Strategies and Concepts of Extracorporeal Life Support (ECLS)

A special issue of Membranes (ISSN 2077-0375). This special issue belongs to the section "Membrane Applications".

Deadline for manuscript submissions: closed (30 November 2021) | Viewed by 2801

Special Issue Editors


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Guest Editor
Department of Cardiac Surgery, Medical University of Vienna, 1090 Vienna, Austria
Interests: extracorporeal membrane oxygenation (ECMO); mechanical circulatory support (MCS); ventricular assist devices (VAD); minimally invasive cardiac surgery; pediatric cardiac surgery
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Co-Guest Editor
Department of internal Medicine II, Division of Cardiology, Medical University of Vienna, 10090 Vienna, Austria
Interests: cardiology; ECMO therapy

E-Mail Website
Co-Guest Editor
Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, 1090 Vienna, Austria
Interests: cardiology; ECMO therapy

Special Issue Information

Dear Colleagues,

Extracorporeal life support (ECLS) is a technique for cardiac and/or pulmonary support if other more conservative measures are not able to sustain an adequate perfusion and/or gas exchange. Largely derived from cardiopulmonary bypass, the technique was developed during the early 1970s. However, after the initial enthusiasm, ECLS was regarded as useless or as an experimental method just to delay death, but not as a true treatment modality. Technological evolution together with improvements in the management of ECLS patients has led to significantly better outcomes and wider adoption of the technique. Nowadays, ECLS is used for the treatment of a broad variety of cardiac and/or pulmonary diseases, either with the target to recover the respective organs or as a bridge to organ transplantation or durable mechanical circulatory support. Despite all the improvements, the outcome after ECLS is still limited, and this is partly related to the patient’s critical status but also to the associated complications. The scientific literature on this topic is scarce, and thus this Special Issue aims to collect clinical reports, experimental data, and reviews on new strategies and concepts of ECLS in order to increase the knowledge and acceptance of this therapy within the medical community.

Dr. Dominik Wiedemann
Dr. George Goliasch
Dr. Klaus Distelmaier
Guest Editors

Manuscript Submission Information

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Keywords

  • Extracorporeal life support (ECLS)
  • Extracorporeal membrane oxygenation (ECMO)
  • Mechanical circulatory support
  • Post cardiotomy ECLS
  • Heart failure
  • Respiratory failure

Published Papers (1 paper)

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Research

14 pages, 839 KiB  
Article
Comparisons of Outcomes between Patients with Direct and Indirect Acute Respiratory Distress Syndrome Receiving Extracorporeal Membrane Oxygenation
by Li-Chung Chiu, Li-Pang Chuang, Shih-Wei Lin, Hsin-Hsien Li, Shaw-Woei Leu, Ko-Wei Chang, Chi-Hsien Huang, Tzu-Hsuan Chiu, Huang-Pin Wu, Feng-Chun Tsai, Chung-Chi Huang, Han-Chung Hu and Kuo-Chin Kao
Membranes 2021, 11(8), 644; https://doi.org/10.3390/membranes11080644 - 22 Aug 2021
Cited by 3 | Viewed by 2236
Abstract
Acute respiratory distress syndrome (ARDS) is a heterogeneous syndrome caused by direct (local damage to lung parenchyma) or indirect lung injury (insults from extrapulmonary sites with acute systemic inflammatory response), the clinical and biological complexity can have a profound effect on clinical outcomes. [...] Read more.
Acute respiratory distress syndrome (ARDS) is a heterogeneous syndrome caused by direct (local damage to lung parenchyma) or indirect lung injury (insults from extrapulmonary sites with acute systemic inflammatory response), the clinical and biological complexity can have a profound effect on clinical outcomes. We performed a retrospective analysis of 152 severe ARDS patients receiving extracorporeal membrane oxygenation (ECMO). Our objective was to assess the differences in clinical characteristics and outcomes of direct and indirect ARDS patients receiving ECMO. Overall hospital mortality was 53.3%. A total of 118 patients were assigned to the direct ARDS group, and 34 patients were assigned to the indirect ARDS group. The 28-, 60-, and 90-day hospital mortality rates were significantly higher among indirect ARDS patients (all p < 0.05). Cox regression models demonstrated that among direct ARDS patients, diabetes mellitus, immunocompromised status, ARDS duration before ECMO, and SOFA score during the first 3 days of ECMO were independently associated with mortality. In indirect ARDS patients, SOFA score and dynamic compliance during the first 3 days of ECMO were independently associated with mortality. Our findings revealed that among patients receiving ECMO, direct and indirect subphenotypes of ARDS have distinct clinical outcomes and different predictors for mortality. Full article
(This article belongs to the Special Issue Strategies and Concepts of Extracorporeal Life Support (ECLS))
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