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Delivery Nanomaterials for Cancer Therapy

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Advanced Nanomaterials and Nanotechnology".

Deadline for manuscript submissions: closed (10 March 2023) | Viewed by 3389

Special Issue Editors


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Guest Editor
Institute of Microbiology, Czech Academy of Sciences, Videnska 1083, 140 00 Prague 4, Czech Republic
Interests: nanomaterial; gene therapy; gene expression; drug delivery; cell transfection

E-Mail Website
Guest Editor
Institute of Microbiology, Czech Academy of Sciences, Videnska 1083, 140 00 Prague 4, Czech Republic
Interests: biologically produced nanoparticles; gene therapy; drug delivery; wound healing

Special Issue Information

Dear Colleagues,

Nanomaterial use in biomedicine has grown extensively in recent decades. Particular focus has been devoted to nanoparticles as drug delivery systems in cancer treatment as nanosized drug carriers possess specific advantages when compared to conventional drugs. Namely, conjugation of conventional drugs with nanocarriers improves drug stability and biocompatibility. Furthermore, it promotes drug accumulation due to better enhanced permeability and retention effect. Importantly, it allows cancer cell targeting and helps to overcome drug resistance.

Although there is still a little bit of uncertainty in the use of nanocarriers in human cancer treatment, we believe in their success. This uncertainty is mostly based on the heterogenic, often unpredictable behavior of various nanomaterials. Since each nanomaterial possesses advantages and disadvantages, researchers tend to define the specific conditions of use for a particular nanomaterial (mainly the size, shape, preparation method, charge, and coating). A big step ahead has been the development of nanocarriers consisting of different nanoparticles, boosting the performance of the final drug carrier.

In this Special Issue, we plan to gather representative delivery approaches based on different nanomaterials, including hybrid structures with the final aim to target cancer cells. We expect contributions based on basic science as well as translational research in the fields of biological and biochemical experimentation as well as material research.

Dr. Veronika Benson
Dr. Parastoo Pourali
Guest Editors

Manuscript Submission Information

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Keywords

  • nanomaterial
  • cancer therapy
  • drug delivery
  • cancer targeting
  • nanocarriers

Published Papers (2 papers)

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Research

9 pages, 1776 KiB  
Article
Enhanced Design of Gold Catalysts for Bioorthogonal Polyzymes
by Cristina-Maria Hirschbiegel, Stefano Fedeli, Xianzhi Zhang, Rui Huang, Jungmi Park, Yisheng Xu and Vincent M. Rotello
Materials 2022, 15(18), 6487; https://doi.org/10.3390/ma15186487 - 19 Sep 2022
Cited by 7 | Viewed by 2235
Abstract
Bioorthogonal chemistry introduces nonbiogenic reactions that can be performed in biological systems, allowing for the localized release of therapeutic agents. Bioorthogonal catalysts can amplify uncaging reactions for the in situ generation of therapeutics. Embedding these catalysts into a polymeric nanoscaffold can protect and [...] Read more.
Bioorthogonal chemistry introduces nonbiogenic reactions that can be performed in biological systems, allowing for the localized release of therapeutic agents. Bioorthogonal catalysts can amplify uncaging reactions for the in situ generation of therapeutics. Embedding these catalysts into a polymeric nanoscaffold can protect and modulate the catalytic activity, improving the performance of the resulting bioorthogonal “polyzymes”. Catalysts based on nontoxic metals such as gold(I) are particularly attractive for therapeutic applications. Herein, we optimized the structural components of a metal catalyst to develop an efficient gold(I)-based polyzyme. Tailoring the ligand structure of gold phosphine-based complexes, we improved the affinity between the metal complex and polymer scaffold, resulting in enhanced encapsulation efficiency and catalytic rate of the polyzyme. Our findings show the dependence of the overall polyzyme properties on the structural properties of the encapsulated metal complex. Full article
(This article belongs to the Special Issue Delivery Nanomaterials for Cancer Therapy)
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22 pages, 6774 KiB  
Article
Investigation of Protein Corona Formed around Biologically Produced Gold Nanoparticles
by Parastoo Pourali, Eva Neuhöferová, Volha Dzmitruk and Veronika Benson
Materials 2022, 15(13), 4615; https://doi.org/10.3390/ma15134615 - 30 Jun 2022
Cited by 5 | Viewed by 1613
Abstract
Although there are several research articles on the detection and characterization of protein corona on the surface of various nanoparticles, there are no detailed studies on the formation, detection, and characterization of protein corona on the surface of biologically produced gold nanoparticles (AuNPs). [...] Read more.
Although there are several research articles on the detection and characterization of protein corona on the surface of various nanoparticles, there are no detailed studies on the formation, detection, and characterization of protein corona on the surface of biologically produced gold nanoparticles (AuNPs). AuNPs were prepared from Fusarium oxysporum at two different temperatures and characterized by spectrophotometry, Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), and energy-dispersive X-ray spectroscopy (EDS). The zeta potential of AuNPs was determined using a Zetasizer. AuNPs were incubated with 3 different concentrations of mouse plasma, and the hard protein corona was detected first by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and then by electrospray liquid chromatography–mass spectrometry (LC-MS). The profiles were compared to AuNPs alone that served as control. The results showed that round and oval AuNPs with sizes below 50 nm were produced at both temperatures. The AuNPs were stable after the formation of the protein corona and had sizes larger than 86 nm, and their zeta potential remained negative. We found that capping agents in the control samples contained small peptides/amino acids but almost no protein(s). After hard protein corona formation, we identified plasma proteins present on the surface of AuNPs. The identified plasma proteins may contribute to the AuNPs being shielded from phagocytizing immune cells, which makes the AuNPs a promising candidate for in vivo drug delivery. The protein corona on the surface of biologically produced AuNPs differed depending on the capping agents of the individual AuNP samples and the plasma concentration. Full article
(This article belongs to the Special Issue Delivery Nanomaterials for Cancer Therapy)
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