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Advanced Nanomaterials for Potential Use in Healthcare

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Dr. Anthony J. Di Pasqua

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Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, Binghamton University State University of New York, P.O. Box, 6000 Binghamton, NY 13902-6000, USA
Interests: chemo- and radio-therapeutics; nanomaterials and formulation

Special Issue Information

Dear colleagues,

As a scientific community, we strive to create and improve therapies to treat disease. If we can enhance the efficacy of a therapeutically-active compound by incorporating it into a biocompatible material and, at the same time, limit its toxicity, this is considered a success. However, the real success is getting such materials translated into the clinic. The ability of materials to target disease and control-release their cargo give healthcare providers the ability to improve compliance and health outcomes.

Nanomaterials have been an exciting type of material to explore, but to ensure that our work can move into the clinic, we need to ensure biocompatibility and the improved performance of therapies. Thus, I invite you my colleagues to submit an article for review and potential publication in this Special Issue of Materials entitled “Advanced Nanomaterials for Potential Use in Healthcare”. If your work is in the preparation and characterization of such materials and/or their use in cell or animal models, we would greatly appreciate this opportunity to spotlight your efforts in this area. Thank you.

Dr. Anthony J. Di Pasqua

Guest Editor

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Keywords

Nanomaterials
Drug delivery systems
Biocompatibility
Healthcare.

Published Papers (3 papers)

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Research

14 pages, 4079 KiB

Open AccessArticle

Physicochemical Factors That Influence the Biocompatibility of Cationic Liposomes and Their Ability to Deliver DNA to the Nuclei of Ovarian Cancer SK-OV-3 Cells

by Mengwei Sun, Yuhao Yuan, Fake Lu and Anthony J. Di Pasqua

Materials 2021, 14(2), 416; https://doi.org/10.3390/ma14020416 - 16 Jan 2021

Cited by 4 | Viewed by 1586

Abstract

Cationic liposomes composed of 3-[N-(N’,N’-dimethylaminoethane)-carbamoyl] cholesterol (DC-chol) and dioleoylphosphatidylethanolamine (DOPE) have previously been shown to have applications in gene delivery. Our study aims to explore the effects of inclusion of polyethylene glycol (PEG) and using different molar ratios of DC-chol/DOPE on size, zeta potential, cytotoxicity and DNA delivery of DC-chol/DOPE liposomes. Our results show that PEGylation reduces the cytotoxicity of DC-chol/DOPE liposomes, and, furthermore, PEGylated liposome-DNA lipoplexes are smaller in size and more uniform in size distribution than those that are not PEGylated. Additionally, toxicity against ovarian cancer SKOV-3 cells decreases with the amount of cationic DC-chol present in the formulation; however, decreased delivery of DNA to cellular nuclei is also observed. Transfection with the PEGylated liposomes was successfully demonstrated using plasmid DNA with a known functional outcome. These results offer further insight into physicochemical properties important for cationic liposomes as vehicles for DNA delivery and demonstrate the potential of PEGylated DC-chol/DOPE liposomes as systemic delivery carriers for DNA-mediated ovarian cancer therapy. Full article

(This article belongs to the Special Issue Advanced Nanomaterials for Potential Use in Healthcare )

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9 pages, 1603 KiB

Open AccessFeature PaperArticle

Biphenyl Wrinkled Mesoporous Silica Nanoparticles for pH-Responsive Doxorubicin Drug Delivery

by Jason Lin, Chuanqi Peng, Sanjana Ravi, A. K. M. Nur Alam Siddiki, Jie Zheng and Kenneth J. Balkus, Jr.

Materials 2020, 13(8), 1998; https://doi.org/10.3390/ma13081998 - 24 Apr 2020

Cited by 21 | Viewed by 4066

Abstract

Biphenyl wrinkled mesoporous silica nanoparticles with controlled particle size and high surface area were evaluated for the storage and delivery of doxorubicin. The average particle size and surface area were ~70 nm and ~1100 m²/g. The doxorubicin loading efficiency was 38.2 ± 1.5 (w/w)% and the release was pH dependent. The breast cancer cell line, MCF-7 (Michigan Cancer Foundation-7) was used for the in vitro drug release study. The cytotoxicity of doxorubicin-loaded nanoparticles was significantly higher than free doxorubicin. Fluorescence images showed biphenyl wrinkled mesoporous silica (BPWS) uptake by the MCF-7 cells. The biphenyl bridged wrinkled silica nanoparticles appear promising for hydrophobic drug loading and delivery. Full article

(This article belongs to the Special Issue Advanced Nanomaterials for Potential Use in Healthcare )

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8 pages, 1134 KiB

Open AccessCommunication

Formula-Driven, Size-Tunable Synthesis of PMMA Nanoparticles by Varying Surfactant Concentration

by Brian L. Kamras, Nooshin Mirzanasiri, Daniel K. Korir, Sujata Mandal, Shreya L. Hariharakumar, Robby A. Petros, Sreekar B. Marpu, Denise P. Simmons and Mohammad A. Omary

Materials 2020, 13(8), 1834; https://doi.org/10.3390/ma13081834 - 13 Apr 2020

Cited by 2 | Viewed by 2209

Abstract

In this communication, we present a streamlined, reproducible synthetic method for the production of size-tunable poly(methyl methacrylate) (PMMA) nanoparticles (PMMANPs) and amine-functionalized block-copolymer PMMANPs (H₂N-PMMANPs) by varying subcritical concentrations (i.e., below the concentration required to form micelles at 1 atm and 20 °C) of sodium dodecyl sulfate (SDS). We plotted the Z-average size data against SDS concentration, which revealed a second-order exponential decay function, expressed as

A_{1} e^{(- \frac{x}{t_{1}})} + A_{2} e^{(- \frac{x}{t_{2}})} + y_{0}

. The surfactant concentration (wt./wt.%) has been selected as independent variable x. This function is valid at least for the size range of 20 nm to 97 nm (PMMANPs) and 20 nm to 133 nm (H₂N-PMMANPs). Full article

(This article belongs to the Special Issue Advanced Nanomaterials for Potential Use in Healthcare )

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