Statistical Methods in Bioinformatics and Health Informatics

A special issue of Mathematics (ISSN 2227-7390). This special issue belongs to the section "Probability and Statistics".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 1287

Special Issue Editor


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Guest Editor
Department of Biostatistics, University of Nebraska Medical Center, Omaha, NE, USA
Interests: causal inference; measurement error modeling; biomarker evaluation; metabolomics; nutritional epidemiology; risk of chronic diseases
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

It is our pleasure to invite you to submit a paper to our upcoming Special Issue on "Statistical Methods in Bioinformatics and Health Informatics". We aim to feature original research articles, reviews, and perspectives that focus on the development and application of sophisticated statistical and machine learning methods to analyze bioinformatics and health informatics data, including, but not limited to, genomics, transcriptomics, proteomics, metabolomics, microbiomics, radiomics, and electronic health record data.

This Special Issue will highlight recent advancements in statistical methods and their applications in bioinformatics and health informatics data. We welcome submissions that cover a wide range of topics, such as:

  • Dimension reduction and feature selection methods;
  • Machine learning and artificial intelligence method;
  • Federated or distributional learning to handle big data;
  • The early diagnosis of disease and prediction of treatment response utilizing high-dimensional biomarkers;
  • Precision medicine using omics data;
  • The integration of multi-omics data.

We hope that this Special Issue will provide a platform for researchers from various disciplines to share their latest findings, discuss emerging challenges, and propose novel solutions.

We look forward to your contribution and participation.

Dr. Cheng Zheng
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Mathematics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioinformatics
  • precision medicine
  • health informatics
  • big data
  • electronic health records
  • artificial intelligence
  • highly dimensional data
  • machine learning
  • distributed learning
  • federated learning
  • online learning
  • genomics
  • transcriptomics
  • proteomics
  • metabolomics
  • radiomics
  • microbiomics
  • computational biology

Published Papers (1 paper)

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Research

11 pages, 451 KiB  
Article
High-Dimensional Mediation Analysis for Time-to-Event Outcomes with Additive Hazards Model
by Meng An and Haixiang Zhang
Mathematics 2023, 11(24), 4891; https://doi.org/10.3390/math11244891 - 06 Dec 2023
Viewed by 1020
Abstract
Mediation analysis plays an increasingly crucial role in identifying potential causal pathways between exposures and outcomes. However, there is currently a lack of developed mediation approaches for high-dimensional survival data, particularly when considering additive hazard models. The present study introduces two novel approaches [...] Read more.
Mediation analysis plays an increasingly crucial role in identifying potential causal pathways between exposures and outcomes. However, there is currently a lack of developed mediation approaches for high-dimensional survival data, particularly when considering additive hazard models. The present study introduces two novel approaches for identifying statistically significant mediators in high-dimensional additive hazard models, including the multiple testing-based mediator selection method and knockoff filter procedure. The simulation results demonstrate the outstanding performance of these two proposed methods. Finally, we employ the proposed methodology to analyze the Cancer Genome Atlas (TCGA) cohort in order to identify DNA methylation markers that mediate the association between smoking and survival time among lung cancer patients. Full article
(This article belongs to the Special Issue Statistical Methods in Bioinformatics and Health Informatics)
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