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Bioactive Compounds and Complexes: Synthesis, Structural and Physicochemical Studies
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Bioactive Compounds and Complexes: Synthesis, Structural and Physicochemical Studies

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Materials Chemistry".

Deadline for manuscript submissions: closed (31 October 2021) | Viewed by 7935

Special Issue Editors

Dr. Liliana Mazur

E-Mail Website
Guest Editor
Institute of Chemical Sciences, Faculty of Chemistry, Maria Curie-Sklodowska University, pl. M. Curie-Skłodowskiej 2, 20-031 Lublin, Poland
Interests: structural chemistry; crystal engineering; intermolecular interactions; polymorphism; co-crystals; transition metal complexes with bioactive ligands, mechanochemistry
Dr. Katarzyna Jarzembska

E-Mail Website
Guest Editor
Department of Chemistry, University of Warsaw, Żwirki i Wigury 101, 02-089 Warsaw, Poland
Interests: photocrystallography; time-resolved X-ray diffraction; luminescent materials; crystal engineering, charge density studies, computational modelling

Special Issue Information

Dear Colleagues,

Drug resistance is a growing problem in the treatment of diseases caused by bacteria, viruses, fungi, and parasites. Infectious diseases, such as tuberculosis, malaria, dysentery, viral hepatitis, AIDS, and recently COVID-19, are global threats. Similarly, the steady increase in the incidence of cancer and neurodegenerative diseases constitutes a global issue. Therefore, searching for more effective, less toxic, and inexpensive chemotherapeutic agents is of greatest importance.

Although until recently the search for new biologically active molecules has been restricted predominantly to organic compounds, inorganic medicinal chemistry is nowadays one of the fastest growing research areas in the drug design field. The concept of medicinal inorganic chemistry has matured in the last 50 years, since the discovery of the anticancer activity of cisplatin by Rosenberg and coworkers. This result began a search for other transition metal coordination compounds with potential pharmaceutical applications. Properties of such systems, including lipophilicity, charge, shape, redox potential, chemical and thermodynamic stability can be effectively tuned via ligand variation and modifications. Therefore, strategic metal selection and rational ligand design offers control over kinetic and thermodynamic properties of the resulting compounds.

The current medicinal inorganic chemistry is focused on discovery and development of metallodrugs, in which the metal complex constitutes an active ingredient, as well as on the organic compounds that act on metal-containing biomolecules, or may have an effect on metabolism of the metal ions and on metal-dependent cellular processes. Another important area is the design of new diagnostic agents.

Hence, the studies dedicated to synthesis, structural, and physicochemical properties of new bioactive ligands and their metal complexes are relevant in regard to drug development, but they may also contribute to the rational design of novel metal-based therapeutic and diagnostic agents.

This Special Issue shall cover all aspects of modern inorganic medicinal chemistry, providing useful insights into the latest developments and future trends. Main topics include but are not limited to:

  • Innovative synthetic approaches towards sustainable metal-based therapeutics
  • Rational ligand design and selection both of natural and synthetic origin
  • Special chelating agents for medicinal use
  • Structural and physicochemical characterization of bioactive compounds
  • Biotransformation of metallic compounds
  • Transition metal catalysis and catalytic metallodrugs
  • Antioxidants, antidiabetic, and dementia relevant metallic systems
  • Biomarkers and light activated prodrugs

Authors are most welcome to submit their original work in the form of full papers, communications, or up-to-date reviews.

