studies have clearly proved that nanostructuring of titanium can considerably improve, not only mechanical properties, but also biocompatibility. This approach also has the benefit of enhancing the biological response of the cp titanium surface. For providing fast osseointegration and long-term usage in the human body, the implant surface should be modified, i.e., it should be rough or porous, oxidized, and covered by a biocompatible coating, including calcium–phosphate compounds. Surfaces showing, micro- and nano-irregularities are useful in biocompatibility improvements.

This Special Issue aims to present the latest research related to nanostructured surfaces in metallic biomaterials. Research reports associated with the manufacture techniques and the related cells-surface interactions and modulation, as well as modifications of implant surfaces at the nanometric level are also welcome.

Prof. Dr. Mieczyslaw Jurczyk
Guest Editor

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Keywords

  • metallic biomaterials
  • titanium
  • nanotechnologies
  • surfaces
  • roughness
  • cell proliferation
  • differentiation
  • osteogenesis
  • implant

Published Papers (1 paper)

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Research

2654 KiB  
Article
Preparation of Chitosan/Poly‐γ‐Glutamic Acid Polyelectrolyte Multilayers on Biomedical Metals for Local Antibiotic Delivery
by Wai-Ching Liu, Huey-Yuan Wang, An-Ni Wang, Chih-Hsien Tseng, Hsuan-Liang Liu and Ren-Jei Chung
Metals 2017, 7(10), 418; https://doi.org/10.3390/met7100418 - 07 Oct 2017
Cited by 5 | Viewed by 3423
Abstract
Polyelectrolyte multilayer assembly is one of the most widely applied biomaterial coatings for applications from surface modification, drug delivery, tissue engineering to biomimetic extracellular environment. In this research, we propose a simple layer-wise spin coating technique to prepare chitosan/poly-γ-glutamic acid (C/PGA) polyelectrolyte multilayers [...] Read more.
Polyelectrolyte multilayer assembly is one of the most widely applied biomaterial coatings for applications from surface modification, drug delivery, tissue engineering to biomimetic extracellular environment. In this research, we propose a simple layer-wise spin coating technique to prepare chitosan/poly-γ-glutamic acid (C/PGA) polyelectrolyte multilayers (PEMs) on two different biomedical metals, 316L stainless steel (316LSS) and titanium alloy (Ti6Al4V). The multilayer coating was fabricated using oppositely charged chitosan and poly--glutamic acid to deposit a total of 10, 20, or 30 multilayered films. Afterward, tetracycline was loaded by soaking the coated metals for 12 hours. The microstructure, mechanical properties, biocompatibility and drug release rate were investigated by scanning electron microscopy, contact angle measurement, MG63 cell viability and inhibition of Escherichia coli (E. coli) growth. Lastly, MG63 cell attachment was detected by fluorescence microscopy after staining with Hoechst 33258. This coating technique can prepare a layer of 2.2–6.9 m C/PGA PEMs favoring cell attachment and growth. Moreover, tetracycline was released from C/PGA PEMs and inhibited the growth of E. coli. The results suggest that C/PGA PEMs provide a useful platform for modulating the micro-environment for better cell adhesion and antibiotic delivery, which hold great potential for surface modification and drug loading for biomimetic materials. Full article
(This article belongs to the Special Issue Nanostructured Surfaces in Metallic Biomaterials)
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