Dr. Liliana Mazur
Dr. Katarzyna Jarzembska
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • inorganic medicinal chemistry
  • structural properties of bioactive compounds
  • metal-ligand complex stability and specificity
  • therapeutic and diagnostic radiopharmaceuticals
  • metal-based antioxidants
  • catalytic metallodrugs

Published Papers (3 papers)

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Research

21 pages, 3176 KiB  
Article
Crystal Structure, Spectroscopic Characterization, Antioxidant and Cytotoxic Activity of New Mg(II) and Mn(II)/Na(I) Complexes of Isoferulic Acid
by Monika Kalinowska, Ewelina Gołębiewska, Liliana Mazur, Hanna Lewandowska, Marek Pruszyński, Grzegorz Świderski, Marta Wyrwas, Natalia Pawluczuk and Włodzimierz Lewandowski
Materials 2021, 14(12), 3236; https://doi.org/10.3390/ma14123236 - 11 Jun 2021
Cited by 11 | Viewed by 2924
Abstract
The Mg(II) and heterometallic Mn(II)/Na(I) complexes of isoferulic acid (3-hydroxy-4-methoxycinnamic acid, IFA) were synthesized and characterized by infrared spectroscopy FT-IR, FT-Raman, electronic absorption spectroscopy UV/VIS, and single-crystal X-ray diffraction. The reaction of MgCl2 with isoferulic acid in the aqueous solutions of NaOH [...] Read more.
The Mg(II) and heterometallic Mn(II)/Na(I) complexes of isoferulic acid (3-hydroxy-4-methoxycinnamic acid, IFA) were synthesized and characterized by infrared spectroscopy FT-IR, FT-Raman, electronic absorption spectroscopy UV/VIS, and single-crystal X-ray diffraction. The reaction of MgCl2 with isoferulic acid in the aqueous solutions of NaOH resulted in synthesis of the complex salt of the general formula of [Mg(H2O)6]⋅(C10H9O4)2⋅6H2O. The crystal structure of this compound consists of discrete octahedral [Mg(H2O)6]2+ cations, isoferulic acid anions and solvent water molecules. The hydrated metal cations are arranged among the organic layers. The multiple hydrogen-bonding interactions established between the coordinated and lattice water molecules and the functional groups of the ligand stabilize the 3D architecture of the crystal. The use of MnCl2 instead of MgCl2 led to the formation of the Mn(II)/Na(I) complex of the general formula [Mn3Na2(C10H7O4)8(H2O)8]. The compound is a 3D coordination polymer composed of centrosymmetric pentanuclear subunits. The antioxidant activity of these compounds was evaluated by assays based on different antioxidant mechanisms of action, i.e., with •OH, DPPH• and ABTS•+ radicals as well as CUPRAC (cupric ions reducing power) and lipid peroxidation inhibition assays. The pro-oxidant property of compounds was measured as the rate of oxidation of Trolox. The Mg(II) and Mn(II)/Na(I) complexes with isoferulic acid showed higher antioxidant activity than ligand alone in DPPH (IFA, IC50 = 365.27 μM, Mg(II) IFA IC50 = 153.50 μM, Mn(II)/Na(I) IFA IC50 = 149.00 μM) and CUPRAC assays (IFA 40.92 μM of Trolox, Mg(II) IFA 87.93 μM and Mn(II)/Na(I) IFA 105.85 μM of Trolox; for compounds’ concentration 10 μM). Mg(II) IFA is a better scavenger of •OH than IFA and Mn(II)/Na(I) IFA complex. There was no distinct difference in ABTS•+ and lipid peroxidation assays between isoferulic acid and its Mg(II) complex, while Mn(II)/Na(I) complex showed lower activity than these compounds. The tested complexes displayed only slight antiproliferative activity tested in HaCaT human immortalized keratinocyte cell line within the solubility range. The Mn(II)/Na(I) IFA (16 μM in medium) caused an 87% (±5%) decrease in cell viability, the Mg salt caused a comparable, i.e., 87% (±4%) viability decrease in a concentration of 45 μM, while IFA caused this level of cell activity attenuation (87% ± 5%) at the concentration of 1582 μM (significant at α = 0.05). Full article
(This article belongs to the Special Issue Bioactive Compounds and Complexes: Synthesis, Structural and Physicochemical Studies)
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13 pages, 526 KiB  
Article
Novel 2,4,6-Trimethylbenzenesulfonyl Hydrazones with Antibacterial Activity: Synthesis and In Vitro Study
by Łukasz Popiołek, Sylwia Szeremeta, Anna Biernasiuk and Monika Wujec
Materials 2021, 14(11), 2723; https://doi.org/10.3390/ma14112723 - 21 May 2021
Cited by 4 | Viewed by 1532
Abstract
This research describes the synthesis and in vitro antimicrobial activity study of a series of 2,4,6-trimethylbenzenesulfonyl hydrazones. Twenty-five hydrazones (2–26) were synthesized on the basis of condensation reaction. The in vitro bioactivity study confirmed the potential application of obtained [...] Read more.
This research describes the synthesis and in vitro antimicrobial activity study of a series of 2,4,6-trimethylbenzenesulfonyl hydrazones. Twenty-five hydrazones (2–26) were synthesized on the basis of condensation reaction. The in vitro bioactivity study confirmed the potential application of obtained derivatives as antimicrobial agents. Among the tested compounds, the highest activity was discovered for derivative 24, which possessed minimal inhibitory concentration (MIC) ranging from 7.81 to 15.62 µg/mL against Gram-positive reference bacterial strains. Synthesized benzenesulfonyl hydrazones can be applied as potential ligands for the synthesis of bioactive metal complexes. Full article
(This article belongs to the Special Issue Bioactive Compounds and Complexes: Synthesis, Structural and Physicochemical Studies)
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20 pages, 5961 KiB  
Article
Physical Properties, Spectroscopic, Microscopic, X-ray, and Chemometric Analysis of Starch Films Enriched with Selected Functional Additives
by Maciej Combrzyński, Tomasz Oniszczuk, Karol Kupryaniuk, Agnieszka Wójtowicz, Marcin Mitrus, Marek Milanowski, Jakub Soja, Iwona Budziak-Wieczorek, Dariusz Karcz, Daniel Kamiński, Sławomir Kulesza, Karolina Wojtunik-Kulesza, Kamila Kasprzak-Drozd, Marek Gancarz, Iwona Kowalska, Lidia Ślusarczyk and Arkadiusz Matwijczuk
Materials 2021, 14(10), 2673; https://doi.org/10.3390/ma14102673 - 20 May 2021
Cited by 14 | Viewed by 2826
Abstract
Biodegradable materials are used in the manufacture of packaging and compostable films and various types of medical products. They have demonstrated a large number of potential practical applications in medicine and particularly in the treatment of various cardiac, vascular, and orthopedic conditions in [...] Read more.
Biodegradable materials are used in the manufacture of packaging and compostable films and various types of medical products. They have demonstrated a large number of potential practical applications in medicine and particularly in the treatment of various cardiac, vascular, and orthopedic conditions in adults as well in children. In our research, the extrusion-cooking technique was applied to prepare thermoplastic starch (TPS), which was then utilized to obtain environmentally friendly starch-based films. Potato starch was the basic raw material exploited. Polyvinyl alcohol and keratin were used as functional additives in amounts from 0.5 to 3%, while 20% of glycerol was harnessed as a plasticizer. The processing of the thermoplastic starch employed a single screw extruder-cooker with an L/D ratio of 16. The film blowing process was carried out using a film-blowing laboratory line with L/D = 36. FTIR Spectroscopy was applied for the assignment of the prominent functional groups. The results showed that the processing efficiency of thermoplastic starch with functional additives varied depending on the level of polyvinyl alcohol and keratin addition. Moreover, the FTIR data correlated with the changes in the physical properties of the tested films. The analysis of FTIR spectra revealed several changes in the intensity of bands originating from stretching vibrations characteristic of the –OH substituent. The changes observed depended on the presence/lack of the hydrogen bonding occurring upon interactions between the starch molecules and the various additives used. In addition, notable changes were observed in bands assigned to glycoside bonds in the starch. Full article
(This article belongs to the Special Issue Bioactive Compounds and Complexes: Synthesis, Structural and Physicochemical Studies)
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